Results 31 to 40 of about 1,649 (193)
Senescent Cells: A Therapeutic Target in Cardiovascular Diseases
Cells, 2023 Senescent cell accumulation has been observed in age-associated diseases including cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence-associated secretory phenotype (SASP) factors that may cause or worsen many ...
Masayoshi Suda +7 more
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IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy
Frontiers in Cell and Developmental Biology, 2023 Historically, senescence has been considered a safe program in response to multiple stresses in which cells undergo irreversible growth arrest. This process is characterized by morphological and metabolic changes, heterochromatin formation, and secretion
Donatella Romaniello +14 more
doaj +1 more source
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]
The FEBS Journal, 2022 The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang +4 more
openaire +2 more sources
Skin aging from mechanisms to interventions: focusing on dermal aging
Frontiers in Physiology, 2023 Skin aging is a multifaceted process that involves intrinsic and extrinsic mechanisms that lead to various structural and physiological changes in the skin.
Sun Hye Shin +3 more
doaj +1 more source
Senotherapeutics for metabolic disease and diabetic complications. [PDF]
J Intern MedAbstract Metabolic diseases, including obesity, Type 2 diabetes (T2D), and metabolic syndrome, are increasingly prevalent worldwide, driven by sedentary lifestyles, aging populations, and complex genetic and environmental factors. Traditionally understood as disorders of glucose and lipid metabolism, a growing body of evidence now ...
Palmer AK +7 more
europepmc +3 more sources
Biomolecules, 2023 Background: Low back pain is a global health problem directly related to intervertebral disc (IVD) degeneration. Senolytic drugs (RG-7112 and o-Vanillin) target and remove senescent cells from IVDs in vitro, improving tissue homeostasis.
Matthew Mannarino +8 more
doaj +1 more source
Repurposing digoxin for geroprotection in patients with frailty and multimorbidity [PDF]
, 2023 The geroscience hypothesis proposes biological hallmarks of ageing are modifiable. Increasing evidence supports targeting these hallmarks with therapeutics could prevent and ameliorate age-related conditions - collectively termed "geroprotector drugs ...
Bunting, Karina V +4 more
core +1 more source
Cellular senescence: a key therapeutic target in aging and diseases
The Journal of Clinical Investigation, 2022 Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in response to cellular damage and stress. Senescent cells (SnCs) can develop a characteristic pathogenic senescence-associated secretory phenotype (SASP) that drives ...
Lei Zhang +5 more
doaj +1 more source
The Evolving Role of CD8+CD28- Immunosenescent T Cells in Cancer Immunology [PDF]
, 2019 Functional, tumor-specific CD8+ cytotoxic T lymphocytes drive the adaptive immune response to cancer. Thus, induction of their activity is the ultimate aim of all immunotherapies.
Dey, Mahua +4 more
core +1 more source