The role of p21 in cellular senescence and aging-related diseases
Molecules and Cells: During the aging process or disease progression, normal cells and tissues in the body undergo various stresses, leading to cell damage and the need for repair, adaptation, apoptosis, or defense responses.
Jiayu Yan +6 more
doaj +1 more source
Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging [PDF]
Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA) and its byproduct, phenylacetylglutamine (
Alimonti, Andrea +20 more
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Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, Volume 13, Issue 14, 9 March 2026.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
Aging and Senotherapeutics [PDF]
, 2019 One of the key mechanisms of the aging process of an organism and of the dysfunctionality and chronic diseases related with aging is the so-called cell senescence.
Ivana Čepelak, Slavica Dodig
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MedComm – Oncology, Volume 5, Issue 1, March 2026.Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang +7 more
wiley +1 more source
Editorial: Cellular senescence in physiology and pathophysiology
Frontiers in Physiology, 2023 Mustafa Ark, Mohammad Nasir Uddin
doaj +1 more source
Divergent regulation of long non-coding RNAs H19 and PURPL affects cell senescence in human dermal fibroblasts. [PDF]
Cellular senescence is a permanent cell growth arrest that occurs in response to various intrinsic and extrinsic stimuli and is associated with cellular and molecular changes.
Anceschi, C +11 more
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Fibrates as drugs with senolytic and autophagic activity for osteoarthritis therapy [PDF]
, 2019 Research paper[Abstract] Background. Ageing-related failure of homeostasis mechanisms contributes to articular cartilage degeneration and osteoarthritis (OA), for which disease-modifying treatments are not available.
Blanco García, Francisco J +10 more
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Gene therapy for fat-1 prevents obesity-induced metabolic dysfunction, cellular senescence, and osteoarthritis [PDF]
Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) composition.
Choi, Yun-Rak +6 more
core +2 more sources
Regorafenib as a potential drug for severe COVID‐19: inhibition of inflammasome activation in mice
FEBS Open BioSARS‐CoV‐2 infection can lead to severe COVID‐19, particularly in elderly individuals and those with compromised immunity. Cellular senescence has been implicated as a key pathogenic mechanism.
Ju Hwan Jeong +5 more
doaj +1 more source