Results 71 to 80 of about 416 (129)

The Regulation of Cellular Senescence in Cancer

Biomolecules
Cellular senescence is a stable state of cell cycle arrest caused by telomere shortening or various stresses. After senescence, cells cease dividing and exhibit many age-related characteristics. Unlike the halted proliferation of senescence cells, cancer
Xianhong Zhang, Yue Gao, Siyu Zhang, Yixiong Wang, Yitian Du, Shuailin Hao, Ting Ni   +6 more
doaj   +1 more source

Senescent Myoblasts Exhibit ROS‐Dependent Akt‐mTORC1 Dysregulation and Are Susceptible to Reductive Stress‐Induced Cell Death

Aging Cell, Volume 25, Issue 6, June 2026.
Senescent myoblasts exhibit dysregulated Akt/mTORC1 signalling. Antioxidants can alleviate this dysregulation, as well as other downstream senescent phenotypes. Moreover, prolonged antioxidant treatment can selectively induce cell death in senescent myoblasts, suggesting that these cells are more susceptible to reductive stress.
Vladimir Belhac, Alex Dillingham, Emilia Coward, Bradley Teal, Mark C. Turner, Stephanie D. Gagnon, Jiani Qian, Harry Wilford, Ella Warren, Natalie Moger, Bernadette Carroll, Owen G. Davies, Hannah F. Dugdale, Neil R. W. Martin   +13 more
wiley   +1 more source

Terpenoids as Emerging Senotherapeutics: Mechanistic Insights and Therapeutic Potential

Cellular senescence, characterized by stable cell cycle arrest, drives organismal aging and functional decline. Senescent cells (SnCs) increase in multiple tissues with age and contribute to pathology by resisting apoptosis, impairing regeneration, and ...
Sung-Joon Lee, Jung Yoon Park, Sungwoo Yi   +2 more
core   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Cellular senescence in cancer: molecular mechanisms and therapeutic targets

MedComm
Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes.
Ping Jin, Xirui Duan, Lei Li, Ping Zhou, Cheng‐Gang Zou, Ke Xie   +5 more
doaj   +1 more source

SGLT2 inhibitors as a novel senotherapeutic approach

npj Aging
Abstract Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues and organs with aging contribute to many chronic diseases, mainly through the secretion of a pro-inflammatory senescence-associated secretory phenotype (SASP).
Zeynep Elif Yesilyurt-Dirican, Ce Qi, Yi-Chian Wang, Annika Simm, Laura Deelen, Alia Hafiz Abbas Gasim, Fiona Lewis-McDougall, Georgina M. Ellison-Hughes   +7 more
openaire   +2 more sources

Cellular Senescence in Skeletal Muscle Aging [PDF]

Endocrinology and Metabolism
Cellular senescence is increasingly recognized as a pivotal mechanism driving skeletal muscle aging and the development of sarcopenia, a condition characterized by the progressive loss of muscle mass, strength, and function.
Yang Li, Huating Wang
doaj   +1 more source

Enhancing adipose tissue functionality in obesity: senotherapeutics, autophagy and cellular senescence as a target

Obesity, a global health crisis, disrupts multiple systemic processes, contributing to a cascade of metabolic dysfunctions by promoting the pathological expansion of visceral adipose tissue (VAT).
Arias, Consuelo, Kerr, Bredford, Javiera Álvarez-Indo, Burgos, Patricia V., Bredford Kerr, Mariana Cifuentes, Morselli, Eugenia, Consuelo Arias, Cifuentes, Mariana, Eugenia Morselli, Álvarez-Indo, Javiera, Patricia V. Burgos   +11 more
core   +1 more source

The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action

Pharmaceuticals
Background: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova, Giovanna Baron, Paolo Morazzoni, Giancarlo Aldini, Francesca Gado   +4 more
doaj   +1 more source

Engineering nanoformulations for senotherapeutics delivery

Mauro Rodrigo Dias Henriques
openaire   +3 more sources