Results 161 to 170 of about 1,543 (178)

HYDROCHLOROTHIAZIDE AS A NEW SENOMORPHIC DRUG CANDIDATE

Amaç: Konvansiyonel kanser tedavisinde kullanılan kemoterapötiklerin hem kanser hem de kanser olmayan hücrelerde hücresel senesensi indüklediği bilinmektedir. Senesent hücrelerin önemli özellikleri, hücre morfolojilerinde belirgin değişikliklerin olması ve bu hücrelerden senesens ilişkili sekretuvar fenotip (SASP) olarak adlandırılan çeşitli sitokin ...
Şimay Demir, Yaprak Dilber, Akgül, Senem   +1 more
openaire   +1 more source

Pharmacological Modulation of Immunosenescence and Inflammaging: Senolytics, Senomorphics, and Emerging Therapies

Immunological Investigations
Bhavya R, Rajendra Sandur V
exaly   +2 more sources

Senomorphic, senolytic, and rejuvenation therapies

2022
Xiang Yang Zhu, Lilach O. Lerman
openaire   +1 more source

Targeting Cellular Senescence: Therapeutic Advances in Senolytic and Senomorphic Interventions for Age-Related Pathologies

Current Topics in Medicinal Chemistry
Aging is an inevitable biological process characterized by a progressive decline in physiological functions, increased vulnerability to disease, and ultimately death. While aging is influenced by genetic, environmental, and lifestyle factors, accumulating evidence indicates that cellular senescence is a central
Seshathri Pandurangan, Dhunmati Kuppuram, Ramalakshmi Arunkumar, Nalini Nagarajan   +3 more
openaire   +2 more sources

Activatable and Self-Monitoring Hydrogen Sulfide-Based Molecular Senomorphics for Visualized Regulation of Cellular Senescence

CCS Chemistry, 2023
Yanlan Liu, Weihong Tan, Jili Li
exaly  

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics

FEBS Journal, 2023
Laura Niedernhofer, Paul Robbins
exaly  

Targeting Senescence-Inducing Vesicles: The Endomembrane System as a Senomorphic Avenue

Secreted molecules as cytokines, chemokines, grow factors and the release of small extracellular vesicles (sEV) modulate the cellular microenvironment. Senescent cells main characteristics are the inhibition of the cell cycle, an increased β-galactosidase activity and a specific secretome of the previous compounds known as Senescence Associated ...
Lucio-Gallego, Sergio, Mato-Basalo, Rocío, Carrera, Mónica, Gutiérrez, Lola, Gil, Concha, Mateos, Jesús, Arufe, María C., Fafián-Labora, Juan   +7 more
openaire   +1 more source

Senolytic Drugs: Reducing Senescent Cell Viability to Extend Health Span

Annual Review of Pharmacology and Toxicology, 2021
João Passos, Laura Niedernhofer, Nathan Lebrasseur   +2 more
exaly  

Cellular Senescence in Lung Fibrosis

International Journal of Molecular Sciences, 2021
Fernanda Hernández-González, Jacobo Sellarés, Manuel Serrano   +2 more
exaly  

Targeting Molecular Mechanism of Vascular Smooth Muscle Senescence Induced by Angiotensin II, A Potential Therapy via Senolytics and Senomorphics

International Journal of Molecular Sciences, 2020
Satoru Eguchi, Tatsuo Kawai, Stephanie Cicalese   +2 more
exaly