Editorial: Cellular Senescence: Causes, Consequences and Therapeutic Opportunities
Frontiers in Cell and Developmental Biology, 2022 Pooi-Fong Wong
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Senescence of skeletal stem cells and their contribution to age-related bone loss [PDF]
Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone ...
Elkjær, Anna Sofie +7 more
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Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging [PDF]
Ageing is accompanied by a decline in immune function (immunosenescence), increased inflammation (inflammaging), and more senescent cells which together contribute to age-related disease and infection susceptibility. The innate immune system is the front-
Chen, Yung-Yi +3 more
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MetabolitesChronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
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Do Sleeper Cells Hold the Key to Immortality? Senescent cells in cancer and aging [PDF]
, 2023 Aldridge, Kristin
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Senescence and fibrosis in salivary gland aging and disease
Journal of Oral Biology and Craniofacial ResearchSalivary gland hypofunction is highly prevalent in aged and diseased individuals leading to significant discomfort and morbidity. One factor that contributes to salivary gland hypofunction is cellular aging, or senescence.
Deirdre A. Nelson +3 more
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A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression
Reproductive Biology and EndocrinologyEndometriosis is an estrogen-dependent chronic inflammatory disease, however the mechanisms underlying inflammation remain unclear. Non-hormonal drugs that can prevent endometriosis progression and resolve endometriotic infertility are urgently required. We thus focused on cellular senescence as a novel feature of endometriosis.
Reina Sonehara +11 more
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The Emerging Field of Senotherapeutic Drugs [PDF]
Future Medicinal Chemistry, 2018 openaire +3 more sources
The impacts of endothelial cell senescence on ageing-related blood-brain barrier dysfunction and the potential therapeutic strategies [PDF]
Background: Disruption of the blood-brain barrier (BBB) contributes to various agerelated neurological disorders. Brain microvascular endothelial cells (BMECs) are the most critical components of the BBB, forming a tightly sealed yet selectively ...
Ya, Jingyuan
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Chronic Use of Azithromycin Might Explain the Low Prevalence of COVID-19 in Cystic Fibrosis Patients [PDF]
, 2020 Sara, Galimberti
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