Results 51 to 60 of about 9,162 (237)

Effect of Senolytic to alleviating Osteoporosis in Mice induced by Retinoic Acid [PDF]

E3S Web of Conferences, 2020
Senolytic is a potential new anti-aging drug, and it is worth exploring whether it has an inhibitory effect on osteoporosis. Osteoporosis models in mice were established by gavage of retinoic acid(RA), and Senolytic drugs (dasatinib and quercetin) were ...
Liu Jia, Xiao Yazhe, Xie Jing, He Lian
doaj   +1 more source

Senolytics in the treatment of diabetic retinopathy

Frontiers in Pharmacology, 2022
Diabetic retinopathy (DR) is the most common complication of diabetes. DR is characterized by damage to retinal vasculature resulting in vision impairment and, if untreated, could eventually lead to blindness. The pathogenic mechanism of DR is complex; emerging studies suggest that premature senescence of retinal cells and subsequent secretion of ...
Hassan, Jannah Waled, Bhatwadekar, Ashay D.   +1 more
openaire   +4 more sources

Senescent cell depletion alleviates obesity-related metabolic and cardiac disorders

Molecular Metabolism
Obesity is a major contributor to metabolic and cardiovascular disease. Although senescent cells have been shown to accumulate in adipose tissue, the role of senescence in obesity-induced metabolic disorders and in cardiac dysfunction is not yet clear ...
Tábatha de Oliveira Silva, Guilherme Lunardon, Caroline A. Lino, Amanda de Almeida Silva, Shiju Zhang, Maria Cláudia Costa Irigoyen, Yao Wei Lu, John D. Mably, Maria Luiza M. Barreto-Chaves, Da-Zhi Wang, Gabriela P. Diniz   +10 more
doaj   +1 more source

The Senolytic Drug Navitoclax (ABT-263) Causes Trabecular Bone Loss and Impaired Osteoprogenitor Function in Aged Mice

Frontiers in Cell and Developmental Biology, 2020
Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but chronic senescence, as in aging, can contribute to the development of age-related tissue dysfunction and disease.
Anuj K. Sharma, Rachel L. Roberts, Reginald D. Benson, Jessica L. Pierce, Kanglun Yu, Mark W. Hamrick, Meghan E. McGee-Lawrence, Meghan E. McGee-Lawrence   +7 more
doaj   +1 more source

Doxycycline, Azithromycin and vitamin C (DAV) : a potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs) [PDF]

, 2019
Here, we devised a new strategy for eradicating cancer stem cells (CSCs), via a "synthetic-metabolic" approach, involving two FDA-approved antibiotics and a dietary vitamin supplement.
Cantoni, Cantoni, Fiorani, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Lisanti, Naccarato, Rebouche, Rivas, Saha, Sotgia, Sotgia, Sotgia, Sotgia, Tonazzi, van Zanten, Zhang   +31 more
core   +1 more source

A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]

, 2020
The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan, Campisi, Judith, Ferrucci, Luigi, Holtz, Anja, Jeon, Ok Hee, Kale, Abhijit, Kuehnemann, Chisaka, Payne, Therese, Rao, Chirag, Schilling, Birgit, Shah, Samah, Sharma, Vagisha   +11 more
core   +1 more source

Ionizing Radiation-Induced Cellular Senescence in Normal, Non-transformed Cells and the Involved DNA Damage Response: A Mini Review

Frontiers in Pharmacology, 2018
Cellular senescence is identified by a living cell in irreversible and persistent cell cycle arrest in response to various cellular stresses. Senescent cells secrete senescence-associated secretory phenotype factors that can amplify cellular senescence ...
Mengqian Li, Liting You, Jianxin Xue, You Lu   +3 more
doaj   +1 more source

A novel suicide gene therapy for the treatment of p16-overexpressing tumors [PDF]

, 2017
p16Ink4ais a potent cell cycle inhibitor engaged to support cell cycle arrest during cellular senescence. However, in tumors carrying mutations in key downstream effectors, p16Ink4ais highly expressed but fails to block cell proliferation.
Campisi, Judith, Demaria, Marco, Kohli, Jaskaren   +2 more
core   +2 more sources

The Clinical Potential of Senolytic Drugs [PDF]

Journal of the American Geriatrics Society, 2017
Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic ...
James L, Kirkland, Tamara, Tchkonia, Yi, Zhu, Laura J, Niedernhofer, Paul D, Robbins   +4 more
openaire   +2 more sources

PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation [PDF]

, 2018
Telomeric crisis is the final replicative barrier to cell immortalisation; it is characterised by genome instability and cell death and is triggered when telomeres become critically short and are subjected to fusion. Pre-cancerous lesions, or early stage
Argani, Ashworth, Ashworth, Bacchetti, Bacchetti, Bai, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Baird, Bao, Burkle, Chang, Curtin, Dahm-Daphi, Dantzer, Dantzer, Dantzer, de Bono, de Lange, de Lange, de Lange, de Lange, De Marzo, DePinho, DePinho, Fegan, Fegan, Helleday, Helleday, Hendrickson, Iliakis, Jackson, Jackson, Karlseder, Lehtio, Lieber, Liu, Moroni, Ouellette, Pellat-Deceunynck, Pellicciari, Piwnica-Worms, Pommier, Pommier, Reddel, Robbins, Rottenberg, Salzer, Schuler, Schuler, Sfeir, Smith, Sugano, Weinberg, Wynford-Thomas, Zupi   +60 more
core   +3 more sources