Results 101 to 110 of about 9,248 (241)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro‐anabolic mediators

bioRxiv
Cellular senescence is associated with various age-related disorders and is assumed to play a major role in the pathogenesis of osteoarthritis (OA). Based on this, we tested a senolytic combination therapy using Dasatinib (D) and Quercetin (Q) on aged ...
Svenja Maurer, Valeria Kirsch, L. Ruths, Rolf E. Brenner, J. Riegger   +4 more
semanticscholar   +1 more source

Bioresorbable Scaffolds for Coronary Arteries: Where Do We Stand Today?

VIEW Medicine, Volume 1, Issue 1, August 2026.
Bioresorbable coronary scaffolds are moving from thick strut pitfalls to thinner, stronger, healing‐oriented designs. Integrating advances in materials, guided implantation with preparation, size, and postdilation steps, and resorption aligned to healing, we synthesize clinical evidence and chart a roadmap toward intelligent, transient platforms ...
Junya Matsuda, Tatsuya Watanabe, Satoshi Yuhara, John M. Kelly, Hirotsugu Kurobe, Toshiharu Shinoka   +5 more
wiley   +1 more source

Senolytic effects of a modified Gingerenone A

npj Aging
Abstract Senescent cells accumulate with aging and are associated with several age-associated diseases and functional declines. Eliminating senescent cells with senolytics improves aging phenotypes in mouse models and may improve the health of people with chronic diseases.
Moaddel, Ruin, Sanehira, Chad, Keyes, Gregory, Cui, Chang-Yi, Ahmadkhaniha, Reza, Candia, Julián, Price, Nathan L., Eckroth, Sarah, Middleton, Bryce, Khadeer, Mohammed, Mazucanti, Caio H., McDevitt, Ross A., Gorospe, Myriam, de Cabo, Rafael, Egan, Josephine M., Ramsden, Christopher E., Ferrucci, Luigi   +16 more
openaire   +2 more sources

An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis

Journal of Clinical Investigation
The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues, termed senolytics. However, a major caveat with current senolytic screens is the use of cell lines as targets where
Jin Young Lee, Nabora S. Reyes, Supriya Ravishankar, Minqi Zhou, M. Krasilnikov, Christian Ringler, Grace Pohan, Chris Wilson, K. Ang, P. Wolters, T. Tsukui, D. Sheppard, M. Arkin, Tien Peng   +13 more
semanticscholar   +1 more source

Neurocognitive Aging Following Acute Illness: Pathobiology and a Framework for Developing Neurotherapeutic Agents

Brain and Behavior, Volume 16, Issue 6, June 2026.
In this review, we discuss the scientific basis for how neurocognitive aging occurs after critical illness, including sepsis, trauma, and burns, and the clinical need to develop therapies to reduce inflammation, protect the blood–brain barrier, remove senescent cells, and enhance neuroplasticity.
Errin Lawrence, Daniel Fulton, Poppy Brown, Subashini Suresh, Mark Morris, Paraskevi Goggolidou, Sree Chaithanya, Marcus Abbawy, Amelia Wild, Prashant Nasa, Niharika A. Duggal, Fang Gao‐Smith, Zubair Ahmed, Suresh Renukappa, Tonny Veenith   +14 more
wiley   +1 more source

Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR

Current Issues in Molecular Biology
Cellular senescence plays a crucial role in skin aging, with senescent dermal fibroblasts contributing to reduced skin elasticity and increased inflammation.
Harald Kühnel, Markus Seiler, Barbara Feldhofer, Atefeh Ebrahimian, Michael Maurer   +4 more
doaj   +1 more source

Solanesol Alleviates Perfluoroheptanoic Acid‐Induced Premature Senescence in Human Skin Fibroblasts via RNA Methylation

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Perfluoroheptanoic acid (PFHpA) induces premature senescence in normal human skin fibroblasts (HSFs), as characterized by decreased cell viability, increased SA‐β‐gal staining, impaired wound healing, cell cycle dysregulation, elevated ROS levels, and upregulated SASP mRNA expression.
Jiaqi Fu, Tingting Huang, Guisong Li, Xinyu Zhang, Luyi Tan, Chenyu Zhu, Wenji Zhang, Wenjuan Zhang   +7 more
wiley   +1 more source

A novel senolytic drug for pulmonary fibrosis: BTSA1 targets apoptosis of senescent myofibroblasts by activating BAX

Aging Cell
Idiopathic pulmonary fibrosis is a progressive and age‐related disease that results from impaired lung repair following injury. Targeting senescent myofibroblasts with senolytic drugs attenuates pulmonary fibrosis, revealing a detrimental role of these ...
Mengxia Shen, Jia-feng Fu, Yun-na Zhang, Yanfen Chang, Xiao-hong Li, Haipeng Cheng, Yujia Qiu, Min Shao, Yang Han, Yanyan Zhou, Zi-qiang Luo   +10 more
semanticscholar   +1 more source