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Free Radical Biology and Medicine, 2021
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Lagoumtzi, Sofia M, Chondrogianni, Niki
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Cellular senescence is a heterogeneous process guided by genetic, epigenetic and environmental factors, characterizing many types of somatic cells. It has been suggested as an aging hallmark that is believed to contribute to aging and chronic diseases.
Lagoumtzi, Sofia M, Chondrogianni, Niki
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Senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction
2023The accumulation of senescent cells in the aging individual is associated with an increase in the occurrence of age-associated pathologies that contribute to poor health, frailty, and mortality. The number and type of senescent cells is viewed as a contributor to the body's senescence burden.
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Senomorphic properties of miR-181b in aged human aortic smooth muscle cells
Physiology, 2023Introduction: Age associated large artery stiffness (LAS) is an independent predictor of adverse cardiovascular health outcomes in humans and has also been shown to be associated with the development of heart failure, kidney disease, and even dementia.
Denisse Moreno +5 more
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Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy
Aging CellAbstract Senescent cells are known to contribute to aging and age-related diseases. One key way they influence aging is by secreting senescence-associated secretory phenotype (SASP) factors along with several damage-associated molecular pattern (DAMP) molecules. Consequently, inhibiting SASP and DAMP signaling (senomorphics) has emerged
Anna Barkovskaya +5 more
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HYDROCHLOROTHIAZIDE AS A NEW SENOMORPHIC DRUG CANDIDATE
Amaç: Konvansiyonel kanser tedavisinde kullanılan kemoterapötiklerin hem kanser hem de kanser olmayan hücrelerde hücresel senesensi indüklediği bilinmektedir. Senesent hücrelerin önemli özellikleri, hücre morfolojilerinde belirgin değişikliklerin olması ve bu hücrelerden senesens ilişkili sekretuvar fenotip (SASP) olarak adlandırılan çeşitli sitokin ...Şimay Demir, Yaprak Dilber +1 more
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Current Topics in Medicinal Chemistry
Aging is an inevitable biological process characterized by a progressive decline in physiological functions, increased vulnerability to disease, and ultimately death. While aging is influenced by genetic, environmental, and lifestyle factors, accumulating evidence indicates that cellular senescence is a central
Seshathri Pandurangan +3 more
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Aging is an inevitable biological process characterized by a progressive decline in physiological functions, increased vulnerability to disease, and ultimately death. While aging is influenced by genetic, environmental, and lifestyle factors, accumulating evidence indicates that cellular senescence is a central
Seshathri Pandurangan +3 more
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Targeting Senescence-Inducing Vesicles: The Endomembrane System as a Senomorphic Avenue
Secreted molecules as cytokines, chemokines, grow factors and the release of small extracellular vesicles (sEV) modulate the cellular microenvironment. Senescent cells main characteristics are the inhibition of the cell cycle, an increased β-galactosidase activity and a specific secretome of the previous compounds known as Senescence Associated ...Lucio-Gallego, Sergio +7 more
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Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin
Science Advances, 2021Chris Harman +2 more
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