Results 111 to 120 of about 9,248 (241)
Controversies Surrounding Critical‐Size Defects: Influence of Age and Biological Characteristics
Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 6, June 2026.ABSTRACT Critical‐size defects (CSDs) in craniofacial reconstruction refer to osseous gaps that fail to heal spontaneously, increasing the risk of neurological impairment and craniofacial dysmorphology. Despite decades of investigation, controversy still exists surrounding the definition of CSDs, with criteria varying across species, experimental ...
Andrew Nordlund +7 more
wiley +1 more source
Respirology, Volume 31, Issue 6, Page 561-577, June 2026.ABSTRACT Chronic obstructive pulmonary disease (COPD) remains the third leading cause of death worldwide, and conventional bronchodilator‐based therapies have limited efficacy in preventing exacerbations and disease progression. The 2024–2026 period represents a historic inflection point: three mechanistically distinct agents received Food and Drug ...
Naoya Fujino, Hisatoshi Sugiura
wiley +1 more source
Aging Cell, Volume 25, Issue 6, June 2026.This study illustrates that omega‐3 PUFAs with their receptor FFAR4 alleviate tubular senescence and fibrosis in aged and fibrotic kidneys. Furthermore, we indicate that tubular FFAR4 improves renal senescence via 15d‐PGJ2‐PPARγ‐Klotho signaling, and suppresses kidney fibrosis by senescent tubular cell‐driven fibroblast activation.
Letian Yang +9 more
wiley +1 more source
Senolytic treatment alleviates doxorubicin‐induced chemobrain
Aging CellDoxorubicin (Dox), a widely used treatment for cancer, can result in chemotherapy‐induced cognitive impairments (chemobrain). Chemobrain is associated with inflammation and oxidative stress similar to aging. As such, Dox treatment has also been used as a
Vivekananda Budamagunta +6 more
semanticscholar +1 more source
The Aging Microenvironment Shapes Angiogenic Remodeling in IBD‐Associated Colorectal Carcinogenesis
Aging Cell, Volume 25, Issue 6, June 2026.In IBD, chronic inflammation promotes cellular senescence across epithelial, stromal, endothelial, and immune compartments. The resulting SASP drives pathological angiogenesis, vascular dysfunction, hypoxia, and immune suppression, thereby facilitating progression from inflammation to dysplasia and colitis‐associated colorectal cancer.
Ruoshu Duan +4 more
wiley +1 more source
Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies
CellsCellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as the senescence-associated secretory phenotype (SASP), causing chronic inflammation; at the ...
Shuaiqi Wang +6 more
doaj +1 more source
Aging and DiseaseCellular senescence is characterized by the permanent arrest of cell proliferation and is a response to endogenous and exogenous stress. The continuous accumulation of senescent cells (SnCs) in the body leads to the development of aging and age-related ...
Liyao Zheng +5 more
semanticscholar +1 more source
PharmaceuticalsBackground: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova +4 more
doaj +1 more source
The Clinical Respiratory Journal, Volume 20, Issue 6, June 2026.Basal cells are expanded within the small airway epithelium in IPF. This change is associated with the severity of fibrosis and may participate in disease pathogenesis via SP1‐mediated senescence‐associated secretory phenotype (SASP). ABSTRACT Idiopathic pulmonary fibrosis is a progressive interstitial lung disease with limited treatment options and ...
Xiaoyan Wang +5 more
wiley +1 more source
Targeting anxiety and senescence with senolytics
Aging, 2022 Raffaele, Marco, Vinciguerra, Manlio
openaire +2 more sources