Results 21 to 30 of about 508 (143)
Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues [PDF]
, 2023 BACKGROUND: Doxorubicin is an essential cancer treatment, but its usefulness is hampered by the occurrence of cardiotoxicity. Nevertheless, the pathophysiology underlying doxorubicin-induced cardiotoxicity and the respective molecular mechanisms are ...
Hoes, Martijn F +20 more
core +3 more sources
Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin [PDF]
Science Advances, 2020 A microRNA-activated pathway in maternal diabetes–induced neuroepithelial cell senescence leads to neural tube defects.
Cheng Xu +6 more
openaire +3 more sources
Investigating the potential senomorphic properties of SCFA butyrate on aged T cells. [PDF]
Ageing is accompanied by remodelling of the T cell pool and a hallmark of immune ageing is the expansion of senescent T cells in aged hosts. Senescent T cells express markers of DNA damage and cell cycle arrest markers, elevated production of pro ...
Paddison Rees, Nia
core +5 more sources
Developing a Senomorphic Treatment Strategy in Osteoarthritis
, 2022 Osteoarthritis (OA) is the most common form of arthritis in the population worldwide, resulting in significant disabilities. Currently, no treatments can prevent or reverse the development of OA.
Chen, Yu-Hsiu
core +1 more source
Role of GDF15/MAPK14 Axis in Chondrocyte Senescence as a Novel Senomorphic Agent in Osteoarthritis
International Journal of Molecular Sciences, 2022 Osteoarthritis (OA) is most prevalent in older individuals and exerts a heavy social and economic burden. However, an effective and noninvasive approach to OA treatment is currently not available. Chondrocyte senescence has recently been proposed as a key pathogenic mechanism in the etiology of OA.
Pei-Wei Weng +7 more
openaire +2 more sources
, 2023 Ischemia/reperfusion (I/R)-induced endothelial dysfunction occurs in various cardiovascular disorders. I/R injury is partially driven by the release of cytokines.
Sabine Pohl +5 more
core +1 more source
Senomorphic effect of diphenyleneiodonium through AMPK/MFF/DRP1 mediated mitochondrial fission
Biomedicine & Pharmacotherapy, 2023 With an aging population and the numerous health impacts associated with old age, the identification of anti-aging drugs has become an important new research direction. Although mitochondria have been recognized to affect aging, anti-aging drugs specifically targeting the mitochondria are less well characterized. In this study, diphenyleneiodonium (DPI)
Keng-Mao Liao +6 more
openaire +2 more sources
Frontiers in Nutrition, 2022 Aging is a natural physiological process, but one that poses major challenges in an increasingly aging society prone to greater health risks such as diabetes, cardiovascular disease, cancer, frailty, increased susceptibility to infection, and reduced response to vaccine regimens.
Carla Luís +13 more
openaire +3 more sources
Frontiers in Cell and Developmental BiologyBackgroundCigarette smoke exposure is a major risk factor for oral cancer, partly due to its ability to induce early molecular alterations in the oral mucosa.
Nicla Flacco +10 more
doaj +1 more source
LifeThis study investigated the effects of chelidonic acid (CA) on hydrogen peroxide (H2O2) induced cellular senescence in human skin fibroblast cells (BJ).
Burcu Turkoglu, Banu Mansuroglu
doaj +1 more source