Results 1 to 10 of about 416 (129)
Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Jose-Ramón Blanco, Amancio Carnero
exaly +8 more sources
Senotherapeutics for Brain Aging Management
Neurology InternationalBrain aging is a progressive process marked by cellular dysfunction, chronic inflammation, and increased susceptibility to neurodegenerative diseases.
Timur Saliev, Prim Singh
exaly +6 more sources
The costs and benefits of senotherapeutics for human health [PDF]
The Lancet. Healthy Longevity, 2022 Summary: Cellular senescence is a major contributor to age-related diseases in humans; however, it also has a beneficial role in physiological and pathological processes, including wound healing, host immunity, and tumour suppression. Reducing the burden
Marco Raffaele, PhD +1 more
doaj +6 more sources
Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics [PDF]
Antioxidants, 2023 Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however,
Vicente Micol +2 more
exaly +4 more sources
Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Ramona-Daniela Pavaloiu +4 more
doaj +2 more sources
Aging and Senotherapeutics [PDF]
Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, 2019 One of the key mechanisms of the aging process of an organism and of the dysfunctionality and chronic diseases related with aging is the so-called cell senescence. It implies irreversible cell cycle arrest that occurs in response to different forms of cellular stress.
Čepelak, Ivana, Dodig, Slavica
openaire +4 more sources
Senotherapeutics: An emerging approach to the treatment of viral infectious diseases in the elderly
Frontiers in Cellular and Infection Microbiology, 2023 In the context of the global COVID-19 pandemic, the phenomenon that the elderly have higher morbidity and mortality is of great concern. Existing evidence suggests that senescence and viral infection interact with each other.
Chengliang Zhu +2 more
exaly +3 more sources
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Cells, 2023 Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many ...
Masayoshi Suda +7 more
doaj +2 more sources
Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced ...
Carla Luís +13 more
doaj +2 more sources
Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration [PDF]
BiomoleculesCellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Julia Delenko +12 more
doaj +9 more sources