Results 41 to 50 of about 2,081 (185)

Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan [PDF]

Innovation in Aging, 2020
Abstract Cellular senescence is a cell fate decision that is made by many mammalian cell types in response to damage, stress or certain physiological signals. Senescent cells arrest proliferation, essentially permanently, and develop a complex multi-component senescence-associated secretory phenotype (SASP).
openaire   +1 more source

Senolytic compounds control a distinct fate of androgen receptor agonist- and antagonist-induced cellular senescent LNCaP prostate cancer cells

Cell & Bioscience, 2020
Background The benefit of inducing cellular senescence as a tumor suppressive strategy remains questionable due to the senescence-associated secretory phenotype.
Thanakorn Pungsrinont, Malika Franziska Sutter, Maren C. C. M. Ertingshausen, Gopinath Lakshmana, Miriam Kokal, Amir Saeed Khan, Aria Baniahmad   +6 more
doaj   +1 more source

Reduction in Lens Epithelial Cell Senescence Burden through Dasatinib Plus Quercetin or Rapamycin Alleviates D-Galactose-Induced Cataract Progression

Journal of Functional Biomaterials, 2022
Senescent cells accumulate in aged organisms and promote the progression of age-related diseases including cataracts. Therefore, we aimed to study the therapeutic effects of senescence-targeting drugs on cataracts.
Yinhao Wang, Yulin Tseng, Keyu Chen, Xinglin Wang, Zebin Mao, Xuemin Li   +5 more
doaj   +1 more source

Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity. [PDF]

, 2020
Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer ...
Rovira, Miguel, Martins, Carla P., Miguel Rovira, Fruk, Ljiljana, González-Gualda, Estela, Félix Sancenón, Sancenón Galarza, Félix, Manuel Serrano, Lozano-Torres, Beatriz, Martínez-Máñez, Ramón, González-López, Cristina, Juan F. Blandez, Pàez-Rives, Marta, Macias, David, Serrano, Manuel, Joseph R. Wilson, Gary J. Doherty, Carla P. Martins, Marta Pàez‐Ribes, Doherty, Gary J., Zhenguang Zhang, Araceli Lérida‐Viso, Estela González‐Gualda, Beatriz Lozano‐Torres, Ljiljana Fruk, Wilson III, Joseph R., Lérida-Viso, Araceli, Daniel Muñoz‐Espín, Cristina González‐López, Sofía Mirón‐Barroso, Blandez, Juan F., MIrón-Barroso, Sofía, David Macias, Andrea Bernardos, Bernardos Bau, Andrea, Zhang, Zhenguang, Ramón Martínez‐Máñez, Hui‐Ling Ou, Ou, Hui-Ling, Muñoz-Espín, Daniel   +39 more
core   +4 more sources

Galactose‐modified duocarmycin prodrugs as senolytics [PDF]

Aging Cell, 2019
Abstract Senescence is a stable growth arrest that impairs the replication of damaged, old or preneoplastic cells, therefore contributing to tissue homeostasis. Senescent cells accumulate during ageing and are associated with cancer, fibrosis and many age‐related pathologies.
Guerrero, Ana, Guiho, Romain, Herranz, Nicolás, Uren, Anthony, Withers, Dominic J., Martínez-Barbera, Juan Pedro, Tietze, Lutz F., Gil, Jesús   +7 more
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Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

POLY-Senolytic nanoplatform for tumor-specific eradication of senescent tumor cells and mitigation of radiotherapy-induced immune resistance of cancer

Nature Communications
Radiotherapy (RT) efficacy is limited by RT-induced immune resistance. Here we show that RT upregulates programmed death ligand 1 (PD-L1) on senescent tumor cells (STCs) via bromodomain-containing protein 4 (BRD4) signaling, thereby promoting immune ...
Yi Lai, Shunan Zhang, Jiaxing Pan, Wenyue Lan, Min Li, Zifan Zhu, Leiming Xu, Bruno G. De Geest, Twan Lammers, Wen Zhang, Haijun Yu, Zhiai Xu   +11 more
doaj   +1 more source

Fibrillarin Resists Cellular Senescence Via SIRT1‐Dependent Nicotinamide Metabolism and Its Inhibition Sensitizes Senolytic Therapy in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
FBL directly binds to and stabilizes SIRT1 by blocking its ubiquitin‐proteasome degradation, thereby sustaining nicotinamide metabolism and redox homeostasis to counteract cellular senescence in ESCC. Genetic and pharmacological suppression of FBL sensitizes tumor cells to senolytic therapy.
Xing Jin, Hong Liu, Ling Gao, Lei Liu, Ji‐Bin Liu, Xiaoxia Jin, Ming‐Song Wang, Dan Liu, Li Feng, Wen‐Lian Chen   +9 more
wiley   +1 more source

Is exercise a senolytic medicine? A systematic review [PDF]

Aging Cell, 2020
AbstractCellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years ...
Xiang‐Ke Chen, Zhen‐Ni Yi, Gordon Tin‐Chun Wong, Kazi Md. Mahmudul Hasan, Joseph Shiu‐Kwong Kwan, Alvin Chun‐Hang Ma, Raymond Chuen‐Chung Chang   +6 more
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Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source