Results 71 to 80 of about 2,081 (185)
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan +2 more
wiley +1 more source
Senolytic Drugs are Potential Skin Lightening Agent for Aging Pigmentation
, 2021 학위논문(석사)--아주대학교 일반대학원 :의생명과학과,2021. 2피부의 노화 과정은 색소 체계를 변형시키는 중요한 외적 요인이다. 세포 노화가 근본적인 노화 메커니즘이다. 노화 섬유아세포들이 노화 관련 색소 침착 부위에 축적되고 노화 중에 간질 상피 상호 작용을 통해 멜라닌세포 분화를 변화시킨다. 세놀리틱스 약물은 노화성에서는 세포 사멸을 유발할 수 있지만 비노화성 세포에서는 그렇지 않다.
박지희
core
Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products
, 2021 Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested in experimental models that the elimination of senescent cells with pharmacological ...
Oscar Salvador Barrera-Vázquez +2 more
core +1 more source
Journal of Clinical InvestigationThere is intense interest in identifying compounds that selectively kill senescent cells, termed senolytics, for ameliorating age-related comorbidities. However, screening for senolytic compounds currently relies on primary cells or cell lines where senescence is induced in vitro.
openaire +2 more sources
The Journal of Dermatology, EarlyView.ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba +6 more
wiley +1 more source
DEVELOPMENT OF SENOLYTIC THERAPIES FOR TREATMENT OF AGEING RELATED DISORDERS
, 2022 Aging is a complex biological process signified by a decline in physiological functions and increased disease susceptibility. Among its various defining features, cellular senescence stands out as a significant hallmark.
SHARIFI, SAMAN
core
Understanding the Type 2 Immunity: An Evolving View Beyond Allergic Diseases
Allergy, EarlyView.ABSTRACT Type 2 (T2) immunity is classically associated with defense against helminths and environmental threats, from a physiological perspective, and with allergies and eosinophilic inflammatory diseases, in a pathological sense. However, growing evidence reveals that T2 pathways also support other essential homeostatic functions, including tissue ...
Rodrigo Jiménez‐Saiz +22 more
wiley +1 more source
Targeting Mitochondrial Integrity as a New Senolytic Strategy
Aging, characterized by accumulation of senescent cells, is a driving factor of various age-related diseases. These conditions pose significant health risks globally due to their increasing prevalence and serious complications.
Bohacova, Klara +10 more
core +1 more source
Targeting hexokinase 2 to induce breast cancer cell senescence
British Journal of Pharmacology, EarlyView.Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof +8 more
wiley +1 more source
Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach
Frontiers in ImmunologyMultiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disorder of the central nervous system (CNS). Age is the strongest predictor of disease phenotype, with the majority of older adults transitioning to a progressive form marked by ...
Jeffrey Atkinson +9 more
doaj +1 more source