Results 131 to 140 of about 9,162 (237)

Recent Advances in Aging and Immunosenescence: Mechanisms and Therapeutic Strategies

Cells
Cellular senescence is an irreversible state of cell cycle arrest. Senescent cells (SCs) accumulate in the body with age and secrete harmful substances known as the senescence-associated secretory phenotype (SASP), causing chronic inflammation; at the ...
Shuaiqi Wang, Tong Huo, Mingyang Lu, Yueqi Zhao, Jianmin Zhang, Wei He, Hui Chen   +6 more
doaj   +1 more source

The Potential of Polyphenols in Modulating the Cellular Senescence Process: Implications and Mechanism of Action

Pharmaceuticals
Background: Cellular senescence is a biological process with a dual role in organismal health. While transient senescence supports tissue repair and acts as a tumor-suppressive mechanism, the chronic accumulation of senescent cells contributes to aging ...
Larissa Della Vedova, Giovanna Baron, Paolo Morazzoni, Giancarlo Aldini, Francesca Gado   +4 more
doaj   +1 more source

Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies [PDF]

A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely in their sensitivity ...
Alarcón Cor, Tomás, Bosch-Barrera, J, Cuyàs, Elisabet, Llop-Hernández, Àngela, Lupu, Ruth, López, Júlia, López-Bonet, Eugeni, Martin-Castillo, Begoña, Martínez Balibrea, Eva, Menendez, Javier A., Sardanyés, Josep, Serrano-Hervás, Eila, Teixidor, Eduard, Verdura, Sara   +13 more
core   +1 more source

Senolytic CAR T cells [PDF]

Nature Medicine, 2020
openaire   +2 more sources

Apoptotic vesicle-mediated senolytics requires mechanical loading

Theranostics
Rationale: Mechanical force plays crucial roles in extracellular vesicle biogenesis, release, composition and activity. However, it is unknown whether mechanical force regulates apoptotic vesicle (apoV) production. Methods: The effects of mechanical unloading on extracellular vesicles of bone marrow were evaluated through morphology, size distribution,
Xue, Zhulin, Jiang, Yexiang, Meng, Bowen, Lu, Lu, Hao, Meng, Zhang, Yi, Shi, Songtao, Li, Zili, Mao, Xueli   +8 more
openaire   +2 more sources

Influence of gut microbiota on atherosclerosis [PDF]

Cardiovascular diseases (CVD) are recognized as a leading cause of death globally. Atherosclerosis, a key component of many CVDs, is a condition where plaque material builds up inside the arteries, leading to their narrowing and altered blood flow ...
Yntema, Tessa
core   +2 more sources

c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors [PDF]

, 2017
Alspach, Elise, Arthur, Laura L, Flanagan, Kevin C, Parajuli, Shankar, Pazolli, Ermira, Ren, Qihao, Stewart, Sheila A, Tapia, Roberto   +7 more
core   +2 more sources

Targeting anxiety and senescence with senolytics

Aging, 2022
Raffaele, Marco, Vinciguerra, Manlio
openaire   +2 more sources

The dual role of cellular senescence in human tumor progression and therapy

MedComm
Cellular senescence, one of the hallmarks of cancer, is characterized by cell cycle arrest and the loss of most normal cellular functions while acquiring a hypersecretory, proinflammatory phenotype.
Liang Ma, Jie Yu, Yidian Fu, Xiaoyu He, Shengfang Ge, Renbing Jia, Ai Zhuang, Zhi Yang, Xianqun Fan   +8 more
doaj   +1 more source

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Clinical and Translational Medicine
Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong, Lu Dong, Qiongying Lv, Yutong Yin, Jiahui Zhao, Youning Ke, Shixuan Wang, Wei Zhang, Meng Wu   +8 more
doaj   +1 more source