Results 101 to 110 of about 9,162 (237)

Sex, senescence, senolytics, and cognition

Frontiers in Aging Neuroscience
This review focuses on sexual dimorphism in cellular senescence and senolytic treatment in relation to brain health and age-related cognitive decline. The stressors of aging, DNA damage, inflammation, and oxidative stress induce cell senescence, a hallmark of aging.
Thomas C. Foster, Thomas C. Foster, Ashok Kumar   +2 more
openaire   +3 more sources

Spontaneous DNA damage to the nuclear genome promotes senescence,redox imbalance and aging [PDF]

, 2018
Accumulation of senescent cells over time contributes to aging and age-related diseases. However, what drives senescence in vivo is not clear. Here we used a genetic approach to determine if spontaneous nuclear DNA damage is sufficient to initiate ...
Bell-Temin, Harris, Burd, Christin E., Cantu-Medellin, Nadiezhda, Cifuentes-Pagano, Eugenia, Czerwińska, Jolanta, Feldman, Chelsea H., Frantz, Marie-Céline, Fuhrmann-Stroissnigg, Heike, Gregg, Siobhán Q., Gurkar, Aditi U., Harris, Jamie B., Johnson, Caroline H., Kelley, Eric E., LaRusso, Nicholas F., Li, Xuesen, M. St. Croix, Claudette, Maniar, Salony, McGowan, Sara J., Nasto, Luigi A., Niedernhofer, Laura J., Opresko, Patricia L., Pagano, Patrick J., Pope-Varsalona, Hannah, Rigatti, Lora H., Robbins, Paul D., Robinson, Andria R., Robinson, Renã A.S., Ross, Mark A., Rozgaja, Tania A., Siuzdak, Gary, Skoda, Erin M., Stolz, Donna B., Tilstra, Jeremy S., Trussoni, Christy E., Tudek, Barbara, Vo, Nam V., Wang, Jin, Wang, Yinsheng, Watkins, Simon C., Wipf, Peter, Yates, Nathan A., Yousefzadeh, Matt J.   +41 more
core   +3 more sources

Reviewing the benefits and clinical outcomes of oral fibroblasts over mesenchymal stem cells for repairing periodontal defects during or after orthodontic tooth movement

Periodontology 2000, EarlyView.
Abstract Orthodontic therapy applies forces to teeth, causing an inflammatory reaction in the periodontal ligament. This is repaired by remodeling of the periodontium, allowing tooth displacement. Although orthodontic therapy is mostly initiated during childhood and adolescence, the number of adults seeking this treatment is increasing as our society's
Ludovica Parisi, Eleni Mavrogonatou, Anton Sculean, Dimitris Kletsas, Martin Degen   +4 more
wiley   +1 more source

Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay. [PDF]

, 2016
Cellular senescence is a stable cell cycle arrest that is the causative process of aging. The PI3K/AKT/mTOR pathway is implicated in the control of cellular senescence and inhibitors of this pathway have been successfully used for life span prolongation ...
Alimonti, A., Bisio, A., Brun, P., Chen, J., Cocetta, V., Dall'Acqua, S., Mancino, G., Matic, I., Mattei, M., Milanese, M., Montopoli, M., Revandkar, A.   +11 more
core   +2 more sources

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Senolytic treatment alleviates doxorubicin‐induced chemobrain

Aging Cell
AbstractDoxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced cognitive impairments (chemobrain). Chemobrain is associated with inflammation and oxidative stress similar to aging. As such, Dox treatment has also been used as a model of aging.
Vivekananda Budamagunta, Ashok Kumar, Asha Rani, Sahana Manohar Sindhu, Yang Yang, Daohong Zhou, Thomas C. Foster   +6 more
openaire   +2 more sources

Targeting Cellular Senescence to Enhance Human Endometrial Stromal Cell Decidualization and Inhibit Their Migration

Biomolecules
Cellular senescence leads to stable cell cycle arrest and an inflammatory senescence-associated secretory phenotype that varies with stressor and cell type. To mitigate these effects and improve health, senotherapeutics (e.g., senolytics and senomorphics)
Julia Delenko, Nathaniel Hyman, Prodyot K. Chatterjee, Polona Safaric Tepes, Andrew J. Shih, Xiangying Xue, Jane Gurney, Andrew G. Baker, Cheng Wei, Daniel Munoz Espin, Ljiljana Fruk, Peter K. Gregersen, Christine N. Metz   +12 more
doaj   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, EarlyView.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source