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Cellular Senescence in Skeletal Muscle Aging [PDF]
Endocrinology and MetabolismCellular senescence is increasingly recognized as a pivotal mechanism driving skeletal muscle aging and the development of sarcopenia, a condition characterized by the progressive loss of muscle mass, strength, and function.
Yang Li, Huating Wang
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The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action [PDF]
PharmaceuticalsBackground: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova +4 more
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IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy
Frontiers in Cell and Developmental Biology, 2023 Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secretion
Donatella Romaniello +14 more
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Regulation of Cellular Senescence in Type 2 Diabetes Mellitus: From Mechanisms to Clinical Applications [PDF]
Diabetes & Metabolism Journal, 2023 Cellular senescence is accelerated by hyperglycemia through multiple pathways. Therefore, senescence is an important cellular mechanism to consider in the pathophysiology of type 2 diabetes mellitus (T2DM) and an additional therapeutic target. The use of
Kanako Iwasaki +2 more
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On the past, present and future of senotherapeutics [PDF]
npj AgingMarco Quarta, Marco Demaria
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Idiopathic pulmonary fibrosis - novel approach on future treatment
Journal of Education, Health and Sport, 2023 Introduction Idiopathic pulmonary fibrosis (IPF) is a fatal pulmonary disease that leads to progressive fibrosis and extremely poor resaults.. Since the etiology is unknown, there are highly limited options of the IPF treatment.
Katarzyna Pacek +7 more
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Skin aging from mechanisms to interventions: focusing on dermal aging
Frontiers in Physiology, 2023 Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms that lead to various structural and physiological changes in the skin.
Sun Hye Shin +3 more
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Aging and oral squamous cell carcinoma development: the role of cellular senescence
Frontiers in Oral Health, 2023 The gradual accumulation and inadequate renewal of senescent cells over time drive organismal aging. Senescent cells undergo altered gene expression and release inflammatory mediators collectively termed the senescence-associated secretory phenotype ...
Sven Eric Niklander +3 more
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Biomolecules, 2023 Background: Low back pain is a global health problem directly related to intervertebral disc (IVD) degeneration. Senolytic drugs (RG-7112 and o-Vanillin) target and remove senescent cells from IVDs in vitro, improving tissue homeostasis.
Matthew Mannarino +8 more
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Cellular senescence: a key therapeutic target in aging and diseases
The Journal of Clinical Investigation, 2022 Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives ...
Lei Zhang +5 more
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