Results 31 to 40 of about 2,081 (185)
Death-seq identifies regulators of cell death and senolytic therapies [PDF]
, 2023 Selectively ablating damaged cells is an evolving therapeutic approach for age-related disease. Current methods for genome-wide screens to identify genes whose deletion might promote the death of damaged or senescent cells are generally underpowered ...
Julian D.D. Klein +37 more
core +1 more source
Recent advances in the discovery of senolytics
Mechanisms of Ageing and Development, 2021 The demonstration in model organisms that cellular senescence drives aging and age-related diseases has led to widespread efforts to identify compounds able to selectively kill senescent cells, termed senolytics. Approaches used to identify senolytics include bioinformatic analysis of senescent cell anti-apoptotic pathways (SCAPs) for drug development ...
Lei Zhang +4 more
openaire +3 more sources
Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. [PDF]
PLoS ONE, 2018 Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.
HyunTae V Hwang +4 more
doaj +1 more source
Identification and characterization of Digoxin as a novel senolytic drug [PDF]
, 2023 Cellular senescence is a potent protective response against several potentially dangerous stimuli that prevent the progression of damaged cells by inducing a stable proliferative arrest. In this way, cancer cells need to avoid this response in order to
Picallos Rabina, Mª del Pilar
core
Molecular Oncology, 2020 Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can contribute to unfavorable patient outcomes, potentially including disease relapse.
Tareq Saleh +10 more
doaj +1 more source
A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
Disease Models & Mechanisms, 2022 To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous ...
Pascual Torres +10 more
doaj +1 more source
Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice [PDF]
, 2023 IntroductionChronic neuroinflammation can exist for months to years following traumatic brain injury (TBI), although the underlying mechanisms remain poorly understood.MethodsIn the current study, we used a controlled cortical impact mouse model of TBI ...
Darrell W. Brann +4 more
core +1 more source
Oxidation resistance 1 is a novel senolytic target [PDF]
, 2018 The selective depletion of senescent cells (SCs) by small molecules, termed senolytic agents, is a promising therapeutic approach for treating age-related diseases and chemotherapy- and radiotherapy-induced side effects.
Remi-Martin Laberge +29 more
core +1 more source
Cellular Senescence: Molecular Targets, Biomarkers, and Senolytic Drugs
, 2022 Cellular senescence is defined as irreversible cell cycle arrest caused by various processes that render viable cells non-functional, hampering normal tissue homeostasis.
Natalie Kudlova +2 more
core +1 more source
Senescent cells: New target for an old treatment?
Molecular & Cellular Oncology, 2017 Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation.
Marco Demaria
doaj +1 more source