Results 71 to 80 of about 1,245 (145)
Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.ABSTRACT Ovarian aging is characterized by the reduction of the follicular pool and a progressive loss in oocyte quality. Although these changes have initially been attributed to oocyte alterations, increasing evidence indicates that stromal deterioration plays a central role in this process.
Stefhani Martins Barcelos +3 more
wiley +1 more source
Editorial: Cellular senescence in physiology and pathophysiology
Frontiers in Physiology, 2023 Mustafa Ark, Mohammad Nasir Uddin
doaj +1 more source
The role of p21 in cellular senescence and aging-related diseases
Molecules and Cells: During the aging process or disease progression, normal cells and tissues in the body undergo various stresses, leading to cell damage and the need for repair, adaptation, apoptosis, or defense responses.
Jiayu Yan +6 more
doaj +1 more source
Nature CommunicationsSenescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang +14 more
doaj +1 more source
Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke
PharmaceuticalsAging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier +2 more
doaj +1 more source
Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice
FEBS Open BioSARS‐CoV‐2 infection can lead to severe COVID‐19, particularly in elderly individuals and those with compromised immunity. Cellular senescence has been implicated as a key pathogenic mechanism.
Ju Hwan Jeong +5 more
doaj +1 more source
SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY
Central Asian Journal of Medical Hypotheses and EthicsAging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related diseases. Targeting cellular senescence has emerged as a novel therapeutic paradigm in geroscience.
Timur Saliev, Prim B. Singh
openaire +1 more source
The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications
Experimental GerontologyOsteoarthritis (OA) is a common and debilitating joint disorder, with its pathogenesis significantly influenced by factors such as aging and obesity.
Kai Huang, Haili Cai
doaj +1 more source
Pyrroloquinoline Quinone Is an Effective Senomorphic Agent to Target the Pro-Inflammatory Phenotype of Senescent Cells. [PDF]
Aging CellABSTRACTCellular senescence is an aging‐related mechanism characterized by cell cycle arrest, macromolecular alterations, and a senescence‐associated secretory phenotype (SASP). Recent preclinical trials established that senolytic drugs, which target survival mechanisms of senescent cells, can effectively intervene in age‐related pathologies.
Jiang B +6 more
europepmc +3 more sources
Apigenin and Phloretin Combination for Skin Aging and Hyperpigmentation Regulation
CosmeticsMelasma is a pathology with multifactorial causes that results in hyperpigmentation of sun-exposed areas, particularly facial skin. New treatments targeting the different factors regulating this condition need to be effective with and have limited ...
Alfredo Martínez-Gutiérrez +3 more
doaj +1 more source