Senescence and SASP Are Potential Therapeutic Targets for Ischemic Stroke
PharmaceuticalsAging is a known co-morbidity of ischemic stroke with its risk and severity increasing every year past 55+. While many of the current stroke therapies have shown success in reducing mortality, post-stroke morbidity has not seen the same substantial ...
Blake Ouvrier +2 more
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TargetsTaken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Hejing Tang +12 more
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SENOLYTICS AND SENOMORPHICS: A NEW CLASS OF DRUGS FOR ANTI-AGING THERAPY
Central Asian Journal of Medical Hypotheses and EthicsAging is a complex biological process characterized by the accumulation of senescent cells that adopt a senescence-associated secretory phenotype (SASP), releasing proinflammatory mediators that drive tissue dysfunction and the onset of age-related diseases. Targeting cellular senescence has emerged as a novel therapeutic paradigm in geroscience.
Timur Saliev, Prim B. Singh
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Nature CommunicationsSenescence-associated secretory phenotype (SASP) mediates the biological effects of senescent cells on the tissue microenvironment and contributes to ageing-associated disease progression.
Li Yang +14 more
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The role of chondrocyte senescence in osteoarthritis pathogenesis and therapeutic implications
Experimental GerontologyOsteoarthritis (OA) is a common and debilitating joint disorder, with its pathogenesis significantly influenced by factors such as aging and obesity.
Kai Huang, Haili Cai
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Viscosupplementation and Synovial Fluid Rheology: A Hidden Risk for Bacterial Biofilm Formation in Joint Infections? [PDF]
Synovial fluid (SF) plays a critical role in joint lubrication, load distribution, and maintaining homeostasis within the synovial cavity. Its rheological properties, primarily influenced by hyaluronic acid (HA) and other macromolecules, are essential ...
Fabiana Giarritiello +2 more
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Apigenin and Phloretin Combination for Skin Aging and Hyperpigmentation Regulation
CosmeticsMelasma is a pathology with multifactorial causes that results in hyperpigmentation of sun-exposed areas, particularly facial skin. New treatments targeting the different factors regulating this condition need to be effective with and have limited ...
Alfredo Martínez-Gutiérrez +3 more
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Targeting senescence in Lymphangioleyomyomatosis through senomorphic-like molecules as a paradigm to counteract senescence in lung tumor microenvironment [PDF]
Lymphangioleiomyomatosis (LAM) is a pulmonary low-grade, destructive, metastasizing rare neoplasm occurring in young women as a sporadic disorder or in association with tuberous sclerosis complex (TSC, LAM/TSC).
Bernardelli C. +8 more
core
Revolutionizing Aging: The Dawn of Longevity Medicine and Lifespan Extension [PDF]
Ageing, conventionally measured as an inevitable biological process, is one of the major areas of leading-edge scientific research. Nowadays, the field of senolytics, telomere extension and other cellular rejuvenation techniques intended at tackling ...
Irfan, Asma
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The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies
BiomedicinesThe impressive achievements made in the last century in extending the lifespan have led to a significant growth rate of elderly individuals in populations across the world and an exponential increase in the incidence of age-related conditions such as ...
Vharoon Sharma Nunkoo +4 more
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