Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending.
Andrea Bernetti +2 more
exaly +5 more sources
Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration [PDF]
Advanced ScienceChronic inflammation‐driven bone loss in aging compromises bone regeneration and further impairs the bone‐tendon interface (BTI). However, the cellular mechanisms by which inflammation exacerbates cellular senescence and consequently disrupts BTI healing
Lingzhi Kong +8 more
doaj +3 more sources
CellsRepurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We performed a repurposing screen of 240 clinically approved molecules in
Laura R Bramwell +2 more
exaly +6 more sources
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice [PDF]
ExplorationThe accumulation of senescent cells and their secretion of senescence‐associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Ang Ma, Qiaoli Shi, Yin Kwan Wong
exaly +3 more sources
PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling [PDF]
Frontiers in Cell and Developmental BiologyBackgroundCigarette smoke exposure is a major risk factor for oral cancer, partly due to its ability to induce early molecular alterations in the oral mucosa.
Nicla Flacco +10 more
doaj +2 more sources
Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models [PDF]
PharmaceuticsBackground/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Seokmuk Park +6 more
doaj +2 more sources
Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice [PDF]
EMBO Molecular MedicineCellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, senescent cell-based phenotypic screen of a small panel of natural products, we identified tomatidine, an aglycone of ...
Daniela G Costa +19 more
doaj +2 more sources
Metformin and butyrate attenuate chronic radiation proctitis by alleviating inflammation and macrophage senescence [PDF]
Frontiers in ImmunologyIntroductionChronic radiation proctitis (RP) is characterized by persistent inflammation and impaired tissue repair. This study investigates the potential of a metformin–butyrate (MeBu) combination to modulate radiation-induced senescence-associated ...
Mau-Shin Chi +7 more
doaj +2 more sources
International Journal of Immunopathology and PharmacologyObjective: This study aimed to evaluate whether EDTA-based targeted chelation therapy can act as senomorphic in chronic kidney disease (CKD)-induced vascular calcification.
Shivani Arora, Naren Vyavahare
exaly +2 more sources
An effective system for senescence modulating drug development using quantitative high-content analysis and high-throughput screening [PDF]
Communications BiologyStudy of cellular senescence is critical in aging research and anti-senescence therapy drug development. Current methods for the evaluation of the widely accepted cellular senescence marker senescence-associated beta galactosidase (SA-β-gal) activity ...
Yajie Hu +6 more
doaj +2 more sources