Results 1 to 10 of about 9,248 (241)
MoleculesThe accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the
Shao-Xing Dai, Min Xu, Li Jinjun
exaly +5 more sources
Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?
BiomoleculesAging is a predominant risk factor for cardiovascular diseases. There is evidence demonstrating that senescent cells not only play a significant role in organism aging but also contribute to the pathogenesis of cardiovascular diseases in younger ages ...
Zhihong Yang +2 more
doaj +2 more sources
Frontiers in MedicineIntroductionChronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Jonathan R. Baker +6 more
doaj +2 more sources
Senolytic drugs: from discovery to translation [PDF]
Journal of Internal Medicine, 2020 Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven approach.
J. Kirkland, T. Tchkonia
semanticscholar +3 more sources
Targeting cIAP2 in a novel senolytic strategy prevents glioblastoma recurrence after radiotherapy
EMBO Molecular MedicineGlioblastomas (GBM) are routinely treated with high doses of ionizing radiation (IR), yet these tumors recur quickly, and the recurrent tumors are highly therapy resistant.
Andrea Gilbert +2 more
exaly +2 more sources
The Journal of Clinical InvestigationThere is intense interest in identifying compounds that selectively kill senescent cells, termed senolytics, for ameliorating age-related comorbidities.
Sundeep Khosla
doaj +3 more sources
Senolytic Therapy Enabled by Senescent Cell‐Sensitive Biomimetic Melanin Nano‐Senolytics
Advanced Healthcare MaterialsCellular senescence is a significant risk factor for aging and age‐related diseases (ARD). The canonical senolytics Dasatinib and Quercetin (DQ) have shown promise in clearing senescent cells (SnCs); however, the lack of selectivity poses a challenge in ...
Hairui Zhang +10 more
semanticscholar +3 more sources
Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging
Frontiers in Aging NeuroscienceThere are sex differences in vulnerability and resilience to the stressors of aging and subsequent age-related cognitive decline. Cellular senescence occurs as a response to damaging or stress-inducing stimuli.
Thomas C Foster +2 more
exaly +3 more sources
Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells
Frontiers in Cell and Developmental BiologyMalignant Melanoma that resists immunotherapy remains the deadliest form of skin cancer owing to poor clinically lasting responses. Alternative like genotoxic or targeted chemotherapy trigger various cancer cell fates after treatment including cell death
Nicolas Malaquin +2 more
exaly +3 more sources
Aging Cell, 2023 Aging results in an elevated burden of senescent cells, senescence‐associated secretory phenotype (SASP), and tissue infiltration of immune cells contributing to chronic low‐grade inflammation and a host of age‐related diseases.
M. Islam +7 more
semanticscholar +1 more source