Insights from Preclinical Data [PDF]
Funding Information: National Funds via FCT (Foundation for Science and Technology) through the Strategic Projects UIDB/04539/2020 and UIDP/04539/2020 (CIBB) and the Exploratory Project PATCH (022.05810.PTDC) and BPI/La Caixa Foundation and FCT under the
Alves-Silva, Jorge +3 more
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Cell RegenerationThe COVID-19 pandemic has caused a global health crisis and significant social economic burden. While most individuals experience mild or non-specific symptoms, elderly individuals are at a higher risk of developing severe symptoms and life-threatening ...
Yuan Yu +7 more
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Diagnostic and Therapeutic Approaches for Heart Failure in Long-Term Survivors of Childhood Cancer [PDF]
The improvement in survival rates in pediatric malignancies has led to an increase in the number of cancer survivors who are at risk of developing cardiotoxicity and heart failure. Cardiac dysfunction in these patients can occur asymptomatically, and the
Anguita Sánchez, Manuel +7 more
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Cellular senescence and wound healing in aged and diabetic skin [PDF]
Cellular senescence is a biological mechanism that prevents abnormal cell proliferation during tissue repair, and it is often accompanied by the secretion of various factors, such as cytokines and chemokines, known as the senescence-associated secretory ...
Arisa Kita +4 more
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Immunosenescence and Ageing: An Entangled Web of Senescence and Declining Immunity
Frontiers in Bioscience-LandmarkAgeing is a progressive functional decline in health conditions and a risk factor for many chronic diseases. To address the elevated burden of age-related pathologies, the ageing process has been extensively studied over the past decades, and yet the ...
Afsar U. Ahmed
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Lens epithelial cells senescence in cataract pathogenesis and emerging therapeutic opportunities
Frontiers in Cell and Developmental BiologyLens epithelial cells (LECs) senescence is a central pathogenic mechanism in cataract formation, driven by a variety of chronic stressors such as oxidative damage, UV radiation, metabolic disturbances, and mechanical strain.
Liangning Cui +7 more
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Repurposing the plant-derived compound apigenin for senomorphic effect in antiaging pipelines
AbstractCellular senescence is a cell fate triggered by inherent or environmental stress and characterized by stable cell cycle arrest accompanied by a hypersecretory feature, termed as the senescence-associated secretory phenotype (SASP). Senescent cell burden increases with natural aging, functionally contributing to age-related organ dysfunction and
Hongwei Zhang +7 more
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Advanced ScienceThe pursuit of pharmacological interventions in aging aims focuses on maximizing safety and efficacy, prompting an exploration of natural products endowed with inherent medicinal properties.
Jiqun Wang +11 more
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Cellular Senescence in Keloid Pathology: Mechanisms, Biomarkers, and Potential Therapeutic Targets
BiomedicinesA keloid is a benign fibroproliferative cutaneous disorder characterized by excessive extracellular matrix deposition, which is driven by persistent fibroblast proliferation and aberrant wound healing.
Yujiang Luo +3 more
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Therapy-induced senescence in normal fibroblasts promotes in vitro tumour cell growth and invasiveness: study of the role of Quercetin in modulating these processes. [PDF]
, 2022 Bientinesi, Elisa, Monti, Daniela
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