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MoleculesThe accumulation of senescent cells is a major contributor to aging and various age-related diseases, making developing senolytic compounds that are capable of clearing these cells an important area of research. However, progress has been hampered by the
Min Xu, Shao-Xing Dai
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Evaluating the neuroprotective impact of senolytic drugs on human vision
Scientific Reports, 2020 Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression.
Nevin W. El-Nimri +6 more
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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
Frontiers in Cell and Developmental Biology, 2022 Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in ...
Daohong Zhou +2 more
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Frontiers in Cell and Developmental Biology, 2020 Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but chronic senescence, as in aging, can contribute to the development of age-related tissue dysfunction and disease.
Jessica Pierce +2 more
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Failure of senolytic treatment to prevent cognitive decline in a female rodent model of aging
Frontiers in Aging NeuroscienceThere are sex differences in vulnerability and resilience to the stressors of aging and subsequent age-related cognitive decline. Cellular senescence occurs as a response to damaging or stress-inducing stimuli.
Vivekananda Budamagunta
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Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells
Frontiers in Cell and Developmental BiologyMalignant Melanoma that resists immunotherapy remains the deadliest form of skin cancer owing to poor clinically lasting responses. Alternative like genotoxic or targeted chemotherapy trigger various cancer cell fates after treatment including cell death
Nicolas Malaquin +2 more
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344 The Potential Benefits of Using Senolytics in Colorectal Cancer Treatment
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Anti-cancer therapies, such as chemotherapy, can induce senescence. Senescent cells may produce factors that can promote tumor progression.
Valerie Gallegos +6 more
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Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
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Frontiers in Cardiovascular Medicine, 2021 Background: Following an acute coronary syndrome, patients display an elevated inflammatory profile, promoted in part by cellular senescence. For patients requiring a coronary artery bypass (CABG) surgery, exposure to the surgical intervention and ...
Olina Dagher +12 more
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Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
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