Immunotherapeutic approach to reduce senescent cells and alleviate senescence-associated secretory phenotype in mice [PDF]
, 2023 Accumulation of senescent cells (SNCs) with a senescence-associated secretory phenotype (SASP) has been implicated as a major source of chronic sterile inflammation leading to many age-related pathologies.
Berrien-Elliott, Melissa M +10 more
core +2 more sources
Heterogeneity of Cellular Senescence, Senotyping, and Targeting by Senolytics and Senomorphics in Lung Diseases. [PDF]
Int J Mol SciCellular senescence, a state of stable cell cycle arrest accompanied by a complex senescence-associated secretory phenotype (SASP), is a fundamental biological process implicated as a key driver of lung aging and lung age-related diseases (LARDs).
Ozdemir SA +5 more
europepmc +3 more sources
Endothelial Senescence and the Chronic Vascular Diseases: Challenges and Therapeutic Opportunities in Atherosclerosis [PDF]
, 2022 Atherosclerosis is probably one of the paradigms of disease linked to aging. Underlying the physiopathology of atherosclerosis are cellular senescence, oxidative stress, and inflammation.
Alique Aguilar, Matilde +5 more
core +1 more source
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin [PDF]
Science Advances, 2020 A microRNA-activated pathway in maternal diabetes–induced neuroepithelial cell senescence leads to neural tube defects.
Cheng Xu +6 more
openaire +3 more sources
Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect. [PDF]
Int J Mol SciCellular senescence is closely connected with cancer progression, recurrence, and metastasis. Senotherapy aims to soothe the harmful effects of senescent cells either by inducing their apoptosis (senolytic) or by suppressing the senescence-associated secretory phenotype (SASP) (senomorphic).
Henschke A +5 more
europepmc +3 more sources
An update on RPE cell senescence as a key contributor to age-related macular degeneration: support from current and experimental treatments [PDF]
, 2023 Background: Age-related macular degeneration (AMD) is a major cause of vision loss. Its prevalence has increased over the past decade. This increase is partly due to the scarcity of preventive and therapeutic interventions for this disorder, except when ...
Kozlowski , Michael R
core +2 more sources
Arthritis Research & Therapy, 2023 Background Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence ...
Yu-Hsiu Chen +3 more
doaj +1 more source
Exploring the Communication of the SASP:Dynamic, Interactive, and Adaptive Effects on the Microenvironment [PDF]
, 2023 Cellular senescence is a complex cell state that can occur during physiological ageing or after exposure to stress signals, regardless of age. It is a dynamic process that continuously evolves in a context-dependent manner.
Bouriez, Inès +5 more
core +2 more sources
Senescence under appraisal: hopes and challenges revisited. [PDF]
, 2021 In recent years, cellular senescence has become the focus of attention in multiple areas of biomedical research. Typically defined as an irreversible cell cycle arrest accompanied by increased cellular growth, metabolic activity and by a characteristic ...
Davan-Wetton, CSA +3 more
core +1 more source
Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell-Derived Extracellular Vesicles. [PDF]
Aging CellABSTRACTExtracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned as senomorphics to suppress markers of senescence and the inflammatory senescence‐associated secretory ...
Zhang T +11 more
europepmc +3 more sources