Results 91 to 100 of about 416 (129)
Senotherapeutics: Experimental therapy of cellular senescence
, 2021 Laura J. Niedernhofer +2 more
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Senotherapeutics for healthy ageing [PDF]
Nature Reviews Drug Discovery, 2018 Laura Niedernhofer, Paul Robbins
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Senotherapeutics for mesenchymal stem cell senescence and rejuvenation
Drug Discovery Today, 2023 Mesenchymal stem cells (MSCs) are susceptible to replicative senescence and senescence-associated functional decline, which hampers their use in regenerative medicine. Senotherapeutics are drugs that target cellular senescence through senolytic and senomorphic functions to induce apoptosis and suppress chronic inflammation caused by the senescence ...
Pooi-Fong Wong, Thamil Selvee Ramasamy
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Senescence and senotherapeutics: a new field in cancer therapy
Pharmacology & Therapeutics, 2019 Cellular senescence is a stress response mechanism ensuring homeostasis. Its temporal activation during embryonic development or normal adult life is linked with beneficial properties. In contrast, persistent (chronic) senescence seems to exert detrimental effects fostering aging and age-related disorders, such as cancer.
Gerassimos Pangalis +2 more
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Cancers, 2021 Simple Summary Recent scientific discoveries identify cell senescence as pivotal in hepatocellular cancer (HCC) biology. Specifically, hepatitis B virus (HBV), hepatitis C virus (HCV) and non-alcoholic fatty liver disease (NAFLD) are major risk factors ...
Eleni Papoutsi, Peter Dubovan
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Senotherapeutics for metabolic disease and diabetic complications
Journal of Internal MedicineAbstract Metabolic diseases, including obesity, Type 2 diabetes (T2D), and metabolic syndrome, are increasingly prevalent worldwide, driven by sedentary lifestyles, aging populations, and complex genetic and environmental factors. Traditionally understood as disorders of glucose and lipid metabolism, a growing body of evidence now ...
Ulf Smith +2 more
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Osteoarthritis in time for senotherapeutics
Joint Bone Spine, 2021Jean-Marc Brondello +1 more
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Recent Advances in Senotherapeutics Delivery
Tissue Engineering - Part B: Reviews, 2022Accumulation of senescent cells (SnCs) in various tissue types has been connected to an occurrence of different age-related diseases that are indicated by its own tissue-specific hallmarks. Discovery of novel senolytic compounds that target major cellular mechanisms to inhibit the level of SnCs within the specific tissues or organs
Guang Yang, John Fisher, Ji Young Choi
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