Results 61 to 70 of about 1,347 (176)
Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis
International Journal of Molecular Sciences, 2022 Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA treatment is currently not available. Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in the etiology of OA.
Pei-Wei Weng +7 more
openaire +2 more sources
, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127) +7 more
core +1 more source
, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127) +7 more
core +1 more source
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin [PDF]
Science Advances, 2020 A microRNA-activated pathway in maternal diabetes–induced neuroepithelial cell senescence leads to neural tube defects.
Cheng Xu +6 more
openaire +3 more sources
Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending. Despite its severe socioeconomic impact, KOA remains, to date, an incurable disease.
Andrea Bernetti +6 more
openaire +3 more sources
პრეპარატების შედარებითი ანალიზი, რომლებიც აუმჯობესებენ სიცოცხლის ხარისხს და სიცოცხლის ხანგრძლივობას.
, 2023 Several classes of drugs have been introduced to cellular senescence. Senomorphics that target senescence-associated secretory phenotype and senolytics, which clear senescent cells, have been shown to attenuate ageing impacts. This article introduces the
Tkemaladze, Jaba, Kipshidze, Mariam
core +1 more source
Cellular senescence in asthma: from pathogenesis to therapeutic challenges
EBioMedicine, 2023 Summary: Asthma is a heterogeneous chronic respiratory disease that impacts nearly 10% of the population worldwide. While cellular senescence is a normal physiological process, the accumulation of senescent cells is considered a trigger that transforms ...
Rongjun Wan +5 more
doaj +1 more source
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission
Biomedicine & Pharmacotherapy, 2023 With an aging population and the numerous health impacts associated with old age, the identification of anti-aging drugs has become an important new research direction. Although mitochondria have been recognized to affect aging, anti-aging drugs specifically targeting the mitochondria are less well characterized. In this study, diphenyleneiodonium (DPI)
Keng-Mao Liao +6 more
openaire +2 more sources
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
doaj +1 more source
Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, EarlyView.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source