Results 121 to 130 of about 9,248 (241)

The aging paradox of Cushing's syndrome: Stress without clear senescence?

Journal of Neuroendocrinology, Volume 38, Issue 6, June 2026.
Abstract Cushing's syndrome (CS), characterized by chronic endogenous hypercortisolism and disruption of the normal circadian cortisol rhythm, represents a unique human model for investigating the interplay between stress endocrinology and biological aging.
Israel Nunes Silveira, Alexandro Guterres   +1 more
wiley   +1 more source

Senolytic drugs dasatinib and quercetin combined with Carboplatin or Olaparib reduced the peritoneal and adipose tissue metastasis of ovarian cancer.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Chemotherapy and targeted drugs-induced senescent ovarian cancer cells that accumulate in peritoneal adipose tissue contribute significantly to chronic inflammation, disrupt homeostasis, and may fuel various aspects of cancer progression.
Lian Wang, Bing Xiong, Wei Lu, Yujie Cheng, Jihui Zhu, Guihai Ai, Xiaojie Zhang, Xiuni Liu, Zhongping Cheng   +8 more
semanticscholar   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the Notch pathway

International Journal of Molecular Medicine
The senolytics dasatinib and quercetin (DQ) alleviate age-related disorders. However, limited information is available regarding the effects of DQ on diabetic kidney disease (DKD).
Xinwang Zhu, Congxiao Zhang, Linlin Liu, Li Xu, Li Yao   +4 more
semanticscholar   +1 more source

Senolytic CAR T cells [PDF]

Nature Medicine, 2020
openaire   +2 more sources

Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies

International Journal of Molecular Sciences
Senolytic and senomorphic therapies have gained more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the “normal” cells. Aging is not a disease.
Monika Imb, Zsolt Véghelyi, Michael Maurer, Harald Kühnel   +3 more
semanticscholar   +1 more source

The dual role of cellular senescence in human tumor progression and therapy

MedComm
Cellular senescence, one of the hallmarks of cancer, is characterized by cell cycle arrest and the loss of most normal cellular functions while acquiring a hypersecretory, proinflammatory phenotype.
Liang Ma, Jie Yu, Yidian Fu, Xiaoyu He, Shengfang Ge, Renbing Jia, Ai Zhuang, Zhi Yang, Xianqun Fan   +8 more
doaj   +1 more source

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Clinical and Translational Medicine
Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong, Lu Dong, Qiongying Lv, Yutong Yin, Jiahui Zhao, Youning Ke, Shixuan Wang, Wei Zhang, Meng Wu   +8 more
doaj   +1 more source

Moving senolytics closer to the clinic in IPF

eBioMedicine, 2023
Daniel Kramer, Gautam George, Ross Summer   +2 more
openaire   +3 more sources

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source