Results 81 to 90 of about 508 (143)
Stress-dependent senomorphic-like activity of buckwheat-derived rutin mediated via SIRT1
Sirtuin 1 (SIRT1) is a key NAD⁺-dependent deacetylase regulating cellular metabolism, oxidative stress resistance, and longevity. This study investigates the senomorphic-like effects of buckwheat-derived rutin on SIRT1 under basal and toxic stress ...
N. Hamzaeva
core +1 more source
Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley +1 more source
Nature CommunicationsSenescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang +14 more
doaj +1 more source
Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke
PharmaceuticalsAging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier +2 more
doaj +1 more source
Screening for senolytic and senomorphic compounds in HDF76 fibroblasts and their effects as geroprotectors in C. elegans [PDF]
El envejecimiento es el principal factor de riesgo para muchas enfermedades, y la senescencia celular es un factor clave en este proceso y sus patologías relacionadas.
Sanguinet Rumayor, Sybila
core
Treating Senescence like Cancer: Novel Perspectives in Senotherapy of Chronic Diseases
, 2020 The WHO estimated around 41 million deaths worldwide each year for age-related non-communicable chronic diseases. Hence, developing strategies to control the accumulation of cell senescence in living organisms and the overall aging process is an urgently
Antonella Farsetti +6 more
core +1 more source
Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice
FEBS Open BioSARS‐CoV‐2 infection can lead to severe COVID‐19, particularly in elderly individuals and those with compromised immunity. Cellular senescence has been implicated as a key pathogenic mechanism.
Ju Hwan Jeong +5 more
doaj +1 more source
The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications
Experimental GerontologyOsteoarthritis (OA) is a common and debilitating joint disorder, with its pathogenesis significantly influenced by factors such as aging and obesity.
Kai Huang, Haili Cai
doaj +1 more source
Communications BiologyStudy of cellular senescence is critical in aging research and anti-senescence therapy drug development. Current methods for the evaluation of the widely accepted cellular senescence marker senescence-associated beta galactosidase (SA-β-gal) activity ...
Yajie Hu +6 more
doaj +1 more source
SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY
Central Asian Journal of Medical Hypotheses and EthicsAging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related diseases. Targeting cellular senescence has emerged as a novel therapeutic paradigm in geroscience.
Timur Saliev, Prim B. Singh
openaire +1 more source