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AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent

aging and disease
Assessing impact on the hallmarks of aging has emerged as a novel method for prioritizing dual-purpose longevity therapeutic targets and developing drugs simultaneously targeting aging and disease. Cellular senescence, a central hallmark of aging, progressively induces cellular growth arrest and accelerates the production of a pro-inflammatory ...
Tang, Qiuqiong, Xiao, Deyong, Veviorskiy, Alexander, Xin, Ying, Lok, Sarah W.Y., Pulous, Fadi E., Zhang, Peiran, Zhu, Yunfeng, Ma, Yongming, Hu, Xiao, Gu, Shoulai, Zong, Chenting, Mukba, Sabina, Korzinkin, Mikhail, Pun, Frank W., Zhang, Man, Aliper, Alex, Wu, Lijuan, Ren, Feng, Zhang, Li, Zhavoronkov, Alex   +20 more
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Metabolite Profiling of Allium hookeri Leaves Using UHPLC-qTOF-MS/MS and the Senomorphic Activity of Phenolamides

Nutrients, 2023
Thi-Phuong Doan, Mi Zhang, Jorge-Eduardo Ponce-Zea   +2 more
exaly  

Targeting Senescence-Inducing Vesicles: The Endomembrane System as a Senomorphic Avenue

Secreted molecules as cytokines, chemokines, grow factors and the release of small extracellular vesicles (sEV) modulate the cellular microenvironment. Senescent cells main characteristics are the inhibition of the cell cycle, an increased β-galactosidase activity and a specific secretome of the previous compounds known as Senescence Associated ...
Lucio-Gallego, Sergio, Mato-Basalo, Rocío, Carrera, Mónica, Gutiérrez, Lola, Gil, Concha, Mateos, Jesús, Arufe, María C., Fafián-Labora, Juan   +7 more
openaire   +1 more source

Metabolite Profiling of Rambutan (Nephelium lappaceum L.) Seeds Using UPLC-qTOF-MS/MS and Senomorphic Effects in Aged Human Dermal Fibroblasts

Nutrients, 2020
Hyo Moon Cho, Eun-Jin Park, Mi Zhang
exaly  

Identification of a novel senomorphic agent, avenanthramide C, via the suppression of the senescence-associated secretory phenotype

Mechanisms of Ageing and Development, 2020
Da Young Lee, Hyung–Seok Kim, Joon Tae Park   +2 more
exaly  

Shotgun Study Reveals Senomorphic Targets Based on SASP Mediated by SEV

Cells have the capacity to modulate the microenvironment through the secretion of molecules (cytokines, chemokines, matrix proteins…) and vesicles, which vary according to the pathology involved, such as cancer or the natural process such as senescence.
Lucio-Gallego, Sergio, Mato-Basalo, Rocío, Alarcón-Veleiro, Carmen, Berjawi, Lama, López-Calvo, Ismael, Carrera, Mónica, Gutiérrez, Lola, Gil, Concha, Mateos, Jesús, Arufe, María C., Fafián-Labora, Juan   +10 more
openaire   +1 more source

Zingiber officinale Roscoe Rhizome Extract Exerts Senomorphic and Anti-Inflammatory Activities on Human Endothelial Cells

Biology, 2023
Giulia Matacchione, Vittoria Borgonetti, Deborah Ramini   +2 more
exaly  

National Institute on Aging Workshop: Repurposing Drugs or Dietary Supplements for Their Senolytic or Senomorphic Effects: Considerations for Clinical Trials

Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2021
Evan C Hadley
exaly  

Maternal diabetes induces senescence and neural tube defects sensitive to the senomorphic rapamycin

Science Advances, 2021
Cheng Xu, Wei-Bin Shen, Sunjay Kaushal   +2 more
exaly  

Senolytics and senomorphics: new treatments on the door?

Endocrine Abstracts
openaire   +1 more source