Results 101 to 110 of about 508 (143)

Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells

Targets
Taken together, cardiovascular diseases (CVDs) have become one of the prime causes of the global disease burden. Aging is closely related to CVDs and is considered to be one of the crucial factors in the incidence of CVDs. In the process of aging, cellular senescence is an important cause of CVDs such as atherosclerosis and atrial fibrillation.
Hejing Tang, Xu Zhang, Senyang Hu, Yuhan Song, Wenhua Jin, Jianmin Zou, Yan Zhang, Jiayue Guo, Peng An, Junjie Luo, Pengjie Wang, Yongting Luo, Yinhua Zhu   +12 more
openaire   +1 more source

Targeting senescent cells in aging and COVID-19: from cellular mechanisms to therapeutic opportunities

Cell Regeneration
The COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu, Kaixuan Lin, Haoyu Wu, Mingli Hu, Xuejie Yang, Jie Wang, Johannes Grillari, Jiekai Chen   +7 more
doaj   +1 more source

Targeting senescence in Lymphangioleyomyomatosis through senomorphic-like molecules as a paradigm to counteract senescence in lung tumor microenvironment [PDF]

Lymphangioleiomyomatosis (LAM) is a pulmonary low-grade, destructive, metastasizing rare neoplasm occurring in young women as a sporadic disorder or in association with tuberous sclerosis complex (TSC, LAM/TSC).
Taci E., Gervasini C., Lesma E., Bernardelli C., Cappello G., Selvaggio P., Di Fede E., Rosa S., Massa V.   +8 more
core  

FOXM1 및 E2F1 활성화를 통한 세포 노화 회복 효과

Aging, Cellular senescence, Synergism, senomorphic effect, FOXM1, E2F1.Age-associated cellular senescence is characterized by cessation of cell division. However, the molecular pathways underlying cell cycle reactivation in senescent cells remain elusive,
Eun Jae Yang
core   +1 more source

Development of nanoparticles loaded with D-mannose for topical treatment to alleviate skin aging via rescuing SIRT1 from degradation

Materials Today Bio
Skin aging is a complicated biological process, greatly interrupting skin physical function and increasing the risk of aging-associated skin diseases, therefore, drugs or treatment to delay or even reverse this process is in urgent need.
Jialiang Luo, Weijie Shao, Shuai Liu, Zhicheng Liang, Xiaojing Dong, Shidian Xu, Honghao Hou, Daming Zuo, Jia Zhou   +8 more
doaj   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science
Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in ...
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
doaj   +1 more source

In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects

Cancer Cell International
Background Cellular senescence is a stress-induced state characterized by irreversible cell cycle arrest. Senescent cells accumulate during aging and contribute to age-related diseases, including neurodegeneration, cancer, and type 2 diabetes mellitus ...
David Rysanek, Zofia Chrienova, Dorota Stary, Marek Bajda, Josef Novak, Pavla Vasicova, Jirina Kroupova, Rudolf Andrys, Adam Skarka, Erika Rousarova, Jan Capek, Tomas Rousar, Zoran Milovanovic, Jelica Grujic-Milanovic, Vesna Jacevic, Jayaprakash N. Kolla, Martin Popr, Dominika Maurencova, Patrik Oleksak, Lukas Fresser, Kamil Kuca, Zdenek Hodny, Eugenie Nepovimova   +22 more
doaj   +1 more source

Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines

Abstract Cellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP).
Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Sanhong Liu, James L. kirkland, Weidong Zhang, Yu Sun   +7 more
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老化細胞阻害(senomorphic)薬

Farumashia, 2020
ISHII, Takamasa, YASUDA, Kayo
openaire   +1 more source

Targeting cellular senescence in dermatology: senolytic and senomorphic strategies

GeroScience
Diala Haykal, Frederic Flament, Lilit Garibyan, Kachiu Lee, Julie Escot, Audrey Gueniche, James Kirkland   +6 more
openaire   +1 more source