Results 81 to 90 of about 1,245 (145)
Cell RegenerationThe COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu +7 more
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The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies
BiomedicinesThe impressive achievements made in the last century in extending the lifespan have led to a significant growth rate of elderly individuals in populations across the world and an exponential increase in the incidence of age-related conditions such as ...
Vharoon Sharma Nunkoo +4 more
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Advanced ScienceThe pursuit of pharmacological interventions in aging aims focuses on maximizing safety and efficacy, prompting an exploration of natural products endowed with inherent medicinal properties.
Jiqun Wang +11 more
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Proceedings of the National Academy of SciencesIncreased cellular senescence burden contributes in part to age-related organ dysfunction and pathologies. In our study, using mouse models of natural aging, we observed structural and functional decline in the aged retina, which was accompanied by the accumulation of senescent cells and senescence-associated secretory phenotype factors.
Yidan Liu +13 more
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Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity
Frontiers in Bioscience-LandmarkAgeing is a progressive functional decline in health conditions and a risk factor for many chronic diseases. To address the elevated burden of age-related pathologies, the ageing process has been extensively studied over the past decades, and yet the ...
Afsar U. Ahmed
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Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities
Frontiers in Cell and Developmental BiologyLens epithelial cells (LECs) senescence is a central pathogenic mechanism in cataract formation, driven by a variety of chronic stressors such as oxidative damage, UV radiation, metabolic disturbances, and mechanical strain.
Liangning Cui +7 more
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TargetsTaken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Hejing Tang +12 more
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Deruxtecan-based antibody–drug-conjugates induce senescence in HER2-positive breast cancer
Scientific ReportsBreast cancer (BrCa) represents one of the most common malignancies and the leading cause of cancer-related deaths in women worldwide. Despite the advances in therapeutic treatments, de novo and/or acquired resistance still represents a major clinical ...
Elena Vezzoli +14 more
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Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines
Abstract Cellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP).
Hongwei Zhang +7 more
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Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti-Wrinkle Efficacy. [PDF]
J Cosmet DermatolRadić B, Šuran J.
europepmc +1 more source