Results 81 to 90 of about 2,081 (185)
Journal of Internal Medicine, EarlyView.Abstract Population ageing is portrayed as a threat to the sustainability of health and welfare systems. This narrative—grounded in static chronological definitions of old age—risks overstating the burden of increasing longevity while overlooking changes in survival, health and population composition. In this article, we adopt a demographic perspective
Daniele Vignoli +7 more
wiley +1 more source
Cross-senolytic effects of dasatinib and quercetin in humans
, 2023 Introduction: Senescent cells are toxic cells. Their number increases every day and after some time it leads to the appearance of signs of aging. Senescent cells cause age-related pathologies.
Tkemaladze, Jaba, Jaba Tkemaladze
core +1 more source
LifeThis study investigated the effects of chelidonic acid (CA) on hydrogen peroxide (H2O2) induced cellular senescence in human skin fibroblast cells (BJ).
Burcu Turkoglu, Banu Mansuroglu
doaj +1 more source
Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases
Journal of Periodontal Research, EarlyView.This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini +3 more
wiley +1 more source
Frontiers in MedicineIntroductionChronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, with increased numbers of senescent cells found within the COPD Lung.
Jonathan R. Baker +6 more
doaj +1 more source
Orthopaedic Surgery, EarlyView.This article outlines a paradigm shift in OA therapeutics, OA as a systemic disease of joint microenvironment imbalance. It synthesizes advances in targeting key pathological hubs—immune, metabolic, and senescent—and details novel regenerative strategies using engineered biomaterials and exosomes.
Yongbiao Meng, Shenghua Wu, Quanchun Liu
wiley +1 more source
Periodontology 2000, EarlyView.Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi +4 more
wiley +1 more source
Cellular senescence and senolytic therapy in traumatic brain injury
Frontiers in NeuroscienceTraumatic brain injury (TBI) is a major cause of death and long-term disability in the United States. The initial primary injury in TBI is followed by a secondary injury cascade of molecular events, which can persist for years, and contributes to ...
Darrell W. Brann +5 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties
The accumulation of senescent cells contributes to aging and related diseases; therefore, discovering safe senolytic agents-compounds that selectively eliminate senescent cells-is a critical priority.
Giordani, Chiara +24 more
core +1 more source