Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar +10 more
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Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy [PDF]
Aging CellABSTRACT Senescent cells are known to contribute to aging and age‐related diseases. One key way they influence aging is by secreting senescence‐associated secretory phenotype (SASP) factors along with several damage‐associated molecular pattern (DAMP) molecules.
Julie K Andersen, Amit Sharma
exaly +5 more sources
Identification of Senomorphic miRNAs in Embryonic Progenitor and Adult Stem Cell‐Derived Extracellular Vesicles [PDF]
Aging CellABSTRACT Extracellular vesicles (EVs) are secreted by most cell types, transmitting crucial signaling molecules like proteins, small RNAs, and DNA. We previously demonstrated that EVs from murine and human mesenchymal stem cells (MSCs) functioned as senomorphics to suppress markers of senescence and the ...
Luise Angelini +2 more
exaly +4 more sources
The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases [PDF]
BiomedicinesCellular senescence is a permanent cell cycle arrest that plays a critical role in the development and pathogenesis of age-related diseases. This paper aims to present the biological mechanisms of cellular senescence and the role of the senescence ...
Zuzanna Krupa +9 more
doaj +2 more sources
Frontiers in Neurology, 2023 Drosophila melanogaster is a valuable model organism for a wide range of biological exploration. The well-known advantages of D. melanogaster include its relatively simple biology, the ease with which it is genetically modified, the relatively low ...
Sean J. Miller +4 more
doaj +3 more sources
The Senotherapeutic Effects of APPA (Apocynin [AP] and Paeonol [PA]) on Senescent Human Chondrocytes [PDF]
PharmaceuticalsBackground/Objectives: Osteoarthritis (OA) is a complex joint disease involving chronic inflammation, aging, and obesity, affecting nearly 6 million people worldwide.
Mercedes Fernández-Moreno +6 more
doaj +2 more sources
The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases [PDF]
Nature CommunicationsAging is a primary risk factor for chronic diseases, with cellular senescence as an effective target to delay, prevent or alleviate age-related disorders.
Qixia Xu +9 more
doaj +2 more sources
Scientific ReportsIntrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging.
Patrick Bogdanowicz +10 more
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Integrative Approaches to Treating Cellular Senescence in Kidney Disease [PDF]
Advanced ScienceCellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in ...
Tomoka Misawa +3 more
doaj +2 more sources
Novel therapeutic strategies for osteoarthritis: from mechanistic insights to precision medicine [PDF]
Bone ResearchOsteoarthritis (OA) is a prevalent chronic degenerative joint disease that significantly impacts the quality of life for over 500 million individuals affected.
Muhammad Umar +6 more
doaj +2 more sources