Results 51 to 60 of about 1,543 (178)
Targeting cellular senescence to combat cancer and ageing
Molecular Oncology, 2022 Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell growth arrest and by a secretome of diverse pro‐inflammatory factors, chemokines and growth ...
Chen Wang, Xue Hao, Rugang Zhang
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Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending. Despite its severe socioeconomic impact, KOA remains, to date, an incurable disease.
Andrea Bernetti +6 more
openaire +3 more sources
Senolytics: A Translational Bridge Between Cellular Senescence and Organismal Aging
Frontiers in Cell and Developmental Biology, 2020 Aging is defined as a progressive decrease in physiological function accompanied by a steady increase in mortality. The antagonistic pleiotropy theory proposes that aging is largely due to the natural selection of genes and pathways that increase fitness
Harikrishnan Thoppil +3 more
doaj +1 more source
Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis
International Journal of Molecular Sciences, 2022 Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA treatment is currently not available. Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in the etiology of OA.
Pei-Wei Weng +7 more
openaire +2 more sources
Cellular senescence in asthma: from pathogenesis to therapeutic challenges
EBioMedicine, 2023 Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms ...
Rongjun Wan +5 more
doaj +1 more source
Nicotinamide Mononucleotide Decreases Secretion of Proinflammatory Cytokines via the NAD <b><sup>+</sup></b> /SIRT1/p65 Axis. [PDF]
ACS OmegaSenescence-associated secretory phenotype (SASP) is a typical trait of senescent cells that contributes to aging and chronic diseases. Consequently, SASP is considered a potential antiaging target.
Zhang D +5 more
europepmc +2 more sources
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission
Biomedicine & Pharmacotherapy, 2023 With an aging population and the numerous health impacts associated with old age, the identification of anti-aging drugs has become an important new research direction. Although mitochondria have been recognized to affect aging, anti-aging drugs specifically targeting the mitochondria are less well characterized. In this study, diphenyleneiodonium (DPI)
Keng-Mao Liao +6 more
openaire +2 more sources
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
doaj +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
MetabolitesChronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
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