Results 1 to 10 of about 508 (143)
Could Hyaluronic Acid Be Considered as a Senomorphic Agent in Knee Osteoarthritis? A Systematic Review [PDF]
Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending.
Giacomo Fari +2 more
exaly +7 more sources
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar +10 more
doaj +13 more sources
CellsRepurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We performed a repurposing screen of 240 clinically approved molecules in
Lorna Harries, Laura R Bramwell
exaly +6 more sources
Frontiers in Neurology, 2023 Drosophila melanogaster is a valuable model organism for a wide range of biological exploration. The well-known advantages of D. melanogaster include its relatively simple biology, the ease with which it is genetically modified, the relatively low ...
Sean J Miller
exaly +5 more sources
Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells [PDF]
Biology, 2023 Aging is related to a low-grade and sterile inflammation called inflammaging, recognized as the main risk factor for age-related disease (ARD) development.
Giulia Matacchione +6 more
doaj +2 more sources
Arthritis Research & Therapy, 2023 Background Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence ...
Yu-Hsiu Chen +3 more
doaj +2 more sources
International Journal of Immunopathology and PharmacologyObjective: This study aimed to evaluate whether EDTA-based targeted chelation therapy can act as senomorphic in chronic kidney disease (CKD)-induced vascular calcification.
Naren Vyavahare, Shivani Lamba
exaly +2 more sources
Senopathies—Diseases Associated with Cellular Senescence
Biomolecules, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak +2 more
doaj +1 more source
Action Mechanisms of Small Extracellular Vesicles in Inflammaging
Life, 2022 The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process.
Rocío Mato-Basalo +10 more
doaj +1 more source
Experimental GerontologyCellular senescence is a central driver of organismal ageing and related pathologies, primarily promoting chronic inflammation and tissue dysfunction through the senescence-associated secretory phenotype (SASP).
Yue Kong +3 more
doaj +1 more source