Results 71 to 80 of about 508 (143)

Table2_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.XLSX

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

Editorial: Cellular senescence in physiology and pathophysiology

Frontiers in Physiology, 2023
Mustafa Ark, Mohammad Nasir Uddin
doaj   +1 more source

Tomatidine is a senotherapeutic compound that improves cognitive function and reduces cellular senescence in aged mice

EMBO Molecular Medicine
Cellular senescence drives aging and age-related dysfunction across multiple tissues, including the brain. Through a high-content, senescent cell-based phenotypic screen of a small panel of natural products, we identified tomatidine, an aglycone of ...
Daniela G Costa, Lucy M Gee, Gung Lee, Lilian Sales Gomez, Ana Catarina Franco, Maria Grazia Vizioli, Karla Valdivieso, Lei J Zhang, Nick Pirius, Helene Martini, Rebecca A Porritt, Dominik Saul, Claudia Cavadas, Scott Ebert, Nathan K LeBrasseur, Sundeep Khosla, João F Passos, Christopher M Adams, Paul D Robbins, Diana Jurk   +19 more
doaj   +1 more source

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP). [PDF]

Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a Drosophila model to investigate the effects of radiation-induced DNA damage on the intestine.
Campisi, Judith, Watson, Mark, Hilsabeck, Tyler A U, Kapahi, Pankaj, Pattavina, B, Bons, Joanna, Schilling, Birgit, Sharma, Amit, Basisty, Nathan, Bar, Sudipta, López-Domínguez, José Alberto   +10 more
core   +1 more source

Integrative bioinformatic and in vitro analysis identifies putative lipid metabolism-associated RAGE network components in murine adipocyte senescence

Scientific Reports
Cellular senescence in adipocytes is a key driver of age-related inflammation and metabolic impairment. The present study explored the crosstalk between lipid metabolism and the RAGE network in adipocytes through an integrated bioinformatic and in vitro ...
Ashish Kumar, Kavitha Thirumurugan
doaj   +1 more source

Multi-omics analysis and integrative approach to evaluate pharmaco-clinical efficacy of a novel combination of active ingredients on senescence and causes of aging

, 2023
International audienceSkin aging is the consequence of intrinsic and extrinsic factors. At the cellular level, accumulation of senescent cells (SC) is also involved in skin aging.
Bogdanowicz, Patrick, Doat, Gautier, Duplan, Hélène, Bianchi, Pascale, Jamin, Emilien, Debrauwer, Laurent, Jacques-Jamin, Carine, Bensadoun, Paul, Bessou-Touya, Sandrine, Le Chevère, Marie, Alvarez-Georges, Sandrine, Lemaitre, Jean-Marc   +11 more
core   +1 more source

Targeting Aging and Diseases Associated with Ferroptosis and Senescence Through Modulation of Iron, Oxidative Stress and Lipid Peroxidation

Antioxidants
Ferroptosis and senescence are unique cellular processes that lead to irreversible cell abnormalities and tissue damage in many diseases, such as cancer, neurodegeneration, cardiac, liver, and kidney damage.
Malamati Kourti, George J. Kontoghiorghes   +1 more
doaj   +1 more source

Isatis tinctoria L. Leaf Extract Inhibits Replicative Senescence in Dermal Fibroblasts by Regulating mTOR-NF-κB-SASP Signaling

, 2022
Senescent fibroblasts progressively deteriorate the functional properties of skin tissue. Senescent cells secrete senescence-associated secretory phenotype (SASP) factor, which causes the aging of surrounding non-senescent cells and accelerates aging in ...
Woo, Jieun, Eunae Cho, Seoungwoo Shin, Deokhoon Park, Hyanggi Ji, Jieun Woo, Eunsun Jung, Ji, Hyanggi, Jung, Eunsun, Shin, Seoungwoo, Kim, Junoh, Kim, Youngseok, Park, Deokhoon, Junoh Kim, Cho, Eunae, Ryu, Dehun, Dehun Ryu, Youngseok Kim   +17 more
core   +1 more source

Table3_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.XLS

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

The role of p21 in cellular senescence and aging-related diseases

Molecules and Cells
: During the aging process or disease progression, normal cells and tissues in the body undergo various stresses, leading to cell damage and the need for repair, adaptation, apoptosis, or defense responses.
Jiayu Yan, Siyi Chen, Zimei Yi, Ruowen Zhao, Jiayu Zhu, Shuwen Ding, Junhua Wu   +6 more
doaj   +1 more source