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POLY-Senolytic nanoplatform for tumor-specific eradication of senescent tumor cells and mitigation of radiotherapy-induced immune resistance of cancer [PDF]
Nature CommunicationsRadiotherapy (RT) efficacy is limited by RT-induced immune resistance. Here we show that RT upregulates programmed death ligand 1 (PD-L1) on senescent tumor cells (STCs) via bromodomain-containing protein 4 (BRD4) signaling, thereby promoting immune ...
Yi Lai +11 more
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Cellular senescence and senolytic therapy in traumatic brain injury [PDF]
Frontiers in NeuroscienceTraumatic brain injury (TBI) is a major cause of death and long-term disability in the United States. The initial primary injury in TBI is followed by a secondary injury cascade of molecular events, which can persist for years, and contributes to ...
Darrell W. Brann +5 more
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MoleculesThe accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the
Min Xu, Shao-Xing Dai, Guotai Yang
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Failure of Senolytic Treatment to Prevent Cognitive Decline in a Female Rodent Model of Aging
Frontiers in Aging NeuroscienceThere are sex differences in vulnerability and resilience to the stressors of aging and subsequent age-related cognitive decline. Cellular senescence occurs as a response to damaging or stress-inducing stimuli.
Vivekananda Budamagunta, Asha Rani
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Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
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Frontiers in Cardiovascular Medicine, 2021 Background: Following an acute coronary syndrome, patients display an elevated inflammatory profile, promoted in part by cellular senescence. For patients requiring a coronary artery bypass (CABG) surgery, exposure to the surgical intervention and ...
Olina Dagher +12 more
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Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
Frontiers in Cell and Developmental Biology, 2022 Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in ...
Li Hu +12 more
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Evaluating the neuroprotective impact of senolytic drugs on human vision
Scientific Reports, 2020 Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression.
Nevin W. El-Nimri +6 more
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344 The Potential Benefits of Using Senolytics in Colorectal Cancer Treatment
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Anti-cancer therapies, such as chemotherapy, can induce senescence. Senescent cells may produce factors that can promote tumor progression.
Valerie Gallegos +6 more
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