Results 71 to 80 of about 9,162 (237)

DNA damage: A main determinant of vascular aging [PDF]

, 2016
Vascular aging plays a central role in health problems and mortality in older people. Apart from the impact of several classical cardiovascular risk factors on the vasculature, chronological aging remains the single most important determinant of ...
Bautista-Niño, P.K. (Paula), Danser, A.H.J. (Jan), Portilla-Fernandez, E. (Eliana), Roks, A.J.M. (Anton), Vaughan, D.E. (Douglas E.)   +4 more
core   +2 more sources

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach

Frontiers in Immunology
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disorder of the central nervous system (CNS). Age is the strongest predictor of disease phenotype, with the majority of older adults transitioning to a progressive form marked by ...
Jeffrey Atkinson, Jeffrey Atkinson, Amy Dokiburra, Hayley Groover, Hayley Groover, Jonathan P. Godbout, Jonathan P. Godbout, Benjamin M. Segal, Benjamin M. Segal, Yinan Zhang   +9 more
doaj   +1 more source

The role of cellular senescence in metabolic diseases and the potential for senotherapeutic interventions

Frontiers in Cell and Developmental Biology, 2023
Cellular senescence represents an irreversible state of cell cycle arrest induced by various stimuli strongly associated with aging and several chronic ailments.
Huantong Zhang, Han Zhou, Xin Shen, Xingchen Lin, Yuke Zhang, Yiyi Sun, Yi Zhou, Lei Zhang, Lei Zhang, Dayong Zhang   +9 more
doaj   +1 more source

Cellular Senescence as the Causal Nexus of Aging [PDF]

, 2016
In this paper we present cellular senescence as the ultimate driver of the aging process, as a “causal nexus” that bridges microscopic subcellular damage with the phenotypic, macroscopic effect of aging.
Antonei B. Csoka, Evgeny O. Makarev, Naina Bhatia-Dey, Riya R. Kanherkar, Susan E. Stair   +4 more
core   +1 more source

New Trends in Aging Drug Discovery [PDF]

, 2022
Aging is considered the main risk factor for many chronic diseases that frequently appear at advanced ages. However, the inevitability of this process is being questioned by recent research that suggests that senescent cells have specific features that ...
Benhamú Salama, Bellinda, López Rodríguez, María Luz, Martín Fontecha, María del Mar, Ortega Gutiérrez, Silvia, Vázquez Villa, Henar   +4 more
core   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Senopathies—Diseases Associated with Cellular Senescence

Biomolecules, 2023
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak, Markus Schosserer, Johannes Grillari   +2 more
doaj   +1 more source

Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium [PDF]

, 2017
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs ...
Acosta, Aird, Al-Sabbagh, Barros, Bradford, Childs, Chowdhury, de Keizer, de Ziegler, Demidenko, Diep, Dimri, Drury, Erlebacher, Evans, Funayama, Gellersen, Groll, Hanna, Hapangama, Iannello, Krizhanovsky, Laws, Lucas, Lucas, Marçais, Matjusaitis, Mosteiro, Murakami, Muñoz-Espín, Paria, Park, Pfaffl, Pohnke, Rajagopalan, Ritschka, Ruifrok, Sadaie, Saeed, Sagiv, Sagiv, Salker, Smith, Takano, Team, van Deursen, Venables, Xiong, Yuan, Zhang, Zhu, Zhu   +51 more
core   +2 more sources

Targeted senotherapy improves electrographic and behavioral outcomes in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Current pharmacotherapy for temporal lobe epilepsy (TLE) is limited to symptomatic treatment and leaves approximately one third of patients with inadequate seizure control. Discovering disease‐modifying targets is an unmet clinical need. We have previously identified senescent cells (SCs) as one such target. Many drugs that eliminate
David J. McFall, Abbas I. Hussain, Michelle Cho, Patrick A. Forcelli   +3 more
wiley   +1 more source