Results 141 to 150 of about 1,171 (158)

HYDROCHLOROTHIAZIDE AS A NEW SENOMORPHIC DRUG CANDIDATE

Amaç: Konvansiyonel kanser tedavisinde kullanılan kemoterapötiklerin hem kanser hem de kanser olmayan hücrelerde hücresel senesensi indüklediği bilinmektedir. Senesent hücrelerin önemli özellikleri, hücre morfolojilerinde belirgin değişikliklerin olması ve bu hücrelerden senesens ilişkili sekretuvar fenotip (SASP) olarak adlandırılan çeşitli sitokin ...
Şimay Demir, Yaprak Dilber, Akgül, Senem   +1 more
openaire   +1 more source

Combating Atherosclerosis with Chirality/Phase Dual‐Engineered Nanozyme Featuring Microenvironment‐Programmed Senolytic and Senomorphic Actions

Advanced Materials
AbstractSenescence plays a critical role in the development and progression of various diseases. This study introduces an amorphous, high‐entropy alloy (HEA)‐based nanozyme designed to combat senescence. By adjusting the nanozyme's composition and surface properties, this work analyzes its catalytic performance under both normal and aging conditions ...
Chengjin Ding, Jiao Min, Yongkang Tan, Liuting Zheng, Ruxuan Ma, Ruyi Zhao, Huiyue Zhao, Qingqing Ding, Hongshan Chen, Da Huo   +9 more
openaire   +2 more sources

Dapagliflozin Exerts Senomorphic Effects on Adriamycin-Induced Podocyte Injury via Modulation of Complosome

Journal of the American Society of Nephrology, 2023
Giuseppe Castellano, Min Li, Deborah Mattinzoli, Silvia Armelloni, Masami Ikehata, Carlo Alfieri   +5 more
openaire   +1 more source

Shotgun Study Reveals Senomorphic Targets Based on SASP Mediated by SEV

Cells have the capacity to modulate the microenvironment through the secretion of molecules (cytokines, chemokines, matrix proteins…) and vesicles, which vary according to the pathology involved, such as cancer or the natural process such as senescence.
Lucio-Gallego, Sergio, Mato-Basalo, Rocío, Alarcón-Veleiro, Carmen, Berjawi, Lama, López-Calvo, Ismael, Carrera, Mónica, Gutiérrez, Lola, Gil, Concha, Mateos, Jesús, Arufe, María C., Fafián-Labora, Juan   +10 more
openaire   +1 more source

RISING STARS: Targeting premature cellular senescence using senomorphic or senolytic agents to impact diabetes

Journal of Molecular Endocrinology
Abstract Type 2 diabetes mellitus (DM) is closely associated with cellular senescence (SnC), a state of irreversible cell cycle arrest marked by functional decline. Preventing cellular senescence in already diagnosed DM patients is crucial for limiting disease progression and the onset of co-morbidities.
Mari van de Vyver, Saiuree Govender, Kelly Petersen-Ross, Kayla Howard   +3 more
openaire   +1 more source

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

FEBS Journal, 2023
Lei Zhang, Paul D Robbins, Laura J Niedernhofer   +2 more
exaly  

Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics

Tissue Barriers, 2023
Jingyuan Ya, Rais Reskiawan Abdul Kadir, Ulvi Bayraktutan   +2 more
exaly  

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Annual Review of Pharmacology and Toxicology, 2021
Paul D Robbins, Diana Jurk, Sundeep Khosla   +2 more
exaly  

Activatable and Self-Monitoring Hydrogen Sulfide-Based Molecular Senomorphics for Visualized Regulation of Cellular Senescence

CCS Chemistry, 2023
exaly  

Targeting Molecular Mechanism of Vascular Smooth Muscle Senescence Induced by Angiotensin II, A Potential Therapy via Senolytics and Senomorphics

International Journal of Molecular Sciences, 2020
Keisuke Okuno, Stephanie Cicalese, Tatsuo Kawai   +2 more
exaly