Results 91 to 100 of about 1,649 (193)

Astrocyte Senescence Impairs Synaptogenesis due to Thrombospondin‐1 Loss

Aging Cell, Volume 25, Issue 2, February 2026.
Senescent hippocampal astrocytes lose TSP secretion, impairing excitatory synaptogenesis via the α2δ‐1 pathway. Restoring TSP‐1 rescues synaptic formation, revealing the contribution of astrocyte senescence to age‐related hippocampal synaptic decline.
Stefano Ercoli, Lucía Casares‐Crespo, Elena Juárez‐Escoto, Helena Mira   +3 more
wiley   +1 more source

A Scalable Organoid Model of Urothelial Aging for Metabolic Interrogation, Infection Modeling, and Reversal of Age‐Associated Changes

Aging Cell, Volume 25, Issue 2, February 2026.
mBEDOs: a scalable platform for modeling urothelial aging. mBEDOs derived from aged mouse bladders capture essential molecular and cellular features of urothelial aging and provide a versatile system for high‐throughput metabolic profiling, therapeutic screening via metabolite supplementation, age‐ and sex‐based analyses, infection modeling, and immune–
Adwaita R. Parab, Arnold M. Salazar, Steven J. Bark, Margarita Divenko, Vasanta Putluri, D'Feau J. Lieu, Aadya S. Singh, Nagireddy Putluri, Indira U. Mysorekar   +8 more
wiley   +1 more source

SGLT2 inhibitors as a novel senotherapeutic approach

npj Aging
Abstract Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues and organs with aging contribute to many chronic diseases, mainly through the secretion of a pro-inflammatory senescence-associated secretory phenotype (SASP).
Zeynep Elif Yesilyurt-Dirican, Ce Qi, Yi-Chian Wang, Annika Simm, Laura Deelen, Alia Hafiz Abbas Gasim, Fiona Lewis-McDougall, Georgina M. Ellison-Hughes   +7 more
openaire   +2 more sources

Senotherapeutic drugs for human intervertebral disc degeneration and low back pain

eLife, 2020
Cellular senescence is a contributor to intervertebral disc (IVD) degeneration and low back pain. Here, we found that RG-7112, a potent mouse double-minute two protein inhibitor, selectively kills senescent IVD cells through apoptosis. Gene expression pathway analysis was used to compare the functional networks of genes affected by RG-7112, a pure ...
Hosni Cherif, Daniel G Bisson, Matthew Mannarino, Oded Rabau, Jean A Ouellet, Lisbet Haglund   +5 more
openaire   +3 more sources

Investigating the bidirectional interactions between senotherapeutic agents and human gut microbiota [PDF]

Biological ageing is a time-dependent process that has implications for health and disease. Cellular senescence is a key driver in ageing and age-related diseases.
Basit, Abdul W, Favaron, Alessia, Gaisford, Simon, Mai, Yang, McCoubrey, Laura E, Sangfuang, Nannapat, Taub, Marissa, Xie, Yuan   +7 more
core  

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog [PDF]

The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging.
Boukos, Nikos, Evangelou, Konstantinos, Georgiou, Maria, Gorgoulis, Vassilis G., Havaki, Sophia, Kambas, Konstantinos, Kotopoulos, Nicholas, Kotsinas, Athanassios, Lagopati, Nefeli, Lougiakis, Nikolaos, Magkouta, Sophia, Marakos, Panagiotis, Palaiologou, Anastasia, Papaspyropoulos, Angelos, Petty, Russell, Pippa, Natassa, Pispas, Stergios, Pouli, Nicole, Sampaziotis, Fotios, Tamvakopoulos, Constantin, Thanos, Dimitris, Thanos, Dimitris Foivos, Veroutis, Dimitris   +22 more
core   +2 more sources

Revolutionizing Aging: The Dawn of Longevity Medicine and Lifespan Extension [PDF]

Ageing, conventionally measured as an inevitable biological process, is one of the major areas of leading-edge scientific research. Nowadays, the field of senolytics, telomere extension and other cellular rejuvenation techniques intended at tackling ...
Irfan, Asma
core   +2 more sources

Senotherapeutic potential against xeroderma pigmentosum

AbstractXeroderma pigmentosum (XP) is an inherited photoaging syndrome caused by mutations in genes involved in the nucleotide excision repair (NER) pathway. XP patients exhibit hypersensitivity to ultraviolet (UV) radiation, leading to accelerated skin aging and requiring lifelong sun avoidance. Here, we demonstrate that UV-induced DNA damage triggers
Xuebing Wang, Masako Nishida, Ai Yoshioka, Claire Yik-Lok Chung, Shinya Hashimoto, Hideki Tanizawa, Shinya Ohta, Ken-ichi Noma, Takeshi Fukumoto   +8 more
openaire   +1 more source

Cellular senescence in cancer: molecular mechanisms and therapeutic targets

MedComm
Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes.
Ping Jin, Xirui Duan, Lei Li, Ping Zhou, Cheng‐Gang Zou, Ke Xie   +5 more
doaj   +1 more source

Health equity engineering: Optimizing hope for a new generation of healthcare [PDF]

Medical researchers are increasingly prioritizing the inclusion of underserved communities in clinical studies. However, mere inclusion is not enough. People from underserved communities frequently experience chronic stress that may lead to accelerated ...
Balls-Berry, Joyce E, Enders, Felicity T, et al.,   +2 more
core   +3 more sources