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Emerging use of senolytics and senomorphics against aging and chronic diseases
Medicinal Research Reviews, 2020 © 2020 Wiley Periodicals LLC Senescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer.
Cheng-Yeu Wu +2 more
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International Journal of Molecular SciencesCellular senescence, a state of stable cell cycle arrest accompanied by a complex senescence-associated secretory phenotype (SASP), is a fundamental biological process implicated as a key driver of lung aging and lung age-related diseases (LARDs).
Gagandeep Kaur +2 more
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TargetsTaken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs.
Jiayue Guo +2 more
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Delay of endothelial cell senescence protects cerebral barrier against age-related dysfunction: role of senolytics and senomorphics [PDF]
Tissue Barriers, 2023 Accumulation of senescent cells in cerebrovasculature is thought to play an important role in age-related disruption of blood–brain barrier (BBB). Using an in vitro model of human BBB, composed of brain microvascular endothelial cells (BMECs), astrocytes
Ulvi Bayraktutan +2 more
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Biogerontology, 2022
Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Jaime Pérez-Villanueva +2 more
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Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Jaime Pérez-Villanueva +2 more
exaly +3 more sources
Free Radical Biology and Medicine, 2021
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Niki Chondrogianni
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Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Niki Chondrogianni
exaly +3 more sources
Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction
2023The accumulation of senescent cells in the aging individual is associated with an increase in the occurrence of age-associated pathologies that contribute to poor health, frailty, and mortality. The number and type of senescent cells is viewed as a contributor to the body's senescence burden.
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Senomorphic properties of miR-181b in aged human aortic smooth muscle cells
Physiology, 2023Introduction: Age associated large artery stiffness (LAS) is an independent predictor of adverse cardiovascular health outcomes in humans and has also been shown to be associated with the development of heart failure, kidney disease, and even dementia.
Denisse Moreno +5 more
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