Results 111 to 120 of about 508 (143)

Senomorphic combination therapy

open access: yes
양은제   +4 more
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Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies

open access: yesInternational Journal of Molecular Sciences
Senolytic and senomorphic therapies have gained more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the “normal” cells. Aging is not a disease.
Harald Kühnel, Michael Maurer
exaly   +4 more sources

Effective and Stable Senomorphic Apigenin Delivery System Obtained by Supercritical Carbon Dioxide Processing

open access: yesInternational Journal of Molecular Sciences
Apigenin (AP) is a natural flavonoid with senomorphic potential and neuroprotective action; however, poor aqueous solubility (<1 μg/mL) limits its bioavailability and therapeutic use.
Anna Stasiłowicz-Krzemień   +2 more
exaly   +5 more sources

A Senomorphic‐Conjugated Scaffold for Application of Senescent Cells in Regenerative Medicine

open access: yesAdvanced Therapeutics, 2023
AbstractProcuring a sufficient amount of cells is essential for cell‐based regenerative therapy. However, the application of senescent cells replicated using cell culture is limited because the cells have lost their regenerative ability or produce deleterious senescence‐associated secretory phenotypes (SASPs).
Yoshitomo Honda
exaly   +2 more sources

Metabolite Profiling of Allium hookeri Leaves Using UHPLC-qTOF-MS/MS and the Senomorphic Activity of Phenolamides

open access: yesNutrients, 2023
The plant Allium hookeri, a member of the Allium genus, has a rich history of culinary and medicinal use. Recent studies have unveiled its potent antioxidant and anti-inflammatory properties. While research on A.
Phuong Doan, Byeol Ryu, Mai V H
exaly   +2 more sources
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Metabolite Profiling of Rambutan (Nephelium lappaceum L.) Seeds Using UPLC-qTOF-MS/MS and Senomorphic Effects in Aged Human Dermal Fibroblasts

open access: yesNutrients, 2020
Nephelium lappaceum (rambutan) is an edible tropical fruit that is widely grown in Southeast Asia. In general, the seeds contain high nutrients, but rambutan seeds are thrown out during processing. In this study, the anti-aging activity of rambutan seeds
Phuong Doan, Bawool Lee, Eun Jin Park
exaly   +2 more sources

Emerging use of senolytics and senomorphics against aging and chronic diseases

Medicinal Research Reviews, 2020
AbstractSenescence is a state of cell cycle arrest that plays an important role in embryogenesis, wound healing and protection against cancer. Senescent cells also accumulate during aging and contribute to the development of age‐related disorders and chronic diseases, such as atherosclerosis, type 2 diabetes, osteoarthritis, idiopathic pulmonary ...
Jan Martel   +7 more
openaire   +4 more sources

Exploring the fuzzy border between senolytics and senomorphics with chemoinformatics and systems pharmacology

Biogerontology, 2022
Senescent cells accumulate within tissues during aging and secrete an array of pro-inflammatory molecules known as senescent-associated secretory phenotype (SASP), which contribute to the appearance and progression of various chronic degenerative diseases.
Kevin Samael Olascoaga-Del Angel   +4 more
openaire   +2 more sources

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