Results 21 to 30 of about 1,245 (145)

The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway

International Journal of Immunopathology and Pharmacology
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence.
Maha M Aziz, Marwa M El-Sheikh, Marwa A Mohamed, Sahar S Abdelrahman, Mai H Mekkawy   +4 more
doaj   +3 more sources

Frentizole derivatives with mTOR inhibiting and senomorphic properties [PDF]

Biomedicine & Pharmacotherapy, 2023
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has been revealed.
Zofia Chrienova, David Rysanek, Josef Novak, Pavla Vasicova, Patrik Oleksak, Rudolf Andrys, Adam Skarka, Jelena Dumanovic, Zoran Milovanovic, Vesna Jacevic, Marketa Chvojkova, Kristina Holubova, Karel Vales, Veronika Skoupilova, Marian Valko, Klaudia Jomova, Suliman Y. Alomar, Fernanda D. Botelho, Tanos C.C. Franca, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova   +21 more
openaire   +3 more sources

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]

The FEBS Journal, 2022
The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, Laura J. Niedernhofer, Paul D. Robbins   +4 more
openaire   +2 more sources

Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics. [PDF]

Drug Des Devel Ther
Cellular senescence is a fundamental characteristic of aging, marked by permanent cell cycle cessation and the release of pro-inflammatory mediators. Although senescence plays advantageous roles in tissue regeneration and tumor suppression, its accumulation leads to aging-related illnesses and functional deterioration.This review examines the processes
Alum EU, Izah SC, Uti DE, Ugwu OP, Betiang PA, Basajja M, Ejemot-Nwadiaro RI.   +6 more
europepmc   +5 more sources

HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells [PDF]

Aging, 2021
The senescence of retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a predominant chaperone that regulates cellular homeostasis under divergent physio-pathological conditions including senescence.
Chen, Dan-Dan, Peng, Xuyan, Wang, Yuxuan, Jiang, Mingjun, Xue, Mengjiao, Shang, Guohui, Liu, Xuhui, Jia, Xiaolin, Liu, Baixue, Lu, Yingwei, Mu, Hongmei, Zhang, Fengyan, Hu, Yanzhong   +12 more
openaire   +2 more sources

PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration

Advanced Science
Cellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting senescence markers and the senescence‐associated secretory phenotype (SASP), remains
Sheng Liu, Kanglu Li, Yuxin He, Sheng Chen, Wenbo Yang, Xuanzuo Chen, Shiqing Feng, Liming Xiong, Yizhong Peng, Zengwu Shao   +9 more
doaj   +3 more sources

Senopathies—Diseases Associated with Cellular Senescence

Biomolecules, 2023
Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak, Markus Schosserer, Johannes Grillari   +2 more
doaj   +1 more source

The Aging Microenvironment Shapes Angiogenic Remodeling in IBD-Associated Colorectal Carcinogenesis. [PDF]

Aging Cell
In IBD, chronic inflammation promotes cellular senescence across epithelial, stromal, endothelial, and immune compartments. The resulting SASP drives pathological angiogenesis, vascular dysfunction, hypoxia, and immune suppression, thereby facilitating progression from inflammation to dysplasia and colitis‐associated colorectal cancer.
Duan R, Chen Q, Xu Y, Yan Y, Jiang S.
europepmc   +2 more sources

Synergistic targeting of senolytic and senomorphic action with dual-engineered biomimetic macrophage nanovesicles for mitigating osteoarthritis

Bioactive Materials
Osteoarthritis (OA), a leading cause of chronic disability worldwide, is increasingly recognized to be driven by the accumulation of senescent chondrocytes (sCDs) and their deleterious pro-inflammatory senescence-associated secretory phenotype (SASP ...
Wenan Peng, Ziming Wang, Zenan Zhuang, Simin Zeng, Yu Xia, Qiwen Chen, Xuan Bai, Ying Tang, Cui Huang, Xianzheng Zhang   +9 more
doaj   +4 more sources

Synergistic roles of CBX4 chromo and SIM domains in regulating senescence of primary human osteoarthritic chondrocytes

Arthritis Research & Therapy, 2023
Background Cellular senescence is a critical factor contributing to osteoarthritis (OA). Overexpression of chromobox homolog 4 (CBX4) in a mouse system was demonstrated to alleviate post-traumatic osteoarthritis (PTOA) by reducing cellular senescence ...
Yu-Hsiu Chen, Xin Zhang, David Attarian, Virginia Byers Kraus   +3 more
doaj   +1 more source