Results 161 to 170 of about 1,347 (176)
Emerging roles of senolytics/senomorphics in HIV-related co-morbidities
Biochemical PharmacologyHuman immunodeficiency virus (HIV) is known to cause cellular senescence and inflammation among infected individuals. While the traditional antiretroviral therapies (ART) have allowed the once fatal infection to be managed effectively, the quality of life of HIV patients on prolonged ART use is still inferior. Most of these individuals suffer from life-
Gagandeep Kaur +2 more
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Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction
2023The accumulation of senescent cells in the aging individual is associated with an increase in the occurrence of age-associated pathologies that contribute to poor health, frailty, and mortality. The number and type of senescent cells is viewed as a contributor to the body's senescence burden.
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Senomorphic properties of miR-181b in aged human aortic smooth muscle cells
Physiology, 2023Introduction: Age associated large artery stiffness (LAS) is an independent predictor of adverse cardiovascular health outcomes in humans and has also been shown to be associated with the development of heart failure, kidney disease, and even dementia.
Denisse Moreno +5 more
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TargetsTaken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Jianmin Zou, Jiayue Guo, An Peng
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Senomorphic, senolytic, and rejuvenation therapies
2022Xiang Yang Zhu, Lilach O. Lerman
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HYDROCHLOROTHIAZIDE AS A NEW SENOMORPHIC DRUG CANDIDATE
Amaç: Konvansiyonel kanser tedavisinde kullanılan kemoterapötiklerin hem kanser hem de kanser olmayan hücrelerde hücresel senesensi indüklediği bilinmektedir. Senesent hücrelerin önemli özellikleri, hücre morfolojilerinde belirgin değişikliklerin olması ve bu hücrelerden senesens ilişkili sekretuvar fenotip (SASP) olarak adlandırılan çeşitli sitokin ...Şimay Demir, Yaprak Dilber +1 more
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Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
FEBS Journal, 2023Laura J Niedernhofer, Paul D Robbins
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Targeting Senescence-Inducing Vesicles: The Endomembrane System as a Senomorphic Avenue
Secreted molecules as cytokines, chemokines, grow factors and the release of small extracellular vesicles (sEV) modulate the cellular microenvironment. Senescent cells main characteristics are the inhibition of the cell cycle, an increased β-galactosidase activity and a specific secretome of the previous compounds known as Senescence Associated ...Lucio-Gallego, Sergio +7 more
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