Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence [PDF]
Cell Death DiscoveryMitochondria integrate senescence and apoptotic fates, yet it is unclear whether their ability to oxidize different fuels for energy production influences their vulnerability to senolytics in therapy-induced senescence (TIS). Using MitoPlates™ technology,
Àngela Llop-Hernández +5 more
doaj +2 more sources
Correction to “Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza” [PDF]
Aging CellAging Cell, Volume 25, Issue 6, June 2026.
wiley +2 more sources
344 The Potential Benefits of Using Senolytics in Colorectal Cancer Treatment
Journal of Clinical and Translational Science, 2023 OBJECTIVES/GOALS: Anti-cancer therapies, such as chemotherapy, can induce senescence. Senescent cells may produce factors that can promote tumor progression.
Valerie Gallegos +6 more
doaj +1 more source
Improvement of the ability of bone repair by reducing the aging degree of mesenchymal stem cell population by Senolytic drugs [PDF]
E3S Web of Conferences, 2021 In order to study the effects of Senolytic drugs dasatinib and quercetin on the aging of mesenchymal stem cells (MSCs) and explore the application of young MSCs in repairing bone defects, the cultured and identified MSCs were treated with dasatinib and ...
Liu Jia, He Lian, Zhou Peng, Chen Danna
doaj +1 more source
Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
Nature Medicine, 2023 The first feasibility study of orally delivered senolytic therapy in Alzheimer’s disease reports favorable safety data and penetrance of dasatinib into the brain with a modest impact on Alzheimer’s and aging biomarkers. Cellular senescence contributes to
M. Gonzales +19 more
semanticscholar +1 more source
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Frontiers in Bioengineering and Biotechnology, 2022 Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar spondylosis. Over the past few years, the relevance between cellular senescence and IVDD has been widely studied, and the senescence-associated secretory phenotype (SASP ...
Yuhao Wu +16 more
doaj +1 more source
Frontiers in Cardiovascular Medicine, 2021 Background: Following an acute coronary syndrome, patients display an elevated inflammatory profile, promoted in part by cellular senescence. For patients requiring a coronary artery bypass (CABG) surgery, exposure to the surgical intervention and ...
Olina Dagher +12 more
doaj +1 more source
Evaluating the neuroprotective impact of senolytic drugs on human vision
Scientific Reports, 2020 Glaucoma, a chronic neurodegenerative disease of retinal ganglion cells (RGCs), is a leading cause of irreversible blindness worldwide. Its management currently focuses on lowering intraocular pressure to slow disease progression.
Nevin W. El-Nimri +6 more
doaj +1 more source
Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
doaj +1 more source
Cardiac Glycosides as Senolytic Compounds [PDF]
Trends in Molecular Medicine, 2020 The identification of senolytics, compounds that eliminate senescent cells, is presently a key priority given their therapeutic promise in cancer and aging-associated diseases. Two recent papers by Triana-Martínez et al. and Guerrero et al. report the senolytic activity of cardiac glycosides (CGs) and their efficacy in these pathophysiological contexts.
Martin, Nadine +2 more
openaire +2 more sources