Results 51 to 60 of about 1,649 (193)
Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis
Seminars in Cell & Developmental Biology, 2020 Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease characterized by progressive scarring of the lung tissue, leading to respiratory failure. There is no cure for IPF, and current anti-fibrotic treatments modestly arrest its further progression. IPF prevalence and incidence increase with age, which is a recognized risk factor.
Wolfgang, Merkt +3 more
openaire +3 more sources
Distinct mechanisms mediating therapy-induced cellular senescence in prostate cancer [PDF]
, 2022 Background: Prostate cancer (PCa) is an age-related malignancy in men with a high incidence rate. PCa treatments face many obstacles due to cancer cell resistance and many bypassing mechanisms to escape therapy.
Atri Roozbahani, Golnaz +3 more
core +2 more sources
From genoprotection to rejuvenation
Frontiers in Bioscience-Landmark, 2020 Aging results from aberrations in signaling mechanisms and decline in biologic activities and cellular functions. Anti-aging strategies include a number of dietary, genetic, and pharmacological interventions that converge on a core network of nutrient ...
Siamak Tabibzadeh
doaj +1 more source
The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions [PDF]
, 2021 BACKGROUND: Advanced maternal age is associated with decreased oocyte quantity and quality as well as uterine and placental dysfunctions. These changes lead to infertility, pregnancy complications and birth defects in the offspring.
Borghesan, Michela +3 more
core +1 more source
Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Sachi Matsubayashi +3 more
doaj +1 more source
Implications of cellular senescence in paediatric pituitary tumours [PDF]
, 2023 The long-standing view of senescent cells as passive and dysfunctional biological remnants has recently shifted into a new paradigm where they are main players in the development of many diseases, including cancer.
Gonzalez-Meljem, Jose Mario +1 more
core
Senotherapeutic Drugs: A New Avenue for Skincare?
Plastic & Reconstructive Surgery, 2021 Summary: Skin aging is an outward manifestation of other cellular and molecular aging processes occurring elsewhere in the body. These processes are known collectively as the “hallmarks” of aging, which are a series of basic health maintenance mechanisms that fail over time. Cellular senescence is one of the most studied of the
Lee, BP, Harries, LW
openaire +4 more sources
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
Senescent macrophages in cancer: roles in tumor progression and treatment opportunities
Cancer Biology & MedicineSenescent macrophages have emerged as dynamic cells within the tumor microenvironment that significantly promote tumor progression through complex cellular and molecular functional alterations.
Tianzi Wang +4 more
doaj +1 more source
Senolytics and exercise: Dual modalities for rejuvenating muscle
The Journal of Physiology, EarlyView.Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican +4 more
wiley +1 more source