Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence [PDF]
Cell Death DiscoveryMitochondria integrate senescence and apoptotic fates, yet it is unclear whether their ability to oxidize different fuels for energy production influences their vulnerability to senolytics in therapy-induced senescence (TIS). Using MitoPlates™ technology,
Àngela Llop-Hernández +5 more
doaj +2 more sources
Redox Biology, 2020 Cellular senescence may contribute to aging and age-related diseases and senolytic drugs that selectively kill senescent cells may delay aging and promote healthspan.
Anna Lewinska +2 more
exaly +3 more sources
Senolytic therapy reduces inflammation in epithelial cells from COPD patients and in smoke-exposure mice [PDF]
Frontiers in MedicineIntroductionChronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Jonathan R. Baker +6 more
doaj +3 more sources
Identification and characterization of Cardiac Glycosides as senolytic compounds [PDF]
Nature Communications, 2019 Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions.
Francisco Triana-Martinez +2 more
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Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging
Frontiers in Aging NeuroscienceThere are sex differences in vulnerability and resilience to the stressors of aging and subsequent age-related cognitive decline. Cellular senescence occurs as a response to damaging or stress-inducing stimuli.
Thomas Foster, Ashok Kumar
exaly +3 more sources
COVID-19 and chronological aging : senolytics and other anti-aging drugs for the treatment or prevention of corona virus infection? [PDF]
, 2020 COVID-19, also known as SARS-CoV-2, is a new emerging zoonotic corona virus of the SARS (Severe Acute Respiratory Syndrome) and the MERS (Middle East Respiratory Syndrome) family.
Auwerx +30 more
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344 The Potential Benefits of Using Senolytics in Colorectal Cancer Treatment
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Anti-cancer therapies, such as chemotherapy, can induce senescence. Senescent cells may produce factors that can promote tumor progression.
Valerie Gallegos +6 more
doaj +1 more source
Improvement of the ability of bone repair by reducing the aging degree of mesenchymal stem cell population by Senolytic drugs [PDF]
E3S Web of Conferences, 2021 In order to study the effects of Senolytic drugs dasatinib and quercetin on the aging of mesenchymal stem cells (MSCs) and explore the application of young MSCs in repairing bone defects, the cultured and identified MSCs were treated with dasatinib and ...
Liu Jia, He Lian, Zhou Peng, Chen Danna
doaj +1 more source
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
core +1 more source
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source