Results 121 to 130 of about 1,609 (186)

Rapamycin exerts its geroprotective effects in the ageing human immune system by enhancing resilience against DNA damage [PDF]

mTOR inhibitors such as rapamycin are among the most robust life-extending interventions known, yet the mechanisms underlying their geroprotective effects in humans remain incompletely understood.
Alsaleh, Ghada, Atherton, Philip J, Cox, Lynne S, Gharahdaghi, Nima, Jones, Eleanor J, Kell, Loren, Simon, Anna K, Smith, Kenneth, Wilkinson, Daniel J   +8 more
core   +2 more sources

Synergistic targeting of senolytic and senomorphic action with dual-engineered biomimetic macrophage nanovesicles for mitigating osteoarthritis

Bioactive Materials
Osteoarthritis (OA), a leading cause of chronic disability worldwide, is increasingly recognized to be driven by the accumulation of senescent chondrocytes (sCDs) and their deleterious pro-inflammatory senescence-associated secretory phenotype (SASP ...
Wenan Peng, Ziming Wang, Zenan Zhuang, Simin Zeng, Yu Xia, Qiwen Chen, Xuan Bai, Ying Tang, Cui Huang, Xianzheng Zhang   +9 more
doaj   +1 more source

The natural flavonoid dihydromyricetin targets senescent cells via PRDX2 and alleviates age-related diseases

Nature Communications
Aging is a primary risk factor for chronic diseases, with cellular senescence as an effective target to delay, prevent or alleviate age-related disorders.
Qixia Xu, Gaoxiang Li, Hongwei Zhang, Zhirui Jiang, Xiuxia Gao, Zi Li, Larissa G. P. Langhi Prata, James L. Kirkland, Guilong Zhang, Yu Sun   +9 more
doaj   +1 more source

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Metabolites
Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Eleni Mavrogonatou, Dimitris Kletsas
doaj   +1 more source

Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease [PDF]

Cardiovascular diseases (CVDs), a group of disorders affecting the heart or blood vessels, are the primary cause of death worldwide, with an immense impact on patient quality of life and disability.
Booth LK, Camacho-Encina M, Folaranmi O, Redgrave RE, Richardson DG, Spyridopoulos I   +5 more
core  

The impacts of chronic infections on shaping cellular senescence

Immunity & Ageing
Cellular senescence is a fundamental biological process characterized by stable cell cycle arrest, genomic instability, and the acquisition of a proinflammatory secretory phenotype.
Ashley Johnson, Troy Rought, Jacob Aronov, Princess Pokharel, Angelina Chiu, Azadeh Nasuhidehnavi   +5 more
doaj   +1 more source

Investigating the potential senomorphic properties of SCFA butyrate on aged T cells. [PDF]

Ageing is accompanied by remodelling of the T cell pool and a hallmark of immune ageing is the expansion of senescent T cells in aged hosts. Senescent T cells express markers of DNA damage and cell cycle arrest markers, elevated production of pro ...
Paddison Rees, Nia
core  

Senomorphic Activity of a Novel Standardized Propolis Extract in Human Dermal Fibroblasts: Molecular Insights Into Clinically Proven Anti-Wrinkle Efficacy. [PDF]

J Cosmet Dermatol
Radić B, Šuran J.
europepmc   +1 more source

Impairment of Macrophage Functions by the Senescence-Associated Secretory Phenotype of Vascular Smooth Muscle Cells-Brief Report. [PDF]

Arterioscler Thromb Vasc Biol
Tsitsipatis D, Rodriguez Rivera T, Kaileh M, Okereke AN, Gupta A, Singh A, Raph SM, Henry-Smith C, Herman AB.   +8 more
europepmc   +1 more source

Natural killer cell-based senotherapy: a promising strategy for healthy aging. [PDF]

Front Immunol
Nakazawa T, Yamanishi R, Morimoto T, Matusda R.   +3 more
europepmc   +1 more source