Results 41 to 50 of about 9,162 (237)
Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
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Ethical perspectives on advances in biogerontology [PDF]
, 2019 Worldwide populations are aging with economic development as a result of public health initiatives and advances in therapeutic discoveries. Since 1850, life expectancy has advanced by 1 year for every four.
Archard, David +8 more
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Senolytic therapies for healthy longevity [PDF]
Science, 2019 Clearing senescent cells with targeted drugs could combat age-associated ...
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Senescence explains age- and obesity-related liver steatosis
Cell Stress, 2017 Cellular senescence, the irreversible loss of replicative potential of somatic cells, was first described in fibroblasts cultured in vitro by Leonard Hayflick more than 50 years ago.
Mikolaj Ogrodnik, Diana Jurk
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Journal of Functional Biomaterials, 2022 Senescent cells accumulate in aged organisms and promote the progression of age-related diseases including cataracts. Therefore, we aimed to study the therapeutic effects of senescence-targeting drugs on cataracts.
Yinhao Wang +5 more
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Oxidation products of 5-methyl cytosine are decreased in senescent cells and tissues of progeroid mice [PDF]
, 2018 5-Hydroxymethylcytosine and 5-formylcytosine are stable DNA base modifications generated from 5-methylcytosine by the ten-eleven translocation protein family that function as epigenetic markers. 5-Hydroxymethyluracil may also be generated from thymine by
Czerwińska, Jolanta +12 more
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Is Senolytic Therapy in Cardiovascular Diseases Ready for Translation to Clinics?
BiomoleculesAging is a predominant risk factor for cardiovascular diseases. There is evidence demonstrating that senescent cells not only play a significant role in organism aging but also contribute to the pathogenesis of cardiovascular diseases in younger ages ...
Zhihong Yang +2 more
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Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window [PDF]
, 2020 During the implantation window, the endometrium becomes poised to transition to a pregnant state, a process driven by differentiation of stromal cells into decidual cells (DC).
Brighton, Paul (Paul J.) +12 more
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NAD+, Senolytics, or Pyruvate for Healthy Aging? [PDF]
Nutrition and Metabolic Insights, 2021 In last decades, healthy aging has become one of research hotspots in life science. It is well known that the nicotinamide adenine dinucleotide oxidized form (NAD+) level in cells decreases with aging and aging-related diseases. Several years ago, one of NAD+ precursors was first demonstrated with its new role in DNA damage repairing in mice ...
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Therapeutic Potential of Senolytics in Cardiovascular Disease [PDF]
Cardiovascular Drugs and Therapy, 2020 AbstractAgeing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the leading cause of death in 40% of individuals over 65 years old. Ageing is associated with both an increased prevalence of cardiovascular disease including heart failure, coronary artery disease, and myocardial infarction.
Emily Dookun +3 more
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