Results 51 to 60 of about 1,609 (186)

Repurposing digoxin for geroprotection in patients with frailty and multimorbidity [PDF]

, 2023
The geroscience hypothesis proposes biological hallmarks of ageing are modifiable. Increasing evidence supports targeting these hallmarks with therapeutics could prevent and ameliorate age-related conditions - collectively termed "geroprotector drugs ...
Bunting, Karina V, Jackson, Thomas, Kotecha, Dipak, Lee, Helena, Wilson, Daisy   +4 more
core   +1 more source

Increased cell senescence in human metabolic disorders

The Journal of Clinical Investigation, 2023
Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and aging increases the burden of CS in all major metabolic tissues.
Rosa Spinelli, Ritesh Kumar Baboota, Silvia Gogg, Francesco Beguinot, Matthias Blüher, Annika Nerstedt, Ulf Smith   +6 more
doaj   +1 more source

Investigating the Effects of Chelidonic Acid on Oxidative Stress-Induced Premature Cellular Senescence in Human Skin Fibroblast Cells

Life
This study investigated the effects of chelidonic acid (CA) on hydrogen peroxide (H2O2) induced cellular senescence in human skin fibroblast cells (BJ).
Burcu Turkoglu, Banu Mansuroglu
doaj   +1 more source

Emerging roles of senolytics/senomorphics in HIV-related co-morbidities

Biochemical Pharmacology
Human immunodeficiency virus (HIV) is known to cause cellular senescence and inflammation among infected individuals. While the traditional antiretroviral therapies (ART) have allowed the once fatal infection to be managed effectively, the quality of life of HIV patients on prolonged ART use is still inferior. Most of these individuals suffer from life-
Kaur, Gagandeep, Sohanur Rahman, Md., Shaikh, Sadiya, Panda, Kingshuk, Chinnapaiyan, Srinivasan, Santiago Estevez, Maria, Xia, Li, Unwalla, Hoshang, Rahman, Irfan   +8 more
openaire   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

PI3K/mTOR inhibition attenuates cigarette smoke-induced senescence and SASP in oral fibroblasts: implications for tumor microenvironment remodeling

Frontiers in Cell and Developmental Biology
BackgroundCigarette smoke exposure is a major risk factor for oral cancer, partly due to its ability to induce early molecular alterations in the oral mucosa.
Nicla Flacco, Cristina Estornut, Inés Roger, Inés Roger, Inés Roger, Inés Roger, Pilar Ribera, Germán Sánchez-Herrera, Silvia Trujillo-Barbera, Martín Pérez-Leal, Martín Pérez-Leal   +10 more
doaj   +1 more source

Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues [PDF]

, 2023
BACKGROUND: Doxorubicin is an essential cancer treatment, but its usefulness is hampered by the occurrence of cardiotoxicity. Nevertheless, the pathophysiology underlying doxorubicin-induced cardiotoxicity and the respective molecular mechanisms are ...
Arevalo Gomez, Karla F, Bliley, Jacqueline M, Bomer, Nils, de Boer, Rudolf A, Deiman, Frederik E, Demaria, Marco, Dias, Itamar B, Feinberg, Adam W, Gietema, Jourik, Hilfiker-Kleiner, Denise, Hoes, Martijn F, Linders, Annet N, Markousis Mavrogenis, George, Nehme, Jamil, Ovchinnikova, Ekaterina S, Sillje, Herman H W, van der Meer, Peter, van Laake, Linda W, Vermeer, Mathilde C S C, Vink, Aryan, Westenbrink, Daan   +20 more
core  

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Sex-Specific Protection of Endothelial Function after Vascular Ischemia/Reperfusion Injury by the Senomorphic Agent Ruxolitinib

International Journal of Molecular Sciences, 2023
Ischemia/reperfusion (I/R)-induced endothelial dysfunction occurs in various cardiovascular disorders. I/R injury is partially driven by the release of cytokines. Known for its use in senotherapy, the JAK inhibitor ruxolitinib is able to block the release of cytokines.
Lars Saemann, Paula Naujoks, Lotta Hartrumpf, Sabine Pohl, Andreas Simm, Gábor Szabó   +5 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source