Results 101 to 110 of about 1,543 (178)

Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence

Cells
Oxidative stress is a prominent causal factor in the premature senescence of microvascular endothelial cells and the ensuing blood–brain barrier (BBB) dysfunction.
Jingyuan Ya, Ulvi Bayraktutan
doaj   +1 more source

Cellular senescence in lung cancer immune microenvironment and senotherapeutic opportunities

iScience
Summary: Cellular senescence (CS) shapes lung cancer biology by enforcing durable growth arrest while remodeling the tumor immune microenvironment (TIME) through the senescence-associated secretory phenotype (SASP). In non-small cell lung cancer (NSCLC),
Zhaolin Xu, Fangfang Liu, Shanshan Huang, Qian Chu   +3 more
doaj   +1 more source

The Senescence-Associated Secretory Phenotype: Induction, Regulation, Function and Therapeutic Interventions to Counteract the Negative Effects

Aging is characterized by a status of chronic low-grade systemic inflammation called “inflammaging”, that represents a leading cause of diseases typical of advanced age.
Frasca, Daniela
core   +1 more source

CELLULAR SENESCENCE: MOLECULAR MECHANISMS AND SENOLYTIC AND SENOMORPHIC STRATEGIES

Cellular senescence is an irreversible cell cycle arrest associated with chronic inflammation and age-related diseases. Senescent cells develop a senescence-associated secretory phenotype (SASP), largely regulated by NF-κB signaling, which promotes ...
Nargiza Hamzayeva, Gulnoza Jakhangirova, Anvar Normatov, Zilola Rabimova, Rakhmonova Dildor, Madina Khamidova, Mohira Khamidova, Dilafruz Zaynutdinova   +7 more
core   +1 more source

Activation of senescence in critically ill patients: mechanisms, consequences and therapeutic opportunities

Annals of Intensive Care
Whereas aging is a whole-organism process, senescence is a cell mechanism that can be triggered by several stimuli. There is increasing evidence that critical conditions activate cell senescence programs irrespective of patient’s age.
Paula Martín-Vicente, Cecilia López-Martínez, Beatriz Rioseras, Guillermo M. Albaiceta   +3 more
doaj   +1 more source

Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines

Abstract Cellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP).
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Sanhong Liu, James L. kirkland, Weidong Zhang, Yu Sun   +7 more
openaire   +1 more source

Enhancing immunity during ageing by targeting interactions within the tissue environment

Immunity declines with age. This results in a higher risk of age-related diseases, diminished ability to respond to new infections and reduced response to vaccines.
Bracken, Olivia V, Akbar, Arne N, De Maeyer, Roel PH   +2 more
core   +1 more source

Tissue turnover and rejuvenation through mechanics. [PDF]

Front Cell Dev Biol
Uchida M, Toyama Y.
europepmc   +1 more source

Terpenoids as Emerging Senotherapeutics: Mechanistic Insights and Therapeutic Potential

Cellular senescence, characterized by stable cell cycle arrest, drives organismal aging and functional decline. Senescent cells (SnCs) increase in multiple tissues with age and contribute to pathology by resisting apoptosis, impairing regeneration, and ...
Sung-Joon Lee, Jung Yoon Park, Sungwoo Yi   +2 more
core   +1 more source

Cleaning, Chasing and Calming: Promising Paradigms of Senotherapy in Aging-Related Diseases. [PDF]

Int J Biol Sci
Ran S, Zhou S, Ma H, Zhang F, Yang Y, Abulajiang M, Yang X, Li S, Zhang Q.   +8 more
europepmc   +1 more source