Results 101 to 110 of about 1,649 (193)
Senotherapeutics: emerging strategy for healthy aging and age-related disease
BMB Reports, 2019 Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells (SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of diverse age-related diseases (ARDs). Genetic ablation of SCs in tissues lengthened health span and reduced the risk of age-related pathologies in a mouse model ...
Kim, Eok-Cheon, Kim, Jae-Ryong
openaire +3 more sources
PharmaceuticalsBackground: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova +4 more
doaj +1 more source
Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Aging and diseaseDiabetic foot ulcers (DFUs) are a prevalent and profoundly debilitating complication that afflicts individuals with diabetes mellitus (DM). These ulcers are associated with substantial morbidity, recurrence rates, disability, and mortality, imposing substantial economic, psychological, and medical burdens. Timely detection and intervention can mitigate
Zhang, Guiqin +12 more
openaire +2 more sources
Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies [PDF]
A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely in their sensitivity ...
Alarcón Cor, Tomás +13 more
core +1 more source
Cellular senescence in chronic obstructive pulmonary disease: Molecular mechanisms and therapeutic interventionsa. [PDF]
Chronic obstructive pulmonary disease (COPD) is the world's fourth highest reason for mortality, accounting for 3.5 million deaths in 2021, and about 5% of total global deaths.
Bashyal, S +10 more
core +1 more source
Clinical and Translational MedicineTumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong +8 more
doaj +1 more source
SENOTHERAPEUTICS, AGING, AND AGE-RELATED DISEASES [PDF]
Innov AgingAbstract Increased translational clinical trials are addressing the utility of senotherapeutic agents as interventions for aging in general and for age-related diseases. Numerous pre-clinical trials have provided a good rationale for human clinical trials which are being increasingly proposed.
europepmc +2 more sources
Screening for senolytic and senomorphic compounds in HDF76 fibroblasts and their effects as geroprotectors in C. elegans [PDF]
El envejecimiento es el principal factor de riesgo para muchas enfermedades, y la senescencia celular es un factor clave en este proceso y sus patologías relacionadas.
Sanguinet Rumayor, Sybila
core
Therapy-induced senescence through the redox lens
Redox BiologyTherapy-induced senescent tumor cells have emerged as significant drivers of tumor recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production and its associated redox signaling networks are intertwined with initiation and ...
Matius Robert +2 more
doaj +1 more source
Senescence profiling of monoclonal gammopathies reveals paracrine senescence as a crucial defense against disease progression [PDF]
Multiple myeloma (MM) is a plasma cell (PC) malignancy that is preceded by monoclonal gammopathy of undetermined significance (MGUS) and/or smoldering multiple myeloma (SMM).
Abdallah, Nadine +17 more
core +1 more source