Results 71 to 80 of about 1,366 (168)

Use of senotherapeutics in the treatment of chronic pulmonary diseases

, 2022
Kod kroničnih plućnih bolesti postoje nakupine senescentnih stanica. Senoterapeutici djeluju na sam uzrok bolesti i time se sprječava progresija plućnih bolesti. Senolitici su lijekovi koji potiču apoptozu senescentnih stanica.
Stokanović, Tihana
core  

Lipid‐ and Polymer‐Based Nanoscale Delivery of Anti‐Aging Phytochemicals

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 3, May/June 2026.
Oral delivery of phytobioactive compounds (PCBs) through nano‐drug delivery systems (NDDSs). These delivery systems enhance oral bioavailability of phytobioactive compounds by (i) increasing protection from the harsh gastrointestinal tract environment, (ii) enhancing aqueous solubility, (iii) enhancing interactions with epithelial cells, allowing for ...
Sarah Gross, Charlotte Vogtlander, Caitlin Lewis, Edward van Harmelen, Alexandra Stolzing, Norbert Radacsi   +5 more
wiley   +1 more source

New perspectives on the physiological basis of muscle loss

Experimental Physiology, EarlyView.
Alistair J. Monteyne, Marlou L. Dirks
wiley   +1 more source

Table1_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.XLSX

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

Cell Senescence in Heterotopic Ossification

Biomolecules
The formation of bone outside the normal skeleton, or heterotopic ossification (HO), occurs through genetic and acquired mechanisms. Fibrodysplasia ossificans progressiva (FOP), the most devastating genetic condition of HO, is due to mutations in the ...
Robert J. Pignolo, Frederick S. Kaplan, Haitao Wang   +2 more
doaj   +1 more source

Transcriptional Profiling at Single‐Cell Resolution Reveals Diversity and Regulatory Networks of Primary and Secondary Senescent Cells

Aging Cell, Volume 25, Issue 5, May 2026.
The research article “Transcriptional Profiling at Single‐cell Resolution Reveals Diversity and Regulatory Networks of Primary and Secondary Senescent Cells” by Jang, Shim, et al. models primary senescence by X‐ray irradiation and secondary senescence by conditioned media transfer in human renal epithelial cells. Single‐cell RNA‐seq identifies distinct
Dong‐Hyun Jang, Eunha Shim, Ji‐Won Shin, Seokho Kim, Serban Ciotlos, Hyun Jung Kim, Tae‐Hwan Gil, Yumin Kim, Ok Hee Jeon   +8 more
wiley   +1 more source

The potential for senotherapy as a novel approach to extend life quality in veterinary medicine

Frontiers in Veterinary Science
Cellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans.
Zoë J. Williams, Lyndah Chow, Steven Dow, Steven Dow, Lynn M. Pezzanite   +4 more
doaj   +1 more source

Skin Glycomics: Unmasking the Role of Glycation End Products in Cutaneous Aging and Dermatology

Journal of Cosmetic Dermatology, Volume 25, Issue 5, May 2026.
ABSTRACT Background Skin aging is a multifactorial process influenced by intrinsic and extrinsic factors. Beyond photoaging and oxidative stress, glycation and advanced glycation end products (AGEs) are increasingly recognized as key drivers of cutaneous senescence.
Diala Haykal
wiley   +1 more source

DataSheet1_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.PDF

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

The Regulation of Cellular Senescence in Cancer

Biomolecules
Cellular senescence is a stable state of cell cycle arrest caused by telomere shortening or various stresses. After senescence, cells cease dividing and exhibit many age-related characteristics. Unlike the halted proliferation of senescence cells, cancer
Xianhong Zhang, Yue Gao, Siyu Zhang, Yixiong Wang, Yitian Du, Shuailin Hao, Ting Ni   +6 more
doaj   +1 more source