Results 41 to 50 of about 1,609 (186)

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent. [PDF]

Aging Dis
Assessing impact on the hallmarks of aging has emerged as a novel method for prioritizing dual-purpose longevity therapeutic targets and developing drugs simultaneously targeting aging and disease. Cellular senescence, a central hallmark of aging, progressively induces cellular growth arrest and accelerates the production of a pro-inflammatory ...
Tang Q, Xiao D, Veviorskiy A, Xin Y, Lok SWY, Pulous FE, Zhang P, Zhu Y, Ma Y, Hu X, Gu S, Zong C, Mukba S, Korzinkin M, Pun FW, Zhang M, Aliper A, Wu L, Ren F, Zhang L, Zhavoronkov A.   +20 more
europepmc   +3 more sources

Mitigating Pro-Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy. [PDF]

Aging Cell
ABSTRACT Senescent cells are known to contribute to aging and age‐related diseases. One key way they influence aging is by secreting senescence‐associated secretory phenotype (SASP) factors along with several damage‐associated molecular pattern (DAMP) molecules.
Barkovskaya A, Brauning A, Thambala A, Bhardwaj K, Chamoli M, Rane A, Andersen JK, Sharma A.   +7 more
europepmc   +3 more sources

Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy

Aging Cell, 2023
AbstractAging is a major risk factor for most chronic disorders, for which cellular senescence is one of the central hallmarks. Senescent cells develop the pro‐inflammatory senescence‐associated secretory phenotype (SASP), which significantly contributes to organismal aging and age‐related disorders.
Hanxin Liu, Qixia Xu, Halidan Wufuer, Zi Li, Rong Sun, Zhirui Jiang, Xuefeng Dou, Qiang Fu, Judith Campisi, Yu Sun   +9 more
openaire   +2 more sources

On the wake of metformin: do anti-diabetic SGLT2 inhibitors exert anti-aging effects? [PDF]

, 2023
Here we propose that SGLT2 inhibitors (SGLT2i), a class of drugs primarily used to treat type 2 diabetes, could also be repositioned as anti-aging senomorphic drugs (agents that prevent the extrinsic harmful effects of senescent cells).
Ambrosino, Concetta, Barbieri, Michelangela, Olivieri, Fabiola, Paolisso, Giuseppe, Rizzo, Maria Rosaria, Scisciola, Lucia   +5 more
core   +2 more sources

A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the In Vivo Tracking of Cellular Senescence [PDF]

, 2021
Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases.
Blandez, Juan F., Galiana, Irene, González Gualda, Estela, Lozano Torres, Beatriz, López Domínguez, José A., Martínez Máñez, Ramón, Muñoz Espín, Daniel, Paez-Ribes, Marta, Rovira, Miguel, Sancenón, Félix, Serrano Marugán, Manuel   +10 more
core   +2 more sources

Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest [PDF]

, 2023
Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated
Abdelmohsen K., Anerillas C., De S., Donega S., Fan J., Ferrucci L., Gorospe M., Herman A. B., Idda M. L., Johnson P. F., Martindale J. L., Mazan-Mamczarz K., Munk R., Piao Y., Rossi M., Shin C. H., Tsitsipatis D., Yang X.   +17 more
core   +1 more source

Metabolic changes in aging humans: current evidence and therapeutic strategies

The Journal of Clinical Investigation, 2022
Aging and metabolism are inextricably linked, and many age-related changes in body composition, including increased central adiposity and sarcopenia, have underpinnings in fundamental aging processes.
Allyson K. Palmer, Michael D. Jensen
doaj   +1 more source

Discovery of small molecule mechanistic target of rapamycin inhibitors as anti-aging and anti-cancer therapeutics

Frontiers in Aging Neuroscience, 2022
To date, the most studied drug in anti-aging research is the mTOR inhibitor – rapamycin. Despite its almost perfect anti-aging profile, rapamycin exerts one significant limitation – inappropriate physicochemical properties.
Zofia Chrienova, David Rysanek, Patrik Oleksak, Dorota Stary, Dorota Stary, Marek Bajda, Milan Reinis, Romana Mikyskova, Ondrej Novotny, Rudolf Andrys, Adam Skarka, Pavla Vasicova, Josef Novak, Martin Valis, Martin Valis, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova   +17 more
doaj   +1 more source

Targeting Senescence: A Review of Senolytics and Senomorphics in Anti-Aging Interventions. [PDF]

Biomolecules
Cellular senescence is a fundamental mechanism in aging, marked by irreversible growth arrest and diverse functional changes, including, but not limited to, the development of a senescence-associated secretory phenotype (SASP). While transient senescence contributes to beneficial processes such as tissue repair and tumor suppression, the persistent ...
Saliev T, Singh PB.
europepmc   +3 more sources

Nutritional senolytics and senomorphics: Implications to immune cells metabolism and aging – from theory to practice

Frontiers in Nutrition, 2022
Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced response to vaccine regimens.
Carla Luís, Carla Luís, Ana T. Maduro, Ana T. Maduro, Paula Pereira, Paula Pereira, Paula Pereira, José João Mendes, José João Mendes, Raquel Soares, Raquel Soares, Renata Ramalho, Renata Ramalho, Renata Ramalho   +13 more
openaire   +3 more sources