Results 31 to 40 of about 9,248 (241)
Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. [PDF]
PLoS ONE, 2018 Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.
HyunTae V Hwang +4 more
doaj +1 more source
A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
Disease Models & Mechanisms, 2022 To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous ...
Pascual Torres +10 more
doaj +1 more source
Effects of senolytic drugs on human mesenchymal stromal cells
Stem Cell Research & Therapy, 2018 Background Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effects of senolytic drugs have not been
Clara Grezella +5 more
doaj +1 more source
Cell & Bioscience, 2020 Background The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype.
Thanakorn Pungsrinont +6 more
doaj +1 more source
Senescence explains age- and obesity-related liver steatosis
Cell Stress, 2017 Cellular senescence, the irreversible loss of replicative potential of somatic cells, was first described in fibroblasts cultured in vitro by Leonard Hayflick more than 50 years ago.
Mikolaj Ogrodnik, Diana Jurk
doaj +1 more source
Galactose‐modified duocarmycin prodrugs as senolytics [PDF]
Aging Cell, 2019 Abstract Senescence is a stable growth arrest that impairs the replication of damaged, old or preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells accumulate during ageing and are associated with cancer, fibrosis and many age‐related pathologies.
Guerrero, Ana +7 more
openaire +6 more sources
NAD + , Senolytics, or Pyruvate for Healthy Aging? [PDF]
Nutrition and Metabolic Insights, 2021 In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD + ) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD +
openaire +3 more sources
Journal of Functional Biomaterials, 2022 Senescent cells accumulate in aged organisms and promote the progression of age-related diseases including cataracts. Therefore, we aimed to study the therapeutic effects of senescence-targeting drugs on cataracts.
Yinhao Wang +5 more
doaj +1 more source
A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called senolytics. Here, we fine-tuned a method for the identification of senolytics that is compatible with high-
Annunziata, Chiara +8 more
openaire +3 more sources
Is exercise a senolytic medicine? A systematic review [PDF]
Aging Cell, 2020 AbstractCellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years ...
Xiang‐Ke Chen +6 more
openaire +3 more sources