Results 31 to 40 of about 1,245 (145)
Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases. [PDF]
Int J Mol SciCellular senescence, a state of stable cell cycle arrest accompanied by a complex senescence-associated secretory phenotype (SASP), is a fundamental biological process implicated as a key driver of lung aging and lung age-related diseases (LARDs).
Ozdemir SA +5 more
europepmc +4 more sources
Biology, 2023 Aging is related to a low-grade and sterile inflammation called inflammaging, recognized as the main risk factor for age-related disease (ARD) development.
Giulia Matacchione +6 more
doaj +1 more source
Action Mechanisms of Small Extracellular Vesicles in Inflammaging
Life, 2022 The accumulation process of proinflammatory components in the body due to aging influences intercellular communication and is known as inflammaging. This biological mechanism relates the development of inflammation to the aging process.
Rocío Mato-Basalo +10 more
doaj +1 more source
Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect. [PDF]
Int J Mol SciCellular senescence is closely connected with cancer progression, recurrence, and metastasis. Senotherapy aims to soothe the harmful effects of senescent cells either by inducing their apoptosis (senolytic) or by suppressing the senescence-associated secretory phenotype (SASP) (senomorphic).
Henschke A +5 more
europepmc +5 more sources
Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis
International Journal of Molecular Sciences, 2022 Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA treatment is currently not available. Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in the etiology of OA.
Pei-Wei Weng +7 more
openaire +2 more sources
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin [PDF]
Science Advances, 2020 A microRNA-activated pathway in maternal diabetes–induced neuroepithelial cell senescence leads to neural tube defects.
Cheng Xu +6 more
openaire +3 more sources
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission
Biomedicine & Pharmacotherapy, 2023 With an aging population and the numerous health impacts associated with old age, the identification of anti-aging drugs has become an important new research direction. Although mitochondria have been recognized to affect aging, anti-aging drugs specifically targeting the mitochondria are less well characterized. In this study, diphenyleneiodonium (DPI)
Keng-Mao Liao +6 more
openaire +2 more sources
Metabolic changes in aging humans: current evidence and therapeutic strategies
The Journal of Clinical Investigation, 2022 Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes.
Allyson K. Palmer, Michael D. Jensen
doaj +1 more source
Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced response to vaccine regimens.
Carla Luís +13 more
openaire +3 more sources
Aging, Cellular Senescence, and Progressive Multiple Sclerosis
Frontiers in Cellular Neuroscience, 2020 Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging.
Dimitrios Papadopoulos +5 more
doaj +1 more source