Results 71 to 80 of about 1,649 (193)
Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity [PDF]
, 2023 Brain vascular health appears to be critical for preventing the development of amyotrophic lateral sclerosis (ALS) and slowing its progression. ALS patients often demonstrate cardiovascular risk factors and commonly suffer from cerebrovascular disease ...
Arndt, Philipp +16 more
core +2 more sources
Journal of Cellular Physiology, Volume 241, Issue 4, April 2026.ABSTRACT Dental caries is a prevalent oral health problem that significantly reduces an individual's quality of life; although, it can be effectively managed through restorative treatments. Even in cases where the caries does not reach the pulp, released microbial products from the lesion can still penetrate the pulp chamber, potentially inducing ...
Sebahat Melike Durukan +13 more
wiley +1 more source
Therapy-induced senescence in breast cancer: an overview
Exploration of Targeted Anti-tumor TherapyOutcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present with intrinsic drug resistance and others are initially sensitive to anti-cancer drugs but acquire resistance during the course of their ...
Suraj Narayanan Chembukavu +1 more
doaj +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.By comparing plasma proteomes of young and older adults, as well as older adults with varying levels of disease burden, this study aims to identify plasma proteins at the intersection of age and disease. The identified signature points to potential candidate biomarkers of biological aging.
Juliette Tavenier +9 more
wiley +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.Glioblastoma cells induced to senescence by Temozolomide are heterogeneous, with the emergence of two main states, named E‐state and F‐state, which differ in cellular morphometry, survival mechanisms, and sensitivity to autophagy modulators and senolytics. These states are dynamic, with the occurrence of morphofunctional transitions.
Solon Andrades da Rosa +12 more
wiley +1 more source
The senotherapeutic potential of phytochemicals for age-related intestinal disease [PDF]
During the last few decades, life expectancy has increased worldwide along with the prevalence of several age-related diseases. Among aging pathways, cellular senescence and chronic inflammation (or “inflammaging”) appear to be connected to gut ...
Costa, Célia Maria +4 more
core +1 more source
New perspectives on the physiological basis of muscle loss
Experimental Physiology, EarlyView.
Alistair J. Monteyne, Marlou L. Dirks
wiley +1 more source
Aging Cell, Volume 25, Issue 4, April 2026.Longitudinal senescence profiling in AppNL‐G‐F Alzheimer's mice reveals progressive microglial and astrocytic senescence (p16/p21 upregulation, morphological impairment, SA‐β‐galactosidase activity, and elevated IL‐1β and IL‐6) without neuronal senescence.
Eileen Mac Sweeney +7 more
wiley +1 more source
Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia
JCI InsightCachexia is a debilitating skeletal muscle wasting condition for which we currently lack effective treatments. In the context of cancer, certain chemotherapeutics cause DNA damage and cellular senescence. Senescent cells exhibit chronic activation of the transcription factor NF-κB, a known mediator of the proinflammatory senescence-associated secretory
Davis A. Englund +13 more
openaire +2 more sources