Results 31 to 40 of about 508 (143)
Metabolic changes in aging humans: current evidence and therapeutic strategies
The Journal of Clinical Investigation, 2022 Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes.
Allyson K. Palmer, Michael D. Jensen
doaj +1 more source
Aging, Cellular Senescence, and Progressive Multiple Sclerosis
Frontiers in Cellular Neuroscience, 2020 Aging is one of the most important risk factors for the development of several neurodegenerative diseases including progressive multiple sclerosis (MS). Cellular senescence (CS) is a key biological process underlying aging.
Dimitrios Papadopoulos +5 more
doaj +1 more source
Senotherapeutics for Knee Osteoarthritis
Medicinal Research Reviews, EarlyView.ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman +6 more
wiley +1 more source
PharmaceuticsBackground/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Seokmuk Park +6 more
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Frontiers in Aging Neuroscience, 2022 To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties.
Zofia Chrienova +17 more
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The Journal of Dermatology, EarlyView.ABSTRACT Hard‐to‐heal wounds, such as diabetic foot ulcers and pressure injuries, pose major clinical challenges due to chronic inflammation and cellular senescence. Cellular senescence‐associated mechanisms, including stress‐responsive p53/p21 signaling and senescence‐associated secretory phenotype‐related inflammation, contribute to impaired wound ...
Daijiro Haba +6 more
wiley +1 more source
, 2021 Chemotherapy-induced senescent cancer cells secrete several factors in their microenvironment called SASP. Accumulated evidence states that SASP is responsible for some of the harmful effects of chemotherapy such as drug resistance and the induction of ...
Şimay Demir, Yaprak Dilber +7 more
core +1 more source
Senescence, regulators of alternative splicing and effects of trametinib treatment in progeroid syndromes [PDF]
, 2023 Progeroid syndromes such as Hutchinson Gilford Progeroid syndrome (HGPS), Werner syndrome (WS) and Cockayne syndrome (CS), result in severely reduced lifespans and premature ageing. Normal senescent cells show splicing factor dysregulation, which has not
LW Harries (21821876) +1 more
core +3 more sources
Frontiers in ImmunologyIntroductionChronic radiation proctitis (RP) is characterized by persistent inflammation and impaired tissue repair. This study investigates the potential of a metformin–butyrate (MeBu) combination to modulate radiation-induced senescence-associated ...
Mau-Shin Chi +7 more
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Increased cell senescence in human metabolic disorders
The Journal of Clinical Investigation, 2023 Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and aging increases the burden of CS in all major metabolic tissues.
Rosa Spinelli +6 more
doaj +1 more source