Results 81 to 90 of about 1,609 (186)

Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice

Advanced Science
Cellular senescence is a cell fate triggered by stressful stimuli and displays a hypersecretory feature, the senescence‐associated secretory phenotype (SASP). Senescent cell burden increases with aging and contributes to age‐related organ dysfunction and
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun   +10 more
doaj   +1 more source

Identification of gingerenone A as a novel senolytic compound.

PLoS ONE, 2022
Senescent cells accumulate with aging and have been shown to contribute to age-associated diseases and organ dysfunction. Eliminating senescent cells with senolytic drugs has been shown to improve age phenotypes in mouse models and there is some initial ...
Ruin Moaddel, Martina Rossi, Stephanie Rodriguez, Rachel Munk, Mohammed Khadeer, Kotb Abdelmohsen, Myriam Gorospe, Luigi Ferrucci   +7 more
doaj   +1 more source

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP). [PDF]

Accumulation of DNA damage can accelerate aging through cellular senescence. Previously, we established a Drosophila model to investigate the effects of radiation-induced DNA damage on the intestine.
Bar, Sudipta, Basisty, Nathan, Bons, Joanna, Campisi, Judith, Hilsabeck, Tyler A U, Kapahi, Pankaj, López-Domínguez, José Alberto, Pattavina, B, Schilling, Birgit, Sharma, Amit, Watson, Mark   +10 more
core   +2 more sources

Morphofunctional Heterogeneity and Plasticity of Glioblastoma Cells Induced to Senescence by Temozolomide

Aging Cell, Volume 25, Issue 4, April 2026.
Glioblastoma cells induced to senescence by Temozolomide are heterogeneous, with the emergence of two main states, named E‐state and F‐state, which differ in cellular morphometry, survival mechanisms, and sensitivity to autophagy modulators and senolytics. These states are dynamic, with the occurrence of morphofunctional transitions.
Solon Andrades da Rosa, Henrique Quaiato de Oliveira, Laura Boose de Mendonça, Nicole Borgmann de Oliveira, Mariane da Cunha Jaeger, Luiza Cherobini Pereira, Fernanda Dittrich Pinto Oliveira, Debora Santos‐Sousa, Fernanda Saez‐Calazans, Luana Lenz, Melike Lakadamyali, Guido Lenz, Eduardo Cremonese Filippi‐Chiela   +12 more
wiley   +1 more source

Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging

Scientific Reports
Intrinsic and extrinsic factors, including lifestyle and sun exposure, can contribute to cell senescence, which impairs skin homeostasis, that may in turn lead to skin aging.
Patrick Bogdanowicz, Paul Bensadoun, Maïté Noizet, Benoît Béganton, Armony Philippe, Sandrine Alvarez-Georges, Gautier Doat, Amélie Tourette, Sandrine Bessou-Touya, Jean-Marc Lemaitre, Hélène Duplan   +10 more
doaj   +1 more source

Cell Type‐Specific Expression of p16, p21, and p53 Reveals Age‐Dependent Glial Senescence in the AppNL‐G‐F Mouse Model of Alzheimer's Disease

Aging Cell, Volume 25, Issue 4, April 2026.
Longitudinal senescence profiling in AppNL‐G‐F Alzheimer's mice reveals progressive microglial and astrocytic senescence (p16/p21 upregulation, morphological impairment, SA‐β‐galactosidase activity, and elevated IL‐1β and IL‐6) without neuronal senescence.
Eileen Mac Sweeney, Giulia Abate, Bjorn R. V. Bakker, Andrea Mastinu, Ylenia Lai, Daniela Uberti, Per Nilsson, Simone Tambaro   +7 more
wiley   +1 more source

Screening for senolytic and senomorphic compounds in HDF76 fibroblasts and their effects as geroprotectors in C. elegans [PDF]

El envejecimiento es el principal factor de riesgo para muchas enfermedades, y la senescencia celular es un factor clave en este proceso y sus patologías relacionadas.
Sanguinet Rumayor, Sybila
core  

Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies [PDF]

Aging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated disorders.
Fu, Tianlu Esther, Zhou, Zhongjun
core   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, Volume 13, Issue 13, 3 March 2026.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

ROS‐Responsive Wedelolactone Hydrogel Promotes Intervertebral Disc Repair by Disrupting the NF‐κB–LCN2 Inflammatory Feedback Loop

Advanced Science, Volume 13, Issue 14, 9 March 2026.
A mechanically robust, ROS‐responsive hydrogel is engineered to treat intervertebral disc degeneration by targeting the NF‐κB–LCN2 inflammatory feedback loop. By delivering wedelolactone specifically within oxidative niches, this system disrupts macrophage–disc cell crosstalk.
Zimei Wu, Yan Xu, Lang Qin, Zemin Ling, Yingjie Mai, Xiong Tian Guo, Jiajia Chen, Leping Yan, Lin Wang, Liming Bian, Fuxin Wei   +10 more
wiley   +1 more source