Results 11 to 20 of about 2,081 (185)
Cardiac Glycosides as Senolytic Compounds [PDF]
Trends in Molecular Medicine, 2020 The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts.
Martin, Nadine +2 more
openaire +3 more sources
Nintedanib induces senolytic effect via STAT3 inhibition
Cell Death and Disease, 2022 Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even for reversing aging.
Hyun-Ji Cho +8 more
doaj +2 more sources
Effects of senolytic drugs on human mesenchymal stromal cells
Stem Cell Research & Therapy, 2018 Background Senolytic drugs are thought to target senescent cells and might thereby rejuvenate tissues. In fact, such compounds were suggested to increase health and lifespan in various murine aging models. So far, effects of senolytic drugs have not been
Clara Grezella +5 more
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Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?
BiomoleculesAging is a predominant risk factor for cardiovascular diseases. There is evidence demonstrating that senescent cells not only play a significant role in organism aging but also contribute to the pathogenesis of cardiovascular diseases in younger ages ...
Zhihong Yang +2 more
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Cell Death DiscoveryMitochondria integrate senescence and apoptotic fates, yet it is unclear whether their ability to oxidize different fuels for energy production influences their vulnerability to senolytics in therapy-induced senescence (TIS). Using MitoPlates™ technology,
Àngela Llop-Hernández +5 more
doaj +2 more sources
Exploring the perspectives of pharmaceutical experts and healthcare practitioners on senolytic drugs for vascular aging-related disorder: a qualitative study [PDF]
Frontiers in Pharmacology, 2023 Objective: The field of targeting cellular senescence with drug candidates to address age-related comorbidities has witnessed a notable surge of interest and research and development.
Li Ping Wong +7 more
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PharmaceuticalsTherapeutically targeting senescent cells seems to be an interesting perspective in treating chronic lung diseases, which are often associated with human aging. The combination of the drug dasatinib and the polyphenol quercetin is used in clinical trials
Maria Carolina Ximenes de Godoy +2 more
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Chemistry ProceedingsLuteolin is a naturally occurring flavonoid with growing interest for its senolytic properties. However, its poor water solubility and low bioavailability limit clinical application.
Fawzia Sha’at +7 more
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Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic
, 2023 The accumulation of senescent cells has an important role in the phenotypical changes observed in ageing and in many age-related pathologies. Thus, the strategies designed to prevent these effects, collectively known as senotherapies, have a strong ...
M Poblocka (7809785) +7 more
core +7 more sources
A Review of Senolytic Drugs in Reducing the Biological Problems of Aging [PDF]
SālmandObjectives Considering the increase in the old adult population and age-related disorders, there is a need for strategies to reduce the complications of aging.
Sara Assadiasl +2 more
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