Results 21 to 30 of about 2,081 (185)
Generation of a selective senolytic platform using a micelle-encapsulated Sudan Black B conjugated analog [PDF]
The emerging field of senolytics is centered on eliminating senescent cells to block their contribution to the progression of age-related diseases, including cancer, and to facilitate healthy aging.
Lagopati, Nefeli +22 more
core +14 more sources
Senolytics in the treatment of diabetic retinopathy
Frontiers in Pharmacology, 2022 Diabetic retinopathy (DR) is the most common complication of diabetes. DR is characterized by damage to retinal vasculature resulting in vision impairment and, if untreated, could eventually lead to blindness. The pathogenic mechanism of DR is complex; emerging studies suggest that premature senescence of retinal cells and subsequent secretion of ...
Hassan, Jannah Waled +1 more
openaire +4 more sources
Identification of SYK inhibitor, R406 as a novel senolytic agent [PDF]
, 2020 The selective removal of senescent cells by senolytics is suggested as a potential approach to reverse aging and extend lifespan. Using high-throughput screening with replicative senescence of human diploid fibroblasts (HDFs), we identified a novel ...
Park, Sang Chul +7 more
core +1 more source
Senescence explains age- and obesity-related liver steatosis
Cell Stress, 2017 Cellular senescence, the irreversible loss of replicative potential of somatic cells, was first described in fibroblasts cultured in vitro by Leonard Hayflick more than 50 years ago.
Mikolaj Ogrodnik, Diana Jurk
doaj +1 more source
Redox Biology, 2020 Cellular senescence may contribute to aging and age-related diseases and senolytic drugs that selectively kill senescent cells may delay aging and promote healthspan.
Anna Lewinska +8 more
doaj +1 more source
Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
openaire +1 more source
The Clinical Potential of Senolytic Drugs [PDF]
Journal of the American Geriatrics Society, 2017 Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic ...
James L, Kirkland +4 more
openaire +2 more sources
Improvement of the ability of bone repair by reducing the aging degree of mesenchymal stem cell population by Senolytic drugs [PDF]
E3S Web of Conferences, 2021 In order to study the effects of Senolytic drugs dasatinib and quercetin on the aging of mesenchymal stem cells (MSCs) and explore the application of young MSCs in repairing bone defects, the cultured and identified MSCs were treated with dasatinib and ...
Liu Jia, He Lian, Zhou Peng, Chen Danna
doaj +1 more source
Strategies for senolytic drug discovery
Aging Cell, 2023 AbstractSenolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. Since the discovery of the first senolytics in 2015, the number of known senolytic agents has grown dramatically.
Helen Power +3 more
openaire +2 more sources
Frontiers in Pharmacology, 2018 Cellular senescence is identified by a living cell in irreversible and persistent cell cycle arrest in response to various cellular stresses. Senescent cells secrete senescence-associated secretory phenotype factors that can amplify cellular senescence ...
Mengqian Li +3 more
doaj +1 more source