Results 101 to 110 of about 416 (129)
Senotherapeutics and Their Molecular Mechanism for Improving Aging
Biomolecules and Therapeutics, 2022 Aging is defined as physiological dysfunction of the body and a key risk factor for human diseases. During the aging process, cellular senescence occurs in response to various extrinsic and intrinsic factors such as radiation-induced DNA damage, the activation of oncogenes, and oxidative stress.
Jooho Park, Dong Wook Shin
exaly +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Senotherapeutics and HIV-1 Persistence
Current HIV/AIDS Reports, 2020To review the potential use of senotherapeutics, pharmacologic agents that target senescent cells, in addressing HIV-1 persistence.Treated HIV-1 infection results in a state of immune exhaustion, which may involve reprogramming of infected and bystander cells toward a state of cellular senescence.
Matthew Szaniawski, Adam Spivak
exaly +3 more sources
Mitochondria-targeted senotherapeutic interventions
Biogerontology, 2022Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the factors that make life difficult with aging, and on the other side are the products of human effort against these factors. The most important factors that make the life difficult with aging are age-related disorders. Developing senotherapeutic strategies may
Mehmet Can Atayik, Ufuk Çakatay
openaire +4 more sources
Senotherapeutics in Malignant Brain Cancer Therapy
Current Oncology ReportsAbstract Purpose of Review Malignant brain cancer, the most severe form is glioblastoma (GBM), has a dismal prognosis, despite maximal resection followed by radio-chemotherapy. First line therapeutics are alkylating drugs, notably the DNA-methylating temozolomide (TMZ), administered ...
Bernd Kaina, Markus Christmann
exaly +4 more sources
Cellular parabioisis as a senotherapeutic approach
Beyond cell death and differentiation, cell senescence is profoundly influenced by the social nature of cells, which is intricately linked to cell communication as a fundamental aspect of biological systems shaping both individual and collective cellular behaviors.Sencan, Sevide, Onaran, Ilhan
openaire +2 more sources
Targeting the microbiota-mitochondria crosstalk in neurodegeneration with senotherapeutics
2023Neurodegenerative diseases are a group of age-related disorders characterized by a chronic and progressive loss of function and/or structure of synapses, neurons, and glial cells. The etiopathogenesis of neurodegenerative diseases is characterized by a complex network of intricately intertwined pathophysiological processes that are still not fully ...
openaire +2 more sources
Revolutionizing cancer treatment with senotherapeutics: a current perspective
Cancer Chemotherapy and PharmacologyCellular senescence is a double-edged sword in cancer biology, initially acting as a tumor-suppressive mechanism but later contributing to cancer progression and therapy resistance. Senescent cells, characterized by stable cell cycle arrest, secrete a complex array of bioactive molecules known as the senescence-associated secretory phenotype (SASP ...
Lakshika Singh +5 more
openaire +2 more sources
Stem cell-derived extracellular vesicles as senotherapeutics
Ageing Research ReviewsCellular senescence (CS) is recognized as one of the hallmarks of aging, and an important player in a variety of age-related pathologies. Accumulation of senescent cells can promote a pro-inflammatory and pro-cancerogenic microenvironment. Among potential senotherapeutics are extracellular vesicles (EVs) (40-1000 nm), including exosomes (40-150 nm ...
Ekaterina, Rudnitsky +6 more
openaire +2 more sources