Results 121 to 130 of about 1,347 (176)

Synergistic targeting of senolytic and senomorphic action with dual-engineered biomimetic macrophage nanovesicles for mitigating osteoarthritis

Bioactive Materials
Osteoarthritis (OA), a leading cause of chronic disability worldwide, is increasingly recognized to be driven by the accumulation of senescent chondrocytes (sCDs) and their deleterious pro-inflammatory senescence-associated secretory phenotype (SASP).
Wenan Peng, Ziming Wang, Zenan Zhuang, Simin Zeng, Yu Xia, Qiwen Chen, Xuan Bai, Ying Tang, Cui Huang, Xianzheng Zhang   +9 more
openaire   +3 more sources

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent

aging and disease
Assessing impact on the hallmarks of aging has emerged as a novel method for prioritizing dual-purpose longevity therapeutic targets and developing drugs simultaneously targeting aging and disease. Cellular senescence, a central hallmark of aging, progressively induces cellular growth arrest and accelerates the production of a pro-inflammatory ...
Tang, Qiuqiong, Xiao, Deyong, Veviorskiy, Alexander, Xin, Ying, Lok, Sarah W.Y., Pulous, Fadi E., Zhang, Peiran, Zhu, Yunfeng, Ma, Yongming, Hu, Xiao, Gu, Shoulai, Zong, Chenting, Mukba, Sabina, Korzinkin, Mikhail, Pun, Frank W., Zhang, Man, Aliper, Alex, Wu, Lijuan, Ren, Feng, Zhang, Li, Zhavoronkov, Alex   +20 more
openaire   +2 more sources

Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines

Abstract Cellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP).
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Sanhong Liu, James L. kirkland, Weidong Zhang, Yu Sun   +7 more
openaire   +1 more source

Enhancing adipose tissue functionality in obesity: senotherapeutics, autophagy and cellular senescence as a target

Obesity, a global health crisis, disrupts multiple systemic processes, contributing to a cascade of metabolic dysfunctions by promoting the pathological expansion of visceral adipose tissue (VAT).
Arias, Consuelo, Kerr, Bredford, Javiera Álvarez-Indo, Burgos, Patricia V., Bredford Kerr, Mariana Cifuentes, Morselli, Eugenia, Consuelo Arias, Cifuentes, Mariana, Eugenia Morselli, Álvarez-Indo, Javiera, Patricia V. Burgos   +11 more
core   +1 more source

Chronic Kidney Disease and Cellular Senescence. [PDF]

Int J Mol Sci
Morevati M, Tavenier J, Scheibye-Knudsen M, Houlind MB, Hedayati A, Hornum M.   +5 more
europepmc   +1 more source

Senescence-associated secretory phenotype: the "pathogenic" factor driving orthopedic degenerative diseases and its regulation. [PDF]

Front Aging
Ren J, Wang X, Zhou X, Fan X.
europepmc   +1 more source

Advances in the management of osteoporosis

Osteoporosis is a chronic disease mainly prevalent in older people. A hip fracture, its most devastating complication, is associated with a one in five chance of mortality in the first year.
Sfeir, Jad G, Hoong, Caroline Wei Shan, Saul, Dominik, Khosla, Sundeep   +3 more
core   +1 more source

The geroscience hypothesis: Economic paradigms and pharmacological strategies for healthspan extension. [PDF]

J Taibah Univ Med Sci
Alotaibi AF, Aljasser AI, Alkattan AN, Alkhoraisi A, Assiri AM.   +4 more
europepmc   +1 more source

Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy. [PDF]

Curr Issues Mol Biol
Kusmanto SJ.
europepmc   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease. [PDF]

Adv Sci (Weinh)
Misawa T, A A, Hickson LJ, Wolfram J.
europepmc   +1 more source