Results 91 to 100 of about 1,366 (168)

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Clinical and Translational Medicine
Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong, Lu Dong, Qiongying Lv, Yutong Yin, Jiahui Zhao, Youning Ke, Shixuan Wang, Wei Zhang, Meng Wu   +8 more
doaj   +1 more source

Therapy-induced senescence through the redox lens

Redox Biology
Therapy-induced senescent tumor cells have emerged as significant drivers of tumor recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production and its associated redox signaling networks are intertwined with initiation and ...
Matius Robert, Brian K. Kennedy, Karen C. Crasta   +2 more
doaj   +1 more source

Editorial: Cellular Senescence: Causes, Consequences and Therapeutic Opportunities

Frontiers in Cell and Developmental Biology, 2022
Pooi-Fong Wong
doaj   +1 more source

Epigenetic dysregulation in cardiovascular aging and disease

, 2021
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity for all sexes, racial and ethnic groups. Age, and its associated physiological and pathological consequences, exacerbate CVD incidence and progression, while modulation of ...
Occean, James R., Herman, Allison B., Sen, Payel   +2 more
core  

Connecting epigenetics and inflammation in vascular senescence: state of the art, biomarkers and senotherapeutics

Frontiers in Genetics
Vascular diseases pose major health challenges, and understanding their underlying molecular mechanisms is essential to advance therapeutic interventions. Cellular senescence, a hallmark of aging, is a cellular state characterized by cell-cycle arrest, a
Oscar Fraile-Martinez, Oscar Fraile-Martinez, Diego De Leon-Oliva, Diego De Leon-Oliva, Diego Liviu Boaru, Diego Liviu Boaru, Patricia De Castro-Martinez, Patricia De Castro-Martinez, Cielo Garcia-Montero, Cielo Garcia-Montero, Silvestra Barrena-Blázquez, Silvestra Barrena-Blázquez, Joaquin García-García, Natalio García-Honduvilla, Natalio García-Honduvilla, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Melchor Alvarez-Mon, Laura Lopez-Gonzalez, Laura Lopez-Gonzalez, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Raul Diaz-Pedrero, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Luis G. Guijarro, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega, Miguel A. Ortega   +31 more
doaj   +1 more source

The Emerging Field of Senotherapeutic Drugs [PDF]

Future Medicinal Chemistry, 2018
openaire   +3 more sources

SENOTHERAPEUTICS, AGING, AND AGE-RELATED DISEASES [PDF]

Innov Aging
Abstract Increased translational clinical trials are addressing the utility of senotherapeutic agents as interventions for aging in general and for age-related diseases. Numerous pre-clinical trials have provided a good rationale for human clinical trials which are being increasingly proposed.
europepmc   +2 more sources

Senotherapeutic potential against xeroderma pigmentosum

Abstract Xeroderma pigmentosum (XP) is an inherited photoaging syndrome caused by mutations in genes involved in the nucleotide excision repair (NER) pathway. XP patients exhibit hypersensitivity to ultraviolet (UV) radiation, leading to accelerated skin aging and requiring lifelong sun avoidance.
Xuebing Wang, Masako Nishida, Ai Yoshioka, Claire Yik-Lok Chung, Shinya Hashimoto, Hideki Tanizawa, Shinya Ohta, Ken-ichi Noma, Takeshi Fukumoto   +8 more
openaire   +1 more source

Insights on geroscience pre-clinical and clinical trials to promote healthy aging from the Intrinsic Capacity, Frailty and Sarcopenia Research Task Force 2025. [PDF]

J Frailty Aging
Tagliafico L, Canevelli M, Barreto PS, Cesari M, Ferrucci L, Vellas B, Rolland Y, ICFSR Task Force.   +7 more
europepmc   +1 more source

Real-World Clinical Practice on Skin Rejuvenation Among Korean Board-Certified Dermatologists: Survey-Based Results. [PDF]

Ann Dermatol
Oh S, Kim YH, Kim BR, Seo HM, Kwon SH, Choi H, Lee H, Na JI, Choi CP, Ko JY, Ryu HJ, Seo SB, Lee JH, Kim HS, Huh CH.   +14 more
europepmc   +1 more source