Results 121 to 130 of about 9,162 (237)

Defining melanoma combination therapies that provide senolytic sensitivity in human melanoma cells

Frontiers in Cell and Developmental Biology
Malignant Melanoma that resists immunotherapy remains the deadliest form of skin cancer owing to poor clinically lasting responses. Alternative like genotoxic or targeted chemotherapy trigger various cancer cell fates after treatment including cell death
Daméhan Tchelougou, Nicolas Malaquin, Guillaume B. Cardin, Jordan Desmul, Simon Turcotte, Simon Turcotte, Francis Rodier, Francis Rodier   +7 more
doaj   +1 more source

Senolytic treatment for low back pain

Science Advances
Senescent cells (SnCs) accumulate because of aging and external cellular stress throughout the body. They adopt a senescence-associated secretory phenotype (SASP) and release inflammatory and degenerative factors that actively contribute to age-related diseases, such as low back pain (LBP). The senolytics, o
Mannarino, Matthew, Cherif, Hosni, Ghazizadeh, Saber, Martinez, Oliver Wu, Sheng, Kai, Cousineau, Elsa, Lee, Seunghwan, Millecamps, Magali, Gao, Chan, Gilbert, Alice, Peirs, Cedric, Naeini, Reza Sharif, Ouellet, Jean, S. Stone, Laura, Haglund, Lisbet   +14 more
openaire   +3 more sources

Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: Investigation of Quantitative Gene Expression by qPCR

Current Issues in Molecular Biology
Cellular senescence plays a crucial role in skin aging, with senescent dermal fibroblasts contributing to reduced skin elasticity and increased inflammation.
Harald Kühnel, Markus Seiler, Barbara Feldhofer, Atefeh Ebrahimian, Michael Maurer   +4 more
doaj   +1 more source

Histone Deacetylase 9 Gene Deletion Ameliorates Aging‐Related Adipose Tissue Senescence and Mitochondrial Dysfunction in Mice

Aging Cell, Volume 25, Issue 5, May 2026.
Cellular senescence and mitochondrial dysfunction disrupt adipose tissue homeostasis during aging, but mechanisms remain unclear. HDAC9 expression increases with age in mouse adipose tissue and Hdac9 knockout mice showed reduced fat mass, senescence markers, and enhanced mitochondrial gene expression, respiration, and thiosulfate sulfurtransferase (Tst)
Brandee Goo, Samah Ahmadieh, Praneet Veerapaneni, Hong Shi, David S. Kim, Mourad Ogbi, Ronnie Chouhaita, Nicole Cyriac, Stephen Cave, Lingling Liu, Yong Zhang, Quansheng Du, Ha Won Kim, Yun Lei, Xin‐Yun Lu, Neal L. Weintraub   +15 more
wiley   +1 more source

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age. [PDF]

, 2019
We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology.
Chen, Chia-Chien, Conboy, Irina M, Conboy, Michael J, Etienne, Jessy, Gathwala, Ranveer, Kato, Cameron, Liu, Chao, Liu, Yutong, Mehdipour, Melod, Rehman, Maryam, Zuo, Yi   +10 more
core  

Targeting Hyperoxia‐Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants

Aging Cell, Volume 25, Issue 5, May 2026.
Supplemental oxygen is critical for premature infants. While initially beneficial, even moderate hyperoxia (< 60% O2) induces detrimental cellular senescence in developing airways with long‐lasting consequences. Senotherapeutics such as Fucoidan, Dasatinib (D) + Quercetin (D + Q), and mitochondrial‐targeted antioxidant MitoQ may be beneficial in ...
Maunick Lefin Koloko Ngassie, Li Y. Drake, Yi Zhu, Yamillie Ortiz, Daniel A. Pfeffer‐Kleemann, Michael A. Thompson, Samantha K. Hamrick, Christina M. Pabelick, Y. S. Prakash   +8 more
wiley   +1 more source

Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog [PDF]

The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging.
Boukos, Nikos, Evangelou, Konstantinos, Georgiou, Maria, Gorgoulis, Vassilis G., Havaki, Sophia, Kambas, Konstantinos, Kotopoulos, Nicholas, Kotsinas, Athanassios, Lagopati, Nefeli, Lougiakis, Nikolaos, Magkouta, Sophia, Marakos, Panagiotis, Palaiologou, Anastasia, Papaspyropoulos, Angelos, Petty, Russell, Pippa, Natassa, Pispas, Stergios, Pouli, Nicole, Sampaziotis, Fotios, Tamvakopoulos, Constantin, Thanos, Dimitris, Thanos, Dimitris Foivos, Veroutis, Dimitris   +22 more
core   +2 more sources

SPARC 2019 Fake news & home truths : Salford postgraduate annual research conference book of abstracts [PDF]

, 2019
Welcome to the Book of Abstracts for the 2019 SPARC conference. This year we not only celebrate the work of our PGRs but also our first ever Doctoral School Best Supervisor awards, which makes this year’s conference extra special.
Aarons, Toby, Abduljawad, SAMAH ABDULHADI S, Aboelkheir, Aya, Addis, Maria Chiara, Adeboye, OG, Adeniyi, Ibukun Abimbola, Adesina, Raphael Adeyinka, Ajisope, Tayo Ayanbola, Alanazi, Badriah Alhumaidh, Alghamdi, Wael, Alhajri, Mubarak, Ali, Iftikar, Alrehily, Faisal, Alresheedi, Nadi, Alshamsi, Ibrahim, Apejoye, Adeyanju, Asdullah, Muhammad Ashar, Baghaei, Milad, Barnes, EM, Barton, Lucy Susan, Blezard, Eve, Boahene, TS, Borun, Anna, Broeks, Lonneke, Carvalho, MARIA LUIZA DE ULHOA, Chinta, Sowmya, Clark, Anna, Dailah, HGH, Demonte, Philippa, Demonte, Philippa, Dixon, Tracy, Edwin, Marysa, Garbutt, Marrianne, Gbobaniyi, Andrea, Gbolagun, Vashti Suwa, Gbolagun, Vashti Suwa, Gilanliogullari, Nazemin, Greenhalgh, Stephen, Gunaratne, Pasan, Halilu gidado, ABUBAKAR, Hameed, Wael, Hassan, KABIRU JEGA, Hussain, Aisha, Iheme, MA, Iheme, MA, Iseghohimen, A, Jackson-Ware, Orla, Jones, Matthew Allan, Kassaman, Dinah, Kuharat, Sireetorn, Kulger, Katrin, Lenka, Jessica Lapshak, Macarthy, Ruth, Makarfi, UU, Mattix, Daniel, Mitchell, Louise, Moghaddam, Maryam Farzin, Mohammed, NUHU, Moore, Zoe, Morlando, Sonia, Namuguzi, Mary, Namukwaya, Caroline, Nnadi, Modestus Ikechukwu, Nuttall, John Robert, Nuttall, John Robert, Nwedu, Aaron Beryl, Odero, STEPHEN ODHIAMBO, Osmanu, Muniratu Aliu, Papathanasiou, Stamatia, Prasetyo, ANDHIKA PRIMA, Sadiq, Ibrahim, Safari, Nazila, Saffar, Nehal, Seekles, ML, Skidmore, Sue, Stoddart, Kirsten, Tilde, Aisha Ibrahim, Tomar, Neha, Toth, Fanni, Tran, Phuong Anh, White, Carolyn, Whitehead, Helen Claire, Willcock, MS, Willcock, MS, Wu, Mei Feng, Yadav, Richa, Yalmi, GILBERT, Yaradua, Kabir Hassan, Yoma, Matias, Yusup, Nor Hafizah   +89 more
core   +1 more source

Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies [PDF]

Aging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated disorders.
Fu, Tianlu Esther, Zhou, Zhongjun
core   +1 more source