Results 21 to 30 of about 9,248 (241)
Molecular Oncology, 2020 Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can contribute to unfavorable patient outcomes, potentially including disease relapse.
Tareq Saleh +10 more
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Why Senescent Cells Are Resistant to Apoptosis: An Insight for Senolytic Development
Frontiers in Cell and Developmental Biology, 2022 Cellular senescence is a process that leads to a state of irreversible cell growth arrest induced by a variety of intrinsic and extrinsic stresses. Senescent cells (SnCs) accumulate with age and have been implicated in various age-related diseases in ...
Li Hu +12 more
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Redox Biology, 2020 Cellular senescence may contribute to aging and age-related diseases and senolytic drugs that selectively kill senescent cells may delay aging and promote healthspan.
Anna Lewinska +8 more
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Strategies for senolytic drug discovery
Aging Cell, 2023 AbstractSenolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. Since the discovery of the first senolytics in 2015, the number of known senolytic agents has grown dramatically.
Helen Power +3 more
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Nature Biotechnology, 2020 Despite early failures in the clinic, the idea of anti-aging therapies that purge the body of dying cells is gaining traction with a raft of startups now focused on senescence.
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Senolytics in the treatment of diabetic retinopathy
Frontiers in Pharmacology, 2022 Diabetic retinopathy (DR) is the most common complication of diabetes. DR is characterized by damage to retinal vasculature resulting in vision impairment and, if untreated, could eventually lead to blindness. The pathogenic mechanism of DR is complex; emerging studies suggest that premature senescence of retinal cells and subsequent secretion of ...
Hassan, Jannah Waled +1 more
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The Clinical Potential of Senolytic Drugs [PDF]
Journal of the American Geriatrics Society, 2017 Senolytic drugs are agents that selectively induce apoptosis of senescent cells. These cells accumulate in many tissues with aging and at sites of pathology in multiple chronic diseases. In studies in animals, targeting senescent cells using genetic or pharmacological approaches delays, prevents, or alleviates multiple age‐related phenotypes, chronic ...
James L, Kirkland +4 more
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Nintedanib induces senolytic effect via STAT3 inhibition
Cell Death and Disease, 2022 Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even for reversing aging.
Hyun-Ji Cho +8 more
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Recent advances in the discovery of senolytics
Mechanisms of Ageing and Development, 2021 The demonstration in model organisms that cellular senescence drives aging and age-related diseases has led to widespread efforts to identify compounds able to selectively kill senescent cells, termed senolytics. Approaches used to identify senolytics include bioinformatic analysis of senescent cell anti-apoptotic pathways (SCAPs) for drug development ...
Lei Zhang +4 more
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Senescence and Senolytics: State of the Art on Cellular Senescence, Senolytics, and Healthspan [PDF]
Innovation in Aging, 2020 Abstract Cellular senescence is a cell fate decision that is made by many mammalian cell types in response to damage, stress or certain physiological signals. Senescent cells arrest proliferation, essentially permanently, and develop a complex multi-component senescence-associated secretory phenotype (SASP).
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