Could Hyaluronic Acid Be Considered as a Senomorphic Agent in Knee Osteoarthritis? A Systematic Review [PDF]
Biomedicines, 2023 Background: Knee osteoarthritis (KOA) is one of the most common causes of disability in elderly patients and tends to be a major burden on social and health care spending.
Andrea Bernetti +2 more
exaly +7 more sources
Repurposing Drugs for Senotherapeutic Effect: Potential Senomorphic Effects of Female Synthetic Hormones [PDF]
CellsRepurposing previously approved drugs may fast track the route to the clinic for potential senotherapeutics and improves the inefficiency of the clinical drug development pipeline. We performed a repurposing screen of 240 clinically approved molecules in
Laura Bramwell, Lorna Harries
exaly +8 more sources
Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells [PDF]
Biology, 2023 Aging is related to a low-grade and sterile inflammation called inflammaging, recognized as the main risk factor for age-related disease (ARD) development.
Giulia Matacchione +6 more
doaj +5 more sources
Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar +10 more
doaj +10 more sources
Integrative Approaches to Treating Cellular Senescence in Kidney Disease [PDF]
Advanced ScienceCellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in ...
Tomoka Misawa +3 more
doaj +3 more sources
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice [PDF]
ExplorationThe accumulation of senescent cells and their secretion of senescence‐associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Yinhua Zhu, Jigang Wang
exaly +3 more sources
Targeted chelation therapy decreases NLRP3 expression by vascular cells and acts as senomorphic in chronic kidney disorder induced vascular calcification [PDF]
International Journal of Immunopathology and PharmacologyObjective: This study aimed to evaluate whether EDTA-based targeted chelation therapy can act as senomorphic in chronic kidney disease (CKD)-induced vascular calcification.
Shivani Lamba, Naren R Vyavahare
exaly +3 more sources
Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models [PDF]
PharmaceuticsBackground/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Seokmuk Park +6 more
doaj +2 more sources
Action Mechanisms of Small Extracellular Vesicles in Inflammaging [PDF]
Life, 2022 The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process.
Rocío Mato-Basalo +10 more
doaj +4 more sources
Defining Microbiota-Derived Metabolite Butyrate as a Senomorphic: Therapeutic Potential in the Age-Related T Cell Senescence. [PDF]
Aging CellAdvancing age is accompanied by an accumulation of senescent T cells that secrete pro‐inflammatory senescence‐associated secretory phenotype (SASP) molecules. Gut‐microbiota‐derived signals are increasingly recognised as immunomodulators.
Rees NP +6 more
europepmc +3 more sources