Senotherapeutics for Brain Aging Management [PDF]
Neurology InternationalBrain aging is a progressive process marked by cellular dysfunction, chronic inflammation, and increased susceptibility to neurodegenerative diseases.
Timur Saliev, Prim B. Singh
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Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration [PDF]
BiomoleculesCellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Julia Delenko +12 more
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Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer [PDF]
Current OncologySince cancer is often linked to the aging process, the importance of cellular senescence in cancer has come under the spotlight. While senescence in cancer cells can serve as a natural barrier against cancer due to its proliferation arrest, its secretory
Satoru Meguro +15 more
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Cellular senescence: Molecular signatures and cellular remodeling. [PDF]
FEBS Open BioCellular senescence, a state of stable cell‐cycle arrest accompanied by profound metabolic and secretory changes, has emerged as a central hallmark of aging and a key contributor to age‐associated diseases. Despite the great progress in understanding the characteristics, the underlying molecular mechanisms, and the role of senescent cells in several ...
Kletsas D.
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Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly
Frontiers in Cellular and Infection Microbiology, 2023 In the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other.
Mingfu Tian +2 more
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Targeting Hyperoxia-Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants. [PDF]
Aging CellSupplemental oxygen is critical for premature infants. While initially beneficial, even moderate hyperoxia (< 60% O2) induces detrimental cellular senescence in developing airways with long‐lasting consequences. Senotherapeutics such as Fucoidan, Dasatinib (D) + Quercetin (D + Q), and mitochondrial‐targeted antioxidant MitoQ may be beneficial in ...
Koloko Ngassie ML +8 more
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Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy [PDF]
Current Issues in Molecular BiologyCellular senescence is an irreversible cell cycle arrest, triggered by stressors like telomere shortening, DNA damage, and oncogenic signaling. These cells, often referred to as ‘zombie cells’ because they cease dividing yet resist apoptosis, drive the ...
Steven Januar Kusmanto
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Integrative Approaches to Treating Cellular Senescence in Kidney Disease. [PDF]
Adv Sci (Weinh)ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Misawa T, A A, Hickson LJ, Wolfram J.
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Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool [PDF]
Transplant InternationalOur aging population is reshaping transplantation medicine. As demand for liver transplantation continues to rise, an aging donor pool presents unique challenges, with marginal organs becoming increasingly prevalent and representing a critical yet ...
Madita L. Buch +5 more
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Network Pharmacology and Machine Learning Identify Flavonoids as Potential Senotherapeutics [PDF]
PharmaceuticalsBackground/Objectives: Cellular senescence is characterised by irreversible cell cycle arrest and the secretion of a proinflammatory phenotype. In recent years, senescent cell accumulation and senescence-associated secretory phenotype (SASP) secretion ...
Jose Alberto Santiago-de-la-Cruz +3 more
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