Results 111 to 120 of about 2,081 (185)
JOR SPINE, Volume 9, Issue 3, September 2026.We investigated whether transgenic conversion of omega‐6 to omega‐3 fatty acids mitigates obesity‐associated intervertebral disc (IVD) degeneration. Using fat‐1 mice on a high‐fat diet, we observed that endogenous omega‐3 production prevented diet‐induced disc pathology, metabolic dysfunction, and reduced systemic inflammation, indicating a protective ...
Shirley N. Tang +8 more
wiley +1 more source
JOR SPINE, Volume 9, Issue 3, September 2026.ABSTRACTBackgroundLow back pain remains the leading cause of disability worldwide, with intervertebral disc degeneration representing a major biological contributor. Although cell‐based therapies have shown promise in preclinical models, clinical translation has yielded modest and inconsistent outcomes.
Tynhinane Hamidouche +9 more
wiley +1 more source
Amino Acid Metabolism in Health and Disease
MedComm, Volume 7, Issue 9, September 2026.This graphical abstract delineates the multifaceted role of amino acid metabolism in health and disease. It illustrates how amino acids sustain physiological homeostasis across the liver, kidney, brain, heart, intestine, muscle, skeleton, and immune system.
Zhiwei Su +7 more
wiley +1 more source
Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis
Portal Hypertension &Cirrhosis, Volume 5, Issue 3, Page 241-259, September 2026.Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao +4 more
wiley +1 more source
Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies
CellsCellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as the senescence-associated secretory phenotype (SASP), causing chronic inflammation; at the ...
Shuaiqi Wang +6 more
doaj +1 more source
Aging Cell, Volume 25, Issue 9, September 2026.The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li +4 more
wiley +1 more source
PharmaceuticalsBackground: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova +4 more
doaj +1 more source
Aging Cell, Volume 25, Issue 9, September 2026.Transcriptomic analysis using a rabbit glaucoma filtration surgery model, combined with in vitro experiments on human conjunctival fibroblasts, demonstrates that mitomycin C induces a senescence‐associated secretory phenotype (SASP)‐like state. These SASP‐like fibroblasts were selectively eliminated by the specific senolytic agent, highlighting their ...
Akitoshi Kimura +12 more
wiley +1 more source
Editorial: Cellular senescence in physiology and pathophysiology
Frontiers in Physiology, 2023 Mustafa Ark, Mohammad Nasir Uddin
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Frontiers in NutritionCellular senescence has emerged as a key contributor to brain aging and neurodegenerative diseases, which are increasing in prevalence as life expectancy rises.
Verónica Salas-Venegas +5 more
doaj +1 more source