Results 91 to 100 of about 508 (143)

Royal jelly suppresses senescence-associated secretory phenotype in senescent human epidermal keratinocytes

Background Royal Jelly (RJ) is widely used in cosmetics for its beneficial skin effects, but its impact on cellular senescence remains unclear.
Yukie Nakagawa, Hideto Okamoto, Nobuaki Okumura   +2 more
core   +1 more source

Defining Microbiota‐Derived Metabolite Butyrate as a Senomorphic:Therapeutic Potential in the Age‐Related T Cell Senescence [PDF]

Advancing age is accompanied by an accumulation of senescent T cells that secrete pro‐inflammatory senescence‐associated secretory phenotype (SASP) molecules. Gut‐microbiota‐derived signals are increasingly recognised as immunomodulators.
Conway, Jessica; id_orcid, Duggal, Niharika A.; id_orcid, Rees, Nia Paddison, Carding, Simon R., Parker, Aimee, Dugan, Ben, Amir, Sayeda S.   +6 more
core   +1 more source

Novel therapeutic strategies for osteoarthritis: from mechanistic insights to precision medicine

Bone Research
Osteoarthritis (OA) is a prevalent chronic degenerative joint disease that significantly impacts the quality of life for over 500 million individuals affected.
Muhammad Umar, Ziling Wang, Jingwen Li, Zhen Li, Gang Li, Liping Tong, Di Chen   +6 more
doaj   +1 more source

Targeting senescence induced by age or chemotherapy with a polyphenol-rich natural extract improves longevity and healthspan in mice [PDF]

Accumulating senescent cells within tissues contribute to the progression of aging and age-related diseases. Botanical extracts, rich in phytoconstituents, present a useful resource for discovering therapies that could target senescence and thus improve ...
Scanu, Anna, Pellegrini, Laura, Iaccarino, Luca, Sharifi, Saman, Fassan, Matteo, Colucci, Manuel, Barile, Lucio, Sgrignani, Jacopo, Valdata, Aurora, Auwerx, Johan, Alimonti, Andrea, Zumerle, Sara, Sabbadin, Marianna, Bolis, Marco, Peron, Gregorio, Altomare, Claudia, Masiero, Stefano, Mosole, Simone, Giori, Andrea Maria, Sandri, Marco, Cippà, Pietro, Cavalli, Andrea, Sarill, Miles, Sartori, Roberta, Dall’Acqua, Stefano, Torcasio, Cristina, Giacomini, Isabella, Pezzini, Camilla, Rizzo, Beatrice, Bressan, Silvia, Rinaldi, Andrea, Saponaro, Miriam, Brina, Daniela, Pierantoni, Alessandra, Pasquini, Emiliano, Lazzarini, Edoardo, Locatelli, Patrizia, Luisetto, Roberto, Goshovska, Yulia, Contu, Liliana, Giraudo, Chiara, Rinaldi, Anna, Dall'Acqua, Stefano, Montopoli, Monica   +43 more
core   +1 more source

Apigenin and Phloretin Combination for Skin Aging and Hyperpigmentation Regulation

Cosmetics
Melasma is a pathology with multifactorial causes that results in hyperpigmentation of sun-exposed areas, particularly facial skin. New treatments targeting the different factors regulating this condition need to be effective with and have limited ...
Alfredo Martínez-Gutiérrez, Javier Sendros, Teresa Noya, Mari Carmen González   +3 more
doaj   +1 more source

Mechanisms underlying senotherapeutic potential of HSP90 inhibition in human cells

The twelve recently identified hallmarks of ageing are not completely independent of one another and it is important to have a better understanding of the interactions between them.

core   +2 more sources

The Role of Cellular Senescence and SASP in the Pathogenesis of Atherosclerosis and the Therapeutic Potential of Senolytic Strategies in Cardiovascular Diseases

Biomedicines
Cellular senescence is a permanent cell cycle arrest that plays a critical role in the development and pathogenesis of age-related diseases. This paper aims to present the biological mechanisms of cellular senescence and the role of the senescence ...
Zuzanna Krupa, Joanna Wrona, Marta Zawadzka, Julia Rydzek, Julia Lizon, Paulina Kalemba, Konrad Kochman, Paweł Iwaszkiewicz, Robert Iwanowski, Sławomir Woźniak   +9 more
doaj   +1 more source

Immunocyte senescence: A new perspective on the remodeling of the ovarian cancer microenvironment and therapeutic intervention

Journal of Pharmaceutical Analysis
Immune cell senescence in ovarian cancer manifests as distinct phenotypic alterations in T cells, natural killer (NK) cells, macrophages, and dendritic cells (DCs), alongside dynamic crosstalk with the tumor microenvironment (TME).
Xiang Li, Xian Li, Sha Ni, Xiaohui Zhang, Bingnan Liu   +4 more
doaj   +1 more source

The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies

Biomedicines
The impressive achievements made in the last century in extending the lifespan have led to a significant growth rate of elderly individuals in populations across the world and an exponential increase in the incidence of age-related conditions such as ...
Vharoon Sharma Nunkoo, Alexander Cristian, Anamaria Jurcau, Razvan Gabriel Diaconu, Maria Carolina Jurcau   +4 more
doaj   +1 more source

Precious-3 GPT: Supplementary materials

Supplementary materials to the bioRxiv preprint of Precious-3 GPT — a multi-modal multi-omics multi-species LLM Table S1 — Clinical target genes overlapping with P3GPT gene lists obtained with next-token generation for simulated medical conditions ...
Fedor Galkin
core   +1 more source