Results 61 to 70 of about 9,248 (241)

Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Molecular Metabolism
Obesity is a major contributor to metabolic and cardiovascular disease. Although senescent cells have been shown to accumulate in adipose tissue, the role of senescence in obesity-induced metabolic disorders and in cardiac dysfunction is not yet clear ...
Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz   +10 more
doaj   +1 more source

Senopathies—Diseases Associated with Cellular Senescence

Biomolecules, 2023
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak, Markus Schosserer, Johannes Grillari   +2 more
doaj   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Senescent cells: New target for an old treatment?

Molecular & Cellular Oncology, 2017
Many genotoxic chemotherapies have debilitating side effects and induce cellular senescence in normal tissues. Senescent cells acquire a pro-inflammatory phenotype which contributes to local and systemic inflammation.
Marco Demaria
doaj   +1 more source

Short senolytic or senostatic interventions rescue progression of radiation-induced frailty and premature ageing in mice

eLife, 2022
Cancer survivors suffer from progressive frailty, multimorbidity, and premature morbidity. We hypothesise that therapy-induced senescence and senescence progression via bystander effects are significant causes of this premature ageing phenotype ...
Edward Fielder, Tengfei Wan, Ghazaleh Alimohammadiha, Abbas Ishaq, Evon Low, B Melanie Weigand, George Kelly, Craig Parker, Brigid Griffin, Diana Jurk, Viktor I Korolchuk, Thomas von Zglinicki, Satomi Miwa   +12 more
doaj   +1 more source

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, EarlyView.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy

Cells, 2020
Here, we provide an overview of the importance of cellular fate in cancer as a group of diseases of abnormal cell growth. Tumor development and progression is a highly dynamic process, with several phases of evolution.
Francisco Triana-Martínez, María Isabel Loza, Eduardo Domínguez   +2 more
doaj   +1 more source

Dietary Curcumin Attenuates Hepatic Cellular Senescence by Suppressing the MAPK/NF-κB Signaling Pathway in Aged Mice

Antioxidants, 2023
Dietary interventions with bioactive compounds have been found to suppress the accumulation of senescent cells and senescence-associated secretory phenotypes (SASPs).
Da-Yeon Lee, Su-Jeong Lee, Prabha Chandrasekaran, Gopal Lamichhane, Jennifer F. O’Connell, Josephine M. Egan, Yoo Kim   +6 more
doaj   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Senolytic therapies for healthy longevity [PDF]

Science, 2019
Clearing senescent cells with targeted drugs could combat age-associated ...
openaire   +2 more sources