Results 11 to 20 of about 508 (143)

Defining regorafenib as a senomorphic drug: therapeutic potential in the age-related lung disease emphysema

Experimental and Molecular Medicine, 2023
Senescence, a hallmark of aging, is a factor in age-related diseases (ARDs). Therefore, targeting senescence is widely regarded as a practicable method for modulating the effects of aging and ARDs.
Jung-Jin Park, Kwangseok Oh, Gun-Wu Lee, Geul Bang, Jin-Hee Park, Han-Byeol Kim, Jin Young Kim, Eun-Young Shin, Eung-Gook Kim   +8 more
doaj   +4 more sources

Frentizole derivatives with mTOR inhibiting and senomorphic properties [PDF]

Biomedicine & Pharmacotherapy, 2023
Frentizole is immunosuppressive drug with low acute toxicity and lifespan-prolonging effect. Recently, frentizole´s potential to disrupt toxic amyloid β (Aβ) - Aβ-binding alcohol dehydrogenase (ABAD) interaction in mitochondria in Alzheimer´s brains has ...
Kristina Holubova, Milovanović, Zoran, Andrys, Rudolf, Dumanović, Jelena, Zoran Milovanovic, Klaudia Jomova, Josef Novak, Oleksak, Patrik, Holubova, Kristina, Franca, Tanos C. C., Vales, Karel, Pavla Vasicova, Chrienova, Zofia, Tanos C.C. Franca, Botelho, Fernanda D., Adam Skarka, Skoupilova, Veronika, Jomova, Klaudia, Fernanda D. Botelho, Kamil Kuca, Veronika Skoupilova, Vesna Jacevic, Marketa Chvojkova, Eugenie Nepovimova, Zdenek Hodny, Chvojkova, Marketa, Alomar, Suliman Y., Patrik Oleksak, Hodny, Zdenek, Suliman Y. Alomar, Valko, Marian, Kuca, Kamil, Skarka, Adam, Vasicova, Pavla, Zofia Chrienova, David Rysanek, Rudolf Andrys, Rysanek, David, Jaćević, Vesna, Karel Vales, Novak, Josef, Nepovimova, Eugenie, Marian Valko, Jelena Dumanovic   +43 more
core   +5 more sources

Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect

International Journal of Molecular Sciences
Cellular senescence is closely connected with cancer progression, recurrence, and metastasis. Senotherapy aims to soothe the harmful effects of senescent cells either by inducing their apoptosis (senolytic) or by suppressing the senescence-associated ...
Olena Ivashchenko, Agata Henschke, Bartosz Grześkowiak, María Celina Sánchez-Cerviño, Emerson Coy, Sergio Moya   +5 more
core   +5 more sources

Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

Scientific Reports
Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging.
Patrick Bogdanowicz, Paul Bensadoun, Maïté Noizet, Benoît Béganton, Armony Philippe, Sandrine Alvarez-Georges, Gautier Doat, Amélie Tourette, Sandrine Bessou-Touya, Jean-Marc Lemaitre, Hélène Duplan   +10 more
doaj   +2 more sources

The Senotherapeutic Effects of APPA (Apocynin [AP] and Paeonol [PA]) on Senescent Human Chondrocytes

Pharmaceuticals
Background/Objectives: Osteoarthritis (OA) is a complex joint disease involving chronic inflammation, aging, and obesity, affecting nearly 6 million people worldwide.
Mercedes Fernández-Moreno, Tamara Hermida-Gómez, Carlos Vaamonde-Garcia, Sara Paniagua-Barro, Nicholas Larkins, Alan Reynolds, Francisco J. Blanco   +6 more
doaj   +2 more sources

Targeting SASP with FDA-approved agents: minoxidil and diazoxide as potential senomorphic agents in cancer therapy

Türk Biyokimya Dergisi
Chemotherapy-induced senescent cells are recognized to lead to cancer progression and resistance to treatment by releasing factors associated with the senescence-associated secretory phenotype (SASP).
Simay Demir Yaprak Dilber, Mohammed Ahmed Islam, Tayyar Tugce, Ozdemir Aysun, Ark Mustafa   +4 more
doaj   +2 more sources

Targeting cellular senescence with senotherapeutics: senolytics and senomorphics [PDF]

The FEBS Journal, 2022
The concept of geroscience is that since ageing is the greatest risk factor for many diseases and conditions, targeting the ageing process itself will have the greatest impact on human health. Of the hallmarks of ageing, cellular senescence has emerged as a druggable therapeutic target for extending healthspan in model organisms. Cellular senescence is
Lei Zhang, Louise E. Pitcher, Vaishali Prahalad, Laura J. Niedernhofer, Paul D. Robbins   +4 more
openaire   +2 more sources

HSP90 acts as a senomorphic target in senescent retinal pigmental epithelial cells [PDF]

Aging, 2021
The senescence of retinal pigment epithelial (RPE) cells is associated with age-related macular degeneration (AMD), a leading cause of blindness in the world. HSP90 is a predominant chaperone that regulates cellular homeostasis under divergent physio-pathological conditions including senescence.
Chen, Dan-Dan, Peng, Xuyan, Wang, Yuxuan, Jiang, Mingjun, Xue, Mengjiao, Shang, Guohui, Liu, Xuhui, Jia, Xiaolin, Liu, Baixue, Lu, Yingwei, Mu, Hongmei, Zhang, Fengyan, Hu, Yanzhong   +12 more
openaire   +2 more sources

PGC1α‐Inducing Senomorphic Nanotherapeutics Functionalized with NKG2D‐Overexpressing Cell Membranes for Intervertebral Disc Degeneration

Advanced Science
Cellular senescence is a significant contributor to intervertebral disc aging and degeneration. However, the application of senotherapies, such as senomorphics targeting senescence markers and the senescence‐associated secretory phenotype (SASP), remains
Sheng Liu, Kanglu Li, Yuxin He, Sheng Chen, Wenbo Yang, Xuanzuo Chen, Shiqing Feng, Liming Xiong, Yizhong Peng, Zengwu Shao   +9 more
doaj   +3 more sources

The senomorphic impact of astaxanthin on irradiated rat spleen: STING, TLR4 and mTOR contributed pathway

International Journal of Immunopathology and Pharmacology
Objectives: Exposure of spleen tissues to ionizing radiation during radiotherapy can induce cellular stress and immune-dysfunction leading to cellular senescence.
Maha M Aziz, Marwa M El-Sheikh, Marwa A Mohamed, Sahar S Abdelrahman, Mai H Mekkawy   +4 more
doaj   +3 more sources