Senotherapeutics for Brain Aging Management [PDF]
Neurology InternationalBrain aging is a progressive process marked by cellular dysfunction, chronic inflammation, and increased susceptibility to neurodegenerative diseases.
Timur Saliev, Prim B. Singh
exaly +7 more sources
Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Corina Bubueanu +2 more
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Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration [PDF]
BiomoleculesCellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Julia Delenko +12 more
doaj +11 more sources
Targeting cellular senescence through nutritional senotherapeutics in brain aging and neurodegenerative diseases [PDF]
Frontiers in NutritionCellular senescence has emerged as a key contributor to brain aging and neurodegenerative diseases, which are increasing in prevalence as life expectancy rises.
Verónica Salas-Venegas +5 more
doaj +3 more sources
Targeting Senescence in Oncology: An Emerging Therapeutic Avenue for Cancer [PDF]
Current OncologySince cancer is often linked to the aging process, the importance of cellular senescence in cancer has come under the spotlight. While senescence in cancer cells can serve as a natural barrier against cancer due to its proliferation arrest, its secretory
Satoru Meguro +15 more
doaj +3 more sources
Senotherapeutics: An Emerging Approach to the Treatment of Viral Infectious Diseases in the Elderly
Frontiers in Cellular and Infection Microbiology, 2023 In the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other.
Tian Mingfu
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Senescence-Associated Transcriptome Reversal Prioritizes Repurposing Candidates for Diabetic Kidney Disease: A Computational Study [PDF]
BiomedicinesBackground/Objectives: Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease, and cellular senescence is a tractable therapeutic target; yet prioritizing credible repurposing candidates is difficult because bulk-tissue senescence ...
Duygu Aygüneş-Jafari +1 more
doaj +2 more sources
Simultaneous induction of differentiation and senescence in cardiac fibroblasts by TGF-β1: effects of senotherapeutics drugs [PDF]
Frontiers in PharmacologyIntroductionAging is a major risk factor for cardiovascular diseases (CVD), partly due to the accumulation of senescent cells. Senescence is characterized by irreversible cell cycle arrest and the acquisition of a senescence associated secretory ...
Claudio Espinoza-Perez +12 more
doaj +2 more sources
Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool [PDF]
Transplant InternationalOur aging population is reshaping transplantation medicine. As demand for liver transplantation continues to rise, an aging donor pool presents unique challenges, with marginal organs becoming increasingly prevalent and representing a critical yet ...
Madita L. Buch +5 more
doaj +2 more sources
Senescence Modulation: An Applied Science Review of Strategies in Anti-Aging, Regenerative Aesthetics, and Oncology Therapy [PDF]
Current Issues in Molecular BiologyCellular senescence is an irreversible cell cycle arrest, triggered by stressors like telomere shortening, DNA damage, and oncogenic signaling. These cells, often referred to as ‘zombie cells’ because they cease dividing yet resist apoptosis, drive the ...
Steven Januar Kusmanto
doaj +2 more sources