Nintedanib induces senolytic effect via STAT3 inhibition
Cell Death and Disease, 2022 Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even for reversing aging.
Hyun-Ji Cho +8 more
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Novel treatment strategies for chronic kidney disease: insights from the animal kingdom [PDF]
, 2018 Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these ...
Arnold, Walter +7 more
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Senolytic drugs: from discovery to translation [PDF]
Journal of Internal Medicine, 2020 AbstractSenolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis‐driven approach. SC accumulate with ageing and at causal sites of multiple chronic disorders, including diseases accounting for the bulk of morbidity, mortality ...
J. L. Kirkland, T. Tchkonia
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Investigation of quercetin and hyperoside as senolytics in adult human endothelial cells. [PDF]
PLoS ONE, 2018 Previously, quercetin has been reported to be a senolytic, a drug that selectively removes senescent cells, in HUVECs. However, we found neither quercetin nor Q3G was effective as a senolytic for adult human endothelial cells.
HyunTae V Hwang +4 more
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A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
Disease Models & Mechanisms, 2022 To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous ...
Pascual Torres +10 more
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Lipotoxicity, aging, and muscle contractility: does fiber type matter? [PDF]
, 2019 Sarcopenia is a universal characteristic of the aging process and is often accompanied by increases in whole-body adiposity. These changes in body composition have important clinical implications, given that loss of muscle and gain of fat mass are both ...
Carter, Christy S. +2 more
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CDKN2A/p16INK4a expression is associated with vascular progeria in chronic kidney disease [PDF]
, 2017 Patients with chronic kidney disease (CKD) display a progeric vascular phenotype linked to apoptosis, cellular senescence and osteogenic transformation. This has proven intractable to modelling appropriately in model organisms.
Bárány, Peter +13 more
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Early removal of senescent cells protects retinal ganglion cells loss in experimental ocular hypertension. [PDF]
, 2020 Experimental ocular hypertension induces senescence of retinal ganglion cells (RGCs) that mimics events occurring in human glaucoma. Senescence-related chromatin remodeling leads to profound transcriptional changes including the upregulation of a subset ...
Jabari, Mary +7 more
core
Cardiac glycosides are broad-spectrum senolytics [PDF]
Nature Metabolism, 2019 Senescence is a cellular stress response that results in the stable arrest of old, damaged or preneoplastic cells. Oncogene-induced senescence is tumor suppressive but can also exacerbate tumorigenesis through the secretion of pro-inflammatory factors from senescent cells.
Ana Guerrero +25 more
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Effects of senolytic drugs on human mesenchymal stromal cells
Stem Cell Research & Therapy, 2018 Background Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effects of senolytic drugs have not been
Clara Grezella +5 more
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