Results 81 to 90 of about 1,171 (158)
Senescence and the Aging Immune System as Major Drivers of Chronic Kidney Disease
Frontiers in Cell and Developmental Biology, 2020 Chronic kidney disease (CKD) presents an ever-growing disease burden for the world’s aging population. It is characterized by numerous changes to the kidney, including a decrease in renal mass, renal fibrosis, and a diminished glomerular filtration rate.
Johannes Schroth +2 more
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Cellular senescence: a key therapeutic target in aging and diseases
The Journal of Clinical Investigation, 2022 Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives ...
Lei Zhang +5 more
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Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect
International Journal of Molecular SciencesCellular senescence is closely connected with cancer progression, recurrence, and metastasis. Senotherapy aims to soothe the harmful effects of senescent cells either by inducing their apoptosis (senolytic) or by suppressing the senescence-associated secretory phenotype (SASP) (senomorphic).
Agata Henschke +5 more
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Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy
Aging CellABSTRACT Senescent cells are known to contribute to aging and age‐related diseases. One key way they influence aging is by secreting senescence‐associated secretory phenotype (SASP) factors along with several damage‐associated molecular pattern (DAMP) molecules.
Anna Barkovskaya +7 more
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Lifestyle interventions to delay senescence
Biomedical JournalSenescence is a condition of cell cycle arrest that increases inflammation and contributes to the development of chronic diseases in the aging human body.
Jan Martel +2 more
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Cellular senescence in Alzheimer’s disease: from physiology to pathology
Translational NeurodegenerationAlzheimer’s disease (AD) is one of the most common neurodegenerative disorders, characterized by the accumulation of Aβ and abnormal tau hyperphosphorylation. Despite substantial efforts in development of drugs targeting Aβ and tau pathologies, effective
Jing Zhu, Chongyun Wu, Luodan Yang
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Senescence associated osteoarthritis: Emerging therapeutics and future directions
Clinical Immunology CommunicationsOsteoarthritis is a degenerative condition that primarily affects the joints. This condition is often marked by the slow degradation of cartilage as well as changes in the subchondral bone. One of the key markers of osteoarthritis is chronic inflammation.
Sheen Razdan, Anush Tomar, Sweta Bawari
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CellsOxidative stress is a prominent causal factor in the premature senescence of microvascular endothelial cells and the ensuing blood–brain barrier (BBB) dysfunction.
Jingyuan Ya, Ulvi Bayraktutan
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Aging CellABSTRACTExtracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned as senomorphics to suppress markers of senescence and the inflammatory senescence‐associated secretory ...
Tianpeng Zhang +11 more
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Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines
AbstractCellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with natural aging, functionally contributing to age-related organ dysfunction and
Hongwei Zhang +7 more
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