Results 91 to 100 of about 2,081 (185)

Unleashing endogenous regeneration by senolytics

Journal of Translational Medicine
Abstract Regenerative medicine holds significant promise for the treatment of chronic diseases by harnessing the body’s innate capacity to repair and restore physiological function. However, regenerative activity declines markedly with age, a phenomenon traditionally attributed to depletion/exhaustion of progenitor cell pools.
Boddu, Navneet K., Kesari, Santosh, Chavez, Brandy A., Bajnath, Anil, Wheatley, Maxim D., Zhang, Qianyi, Wang, Yiqiao, Ellis, Joseph, Lin, Emma, Genovese, Jorge, Robles, Maria Fatima N.   +10 more
openaire   +2 more sources

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Understanding extracellular vesicles in antiaging

Periodontology 2000, EarlyView.
Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad, Nathan E. Estrin, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Identification and characterization of Cardiac Glycosides as senolytic compounds [PDF]

, 2019
Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the causal involvement of senescence in aging and offer therapeutic interventions.
Pietrocola, F., COLLADO RODRIGUEZ, MANUEL, Rodilla, V., González, P., Prats, N., Del Pino, Pablo, Gonzalez, Patricia, Da Silva-Álvarez, Sabela, Llanos, S., Pedrosa, Pablo, Loza, María I, Triana-Martínez, Francisco, Rodilla, Verónica, Del Pino, P., Soprano, Enrica, Gómez, M., Bernadó, C., Picallos-Rabina, Pilar, Domínguez, Eduardo, Vidal Figueroa, Anxo, Barradas, M., Serrano Marugan, Manuel, Ferreirós, Alba, Fernández-Marcos, Pablo J, Hernández-González, Fernanda, González Barcia, Miguel, Collado, Manuel, Arribas, J., Hernández-González, F., Vidal, Anxo, Lalinde, Marta, Gómez, María, Bernadó, Cristina, Barradas, Marta, Ferreirós, A., Fernández-Marcos, P. J., Pietrocola, Federico, Pedrosa, P., LLanos, Susana, González-Barcia, Miguel, Serrano, M., Ikonomopoulou, Maria P, Prats, Neus, Loza, M. I., García-Caballero, T., Domínguez, E., Arribas, Joaquín, Triana-Martínez, F., Soprano, E., Da Silva-Álvarez, S., García-Caballero, Tomás, Lalinde, M., Ikonomopoulou, M. P., Picallos-Rabina, P.   +53 more
core   +1 more source

Clearance of p16‐positive cardiac cells improves age‐related cardiac remodeling in mice

Experimental Physiology, EarlyView.
Abstract Senescent cells are characterized by expression of markers like p16 and secretion of profibrotic and proinflammatory factors. The role of cellular senescence in age‐related cardiac remodeling and dysfunction is incompletely understood. This study aimed to: (i) evaluate the effect of p16‐ positive cell clearance on cardiac function and ...
Mozhdeh Mehdizadeh, Martin Mackasey, Kimia Gharagozloo, Martin Aguilar, Patrice Naud, Allan Ochs, Nhung Vuong‐Robillard, Eric Thorin, Gerardo Ferbeyre, Jean‐Claude Tardif, Martin G. Sirois, Jean Francois Tanguay, Stanley Nattel   +12 more
wiley   +1 more source

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

A Senolytic-Eluting Coronary Stent for the Prevention of In-Stent Restenosis

, 2022
The vast majority of drug-eluting stents (DES) elute either sirolimus or one of its analogues. While limus drugs stymie vascular smooth muscle cell (VSMC) proliferation to prevent instent restenosis, their antiproliferative nature is indiscriminate and ...
Seokhyeong Go, Kim, Cheesue, Seul-Gee Lee, Songhyun Lim, Seung-Jun Lee, Mikyung Kang, Hee Su Sohn, Go, Seokhyeong, Jung, Mungyo, Lee, Seung-Jun, Kim, Byung-Soo, Sohn, Hee Su, Jung-Sun Kim, Byung-Soo Kim, Kwon, Sung Pil, Lee, Seul-Gee, Sangjun Moon, Mungyo Jung, Lim, Songhyun, Kang, Mikyung, Cheesue Kim, Sung Pil Kwon, Kim, Jung-Sun, Jihye Hong, Hong, Jihye, Moon, Sangjun   +25 more
core   +1 more source

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Junctional Adhesion Molecule‐A (JAM‐A) Associates With High‐Risk Disease in Multiple Myeloma Patients and a Structure‐Based Rationally‐Designed Peptide Inhibitor Attenuates Tumorigenic Features In Vitro and In Vivo

European Journal of Haematology, Volume 117, Issue 4, Page 995-1006, October 2026.
ABSTRACT Multiple myeloma (MM) is an incurable malignancy of terminally‐differentiated plasma cells that represents a major clinical challenge despite unprecedented therapeutic advances, particularly for patients with cytogenetically‐defined high‐risk MM (HR‐MM).
Niamh McAuley, Roisin McAvera, Dimitri Bong, Lara Donnelly, Izabela Cymer, Marian Brennan, Joanna Fay, Lance Hudson, John Quinn, Siobhan V. Glavey, Ann M. Hopkins   +10 more
wiley   +1 more source

ε-Viniferin Rejuvenates Senescence via RGS16 Regulation: In Vitro Evidence

Pharmaceuticals
Background: Reactive oxygen species (ROS) generated due to mitochondrial dysfunction are one of the primary causes of the initiation and progression of senescence.
Ji Ho Park, Yun Haeng Lee, Kyeong Seon Lee, Yoo Jin Lee, Jee Hee Yoon, Byeonghyeon So, Duyeol Kim, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Ki Yong Lee, Joon Tae Park   +11 more
doaj   +1 more source