Results 61 to 70 of about 508 (143)

Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice

Advanced Science, Volume 13, Issue 47, 24 August 2026.
The biomimetic self‐assembly nanomedicine reversing atherosclerosis via senotherapy strategy. ABSTRACT The greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and ...
Yuhan Tian, Yanrui Yang, Qiuyu Li, Ying Hu, Qin Hu, Shasha Ran, Siyu Zhou, Xiujuan Yang, Shanshan Li, Qixiong Zhang   +9 more
wiley   +1 more source

CELLULAR SENESCENCE: MOLECULAR MECHANISMS AND SENOLYTIC AND SENOMORPHIC STRATEGIES

Cellular senescence is an irreversible cell cycle arrest associated with chronic inflammation and age-related diseases. Senescent cells develop a senescence-associated secretory phenotype (SASP), largely regulated by NF-κB signaling, which promotes ...
Nargiza Hamzayeva, Gulnoza Jakhangirova, Anvar Normatov, Zilola Rabimova, Rakhmonova Dildor, Madina Khamidova, Mohira Khamidova, Dilafruz Zaynutdinova   +7 more
core   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, Volume 7, Issue 4, August 2026.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Distinct decidualization and senomorphic responses in endometrial vs. menstrual blood stem/stromal cells: implications for reproductive therapies

Stem Cell Research & Therapy
Background Decidualization, the process of endometrial stem/stromal cell (EnSCs) differentiation, is essential for embryo implantation and pregnancy maintenance. Menstrual blood-derived stem/stromal cells (MenSCs), although often considered as surrogates
Negar Vanaki, Banafsheh Tavangar, Maryam Darzi, Soheila Arefi, Ebrahim Mirzadegan, Maryam Mousavi, Fazel Shokri, Amir-Hassan Zarnani   +7 more
doaj   +1 more source

Ammonia Metabolism in the Aging Liver: Emerging Mechanistic Insights

Aging Cell, Volume 25, Issue 8, August 2026.
Liver aging may weaken ammonia‐detoxification reserve by disrupting mitochondrial ureagenesis, GS‐mediated scavenging, glutamine metabolism, and metabolic zonation. This emerging framework links impaired nitrogen handling to potential hepatic stress amplification and systemic crosstalk, while highlighting the need for direct validation in physiological
Heng Zhang, Guangyu Liang, Anding Liu
wiley   +1 more source

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science
Cellular senescence is a cell fate triggered by stressful stimuli and displays a hypersecretory feature, the senescence‐associated secretory phenotype (SASP). Senescent cell burden increases with aging and contributes to age‐related organ dysfunction and
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
doaj   +1 more source

Mesenchymal Stromal Cell Rejuvenation Strategies to Enhance Clinical Translation in Cell Therapy

Aging Cell, Volume 25, Issue 8, August 2026.
MSC rejuvenation strategies and functional outcomes. Aging‐associated alterations in MSCs, including increased IL‐6/IL‐8 secretion, ROS accumulation, epigenetic drift, and mitochondrial dysfunction, impair stemness. Rejuvenation approaches, epigenetic modulation (VPA, AZAc, OSKM, TERT), metabolic interventions (resveratrol, calcitriol, NMD, asprosin ...
Astrid Sodomaco, Irene Bernardi, Aretha Rambaldi, Pierluigi Lombardi, Maura Rossi, Francesca Paris, Lucia Manzoli, Stefano Ratti, Francesco Alviano   +8 more
wiley   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science
Chronic inflammation‐driven bone loss in aging compromises bone regeneration and further impairs the bone‐tendon interface (BTI). However, the cellular mechanisms by which inflammation exacerbates cellular senescence and consequently disrupts BTI healing
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
doaj   +1 more source

Characterizing the SASP‐Dependent Paracrine Spreading of Senescence Between Human Brain Cell Types

Aging Cell, Volume 25, Issue 8, August 2026.
In this paper, we characterized the brain cell‐type‐specific SASP and defined the directionality of a paracrine spreading of senescence phenotypes. We unraveled ligand‐receptor pairs underlying this spreading and showed that inhibiting this interaction ameliorates senescence dissemination.
Taylor Russo, Markus Riessland
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, Volume 16, Issue 7, Page 1370-1386, July 2026.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source