Results 131 to 140 of about 2,081 (185)

Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies

Senolytic and senomorphic therapies have gained more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the “normal” cells. Aging is not a disease.
Harald Kühnel, Zsolt Véghelyi, Michael Maurer, Monika Imb   +3 more
core   +1 more source

Low‐Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle‐Aged and Older Adults: Study Protocol for a Triple‐Blind, Randomised, Placebo‐Controlled Trial

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Systemic chronic inflammation contributes to the development of many age‐related chronic diseases and represents a promising target for interventions aiming at promoting healthy aging. Fisetin is a naturally occurring flavonoid with anti‐inflammatory, antioxidant and senolytic effects in vitro and in animal models, but evidence from randomised
Juliette Tavenier, Magnus Berglind, Line Fleischer Hach, Louise Westberg Strejby Christensen, Maria Jana Masarikova, Rafal Yahya, Mette Bendtz Lindstrøm, Baker Nawfal Jawad, Anna Zatkova, Rikke Lundsgaard Nielsen, Helle Gybel Juul‐Larsen, Thomas Kallemose, Jan Olof Nehlin, Morten Baltzer Houlind, Ove Andersen, Line Jee Hartmann Rasmussen   +15 more
wiley   +1 more source

Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults—A Narrative Review

Orthopaedic Surgery, Volume 18, Issue 9, Page 1785-1803, September 2026.
This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu, Fan Xu, Maoqiang Fan, Yao Liu, Zhe Song   +4 more
wiley   +1 more source

Treating age‐related loss of muscle mass and function: Where should we be focusing?

The Journal of Physiology, Volume 604, Issue 17, Page 7059-7075, 1 September 2026.
Abstract figure legend Perturbations contributing to the age‐related loss of muscle mass and strength. A, in the spinal cord, self‐reinforcing cycles of oxidative stress, mitochondrial dysfunction and inflammation mediated by cells, including microglia, contribute to motor neuron degeneration.
Daniel J. Ham, Christopher S. Fry, Avnika Ashok Ruparelia, Shyuan T. Ngo, Séverine Lamon   +4 more
wiley   +1 more source

The dual role of cellular senescence in human tumor progression and therapy

MedComm
Cellular senescence, one of the hallmarks of cancer, is characterized by cell cycle arrest and the loss of most normal cellular functions while acquiring a hypersecretory, proinflammatory phenotype.
Liang Ma, Jie Yu, Yidian Fu, Xiaoyu He, Shengfang Ge, Renbing Jia, Ai Zhuang, Zhi Yang, Xianqun Fan   +8 more
doaj   +1 more source

Comparative Phytochemical Profiling and Phenotypic Senolytic Screening of Botanical Extracts for Oxidative-Stress-Induced Skin-Cell Senescence

Cellular senescence contributes to skin aging through the accumulation of senescent cells and the secretion of senescence-associated secretory phenotype (SASP) factors.
Jin Woo Min, Hyeontae Kang, Hee Cheol Kang, Kyoung-Min Choi, Somi Park, Ji Eun Lee   +5 more
core   +1 more source

Paradoxes of senolytics

Aging, 2018
openaire   +2 more sources

Senolytic CAR T cells [PDF]

Nature Medicine, 2020
openaire   +2 more sources

Senolytic properties of DR5-selective TRAIL in pancreatic cancer cell lines

Pancreatic adenocarcinoma is one of the most aggressive cancers. Its treatment relies on conventional chemotherapy agents; particularly gemcitabine. Chemotherapy is known to induce cell cycle arrest and the development of a senescent phenotype in tumor ...
M. P. Kirpichnikov, M. E. Gasparian, A. V. Yagolovich, D. V. Mazur, D. A. Dolgikh, N. V. Antipova, A. A. Isakova, E. I. Ivanova   +7 more
core   +1 more source

Senolytic Targeting of Anti-Apoptotic Bcl Family Increases Cell Death in UV-Irradiated Senescent Melanocytes: Search for Senolytics

Senescent melanocytes have been suggested to play a role in the development of ageing-associated pigmentary changes and skin ageing. Here, we assessed the senolytic capacity of recognised senolytic chemicals and natural compounds in UV-irradiated ...
Kim, Y, Baek, DJ, Kim, JC, Kim, NY, Kang, HY, Park, TJ   +5 more
core   +1 more source