Results 121 to 130 of about 2,081 (185)
Timing‐Dependent Clearance of p16‐Positive Cells Mitigates Radiation‐Induced Accelerated Aging
Aging Cell, Volume 25, Issue 9, September 2026.Genotoxic stress induces a progressive accelerated aging‐like phenotype driven by the delayed accumulation of p16Ink4a‐positive senescent cells. Selective clearance of these cells improves healthspan, tissue function, and survival only when initiated after senescent cells have accumulated, highlighting a critical therapeutic window for senescence ...
Karla Valdivieso +15 more
wiley +1 more source
Insights Into the Interplay Between the Senescent Cells and Immune Cells
Aging Cell, Volume 25, Issue 9, September 2026.Kidney aging is associated with increased proximal tubular senescence and leukocyte infiltration. Senolytic treatment reduces senescent cell burden and overall immune cell infiltration. However, macrophages remain enriched around residual senescent cells.
Martin Jaros +7 more
wiley +1 more source
Mitochondrial priming and response to BH3 mimetics in "one-two punch" senogenic-senolytic strategies [PDF]
A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely in their sensitivity ...
Sardanyés, Josep +13 more
core +1 more source
NAD+ Metabolic Reprogramming Drives CD8+ T Cells Senescence and Exacerbates Ulcerative Colitis
Aging Cell, Volume 25, Issue 9, September 2026.Nicotinamide adenine dinucleotide (NAD+) depletion induces mitochondrial dysfunction and cytosolic mtDNA leakage in CD8+ T cells, activating the cGAS‐STING pathway and promoting a senescence‐associated secretory phenotype (SASP). The resulting pro‐inflammatory CD8+ T cells release IFN‐γ and TNF‐α, disrupt the intestinal epithelial barrier, and ...
Maolin Ye +9 more
wiley +1 more source
Transmembrane Protein PTCHD4 Is a Novel Regulator of Cellular Senescence and Age‐Related Pathologies
Aging Cell, Volume 25, Issue 9, September 2026.PTCHD4 is induced by aging‐ and injury‐associated stresses and acts as a senescence‐associated transmembrane regulator. Through AKT activation, PTCHD4 promotes cellular senescence, SASP, functional decline, and pulmonary fibrosis, whereas PTCHD4 deficiency dampens AKT signaling and alleviates senescence‐associated pathological phenotypes.
Mingyue Wang +11 more
wiley +1 more source
Aging Cell, Volume 25, Issue 9, September 2026.Neuronal senescence‐like states arise from convergent intrinsic and disease‐associated stressors and are linked to persistent dysfunction, SASP‐like signaling, and altered glial interactions. Because no single marker is definitive in post‐mitotic neurons, multimarker and context‐dependent frameworks are required to define their role in ...
Miraj Ud Din Momand +2 more
wiley +1 more source
Senolytics, a category of drugs targeting aging processes, have garnered significant attention since their emergence in 2015. Unlike traditional drug development approaches that rely on randomized screening, research on aging-related pharmaceuticals has ...
Yaowen Ye +3 more
core +1 more source
Targeting anxiety and senescence with senolytics
Aging, 2022 Raffaele, Marco, Vinciguerra, Manlio
openaire +2 more sources
Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter +20 more
wiley +1 more source
Clinical Features of Cellular Senescence Pathways in Severe Asthma
Allergy, Volume 81, Issue 9, Page 3273-3285, September 2026.In bronchial biopsies, SASP and p53 pathway enrichment scores are elevated in severe asthma versus non‐severe asthma and healthy controls. SASP enrichment is validated in the independent NOVA cohort. SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status.
Woo‐Jung Song +122 more
wiley +1 more source