Results 51 to 60 of about 416 (129)
Cellular Senescence in Health, Disease, and Lens Aging
PharmaceuticalsBackground: Cellular senescence is a state of irreversible cell cycle arrest that serves as a critical regulator of tissue homeostasis, aging, and disease.
Ying Qin, Haoxin Liu, Hongli Wu
doaj +1 more source
Therapy-induced senescence in breast cancer: an overview
Exploration of Targeted Anti-tumor TherapyOutcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present with intrinsic drug resistance and others are initially sensitive to anti-cancer drugs but acquire resistance during the course of their ...
Suraj Narayanan Chembukavu +1 more
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Senolytic Therapy as a Preventive Strategy for Spine Degeneration and Pain
Advanced Science, Volume 13, Issue 46, 17 August 2026.Cellular senescence promotes inflammation, tissue degeneration, and chronic back pain. In sparc‐null mice, early oral administration of the senolytic agents o‐vanillin and RG‐7112 reduced senescent cell burden and pro‐inflammatory SASP signaling across intervertebral discs, endplates, vertebral bone, and spinal cord.
Saber Ghazizadeh +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 47, 24 August 2026.The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian +9 more
wiley +1 more source
Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies [PDF]
Cellular senescence is implicated in ageing and associated with a broad spectrum of agerelated diseases. Importantly, a cell can initiate the senescence program irrespective of the organism’s age.
Caruso, Calogero +11 more
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Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights
Aging Cell, Volume 25, Issue 8, August 2026.Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley +1 more source
Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy
Aging Cell, Volume 25, Issue 8, August 2026.MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco +8 more
wiley +1 more source
Inflammaging: Experimental Insights and Translational Advances
European Journal of Immunology, Volume 56, Issue 7, July 2026.Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley +1 more source
Use of senotherapeutics in the treatment of chronic pulmonary diseases
, 2022 Kod kroničnih plućnih bolesti postoje nakupine senescentnih stanica. Senoterapeutici djeluju na sam uzrok bolesti i time se sprječava progresija plućnih bolesti. Senolitici su lijekovi koji potiču apoptozu senescentnih stanica.
Stokanović, Tihana
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Osteoimmune senescence in aging-related bone diseases
Frontiers in ImmunologyAging-related bone diseases are increasingly recognized as disorders in which uncoupled bone remodeling remains central but is substantially modified by immune-skeletal interactions. This review consolidates current evidence for osteoimmune senescence, a
Huali Li, Yingli Yang, Huanle Zhu
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