Results 151 to 160 of about 1,347 (176)
Senolytic Treatment Improves Responsiveness to Mechanical Loading in the Skeleton of Aged Mice. [PDF]
Int J Mol SciCunningham CJ +4 more
europepmc +1 more source
The Relevance of Chronological and Biological Aging in the Progression of Multiple Sclerosis. [PDF]
Healthcare (Basel)Mulero P +2 more
europepmc +1 more source
Dual Roles and Therapeutic Prospects of Proximal Tubular Epithelial Cell Senescence in Acute Kidney Injury. [PDF]
BiomoleculesQiao Y +8 more
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Emerging use of senolytics and senomorphics against aging and chronic diseases
Medicinal Research Reviews, 2020 AbstractSenescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age‐related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary ...
Jan Martel +2 more
exaly +6 more sources
Tissue Barriers, 2023 Accumulation of senescent cells in cerebrovasculature is thought to play an important role in age-related disruption of blood–brain barrier (BBB). Using an in vitro model of human BBB, composed of brain microvascular endothelial cells (BMECs), astrocytes
Jingyuan Ya +2 more
exaly +3 more sources
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Free Radical Biology and Medicine, 2021
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Niki Chondrogianni
exaly +3 more sources
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Niki Chondrogianni
exaly +3 more sources
Biogerontology, 2022
Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Humberto Gutierrez +2 more
exaly +3 more sources
Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Humberto Gutierrez +2 more
exaly +3 more sources