Results 81 to 90 of about 416 (129)

Plant-Derived Senotherapeutics for the Prevention and Treatment of Intervertebral Disc Degeneration and Aging

Chronic low back pain, a major cause of disability with a great global socioeconomic impact, has been inextricably associated with intervertebral disc degeneration.
Dimitris Kletsas, Eleni Mavrogonatou
core   +1 more source

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes

Clinical and Translational Medicine
Tumour cell senescence can be induced by various factors, including DNA damage, inflammatory signals, genetic toxins, ionising radiation and nutrient metabolism.
Jiaqiang Xiong, Lu Dong, Qiongying Lv, Yutong Yin, Jiahui Zhao, Youning Ke, Shixuan Wang, Wei Zhang, Meng Wu   +8 more
doaj   +1 more source

Therapy-induced senescence through the redox lens

Redox Biology
Therapy-induced senescent tumor cells have emerged as significant drivers of tumor recurrence and disease relapse. Interestingly, reactive oxygen species (ROS) production and its associated redox signaling networks are intertwined with initiation and ...
Matius Robert, Brian K. Kennedy, Karen C. Crasta   +2 more
doaj   +1 more source

Editorial: Cellular Senescence: Causes, Consequences and Therapeutic Opportunities

Frontiers in Cell and Developmental Biology, 2022
Pooi-Fong Wong
doaj   +1 more source

Senescence intensifies bleomycin-induced injury in idiopathic pulmonary fibrosis lung epithelial cells

ERJ Open Research
Introduction Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease involving injury and a dysregulated repair response of an ageing epithelium. Here we investigate the contribution of senescence and telomere shortening to bleomycin-induced injury ...
Jane Read, Andrew T. Reid, Claire Thomson, Marshall Plit, Que Tran La, Ross Mejia, Pankaj Saxena, Darryl A. Knight, Muriel Lizé, Cecilia M. Prêle, Christopher L. Grainge, Heiko Stahl, Michael Schuliga   +12 more
doaj   +1 more source

Simultaneous induction of differentiation and senescence in cardiac fibroblasts by TGF-β1: effects of senotherapeutics drugs

Frontiers in Pharmacology
IntroductionAging is a major risk factor for cardiovascular diseases (CVD), partly due to the accumulation of senescent cells. Senescence is characterized by irreversible cell cycle arrest and the acquisition of a senescence associated secretory ...
Claudio Espinoza-Perez, José Miguel Osorio, Rubén Vélez, Juan Ortega Bustos, Víctor Machuca, Sebastián Rivas, Carlos F. Sánchez-Ferrer, Carlos F. Sánchez-Ferrer, Concepción Peiró, Concepción Peiró, Raúl Vivar, Guillermo Díaz-Araya, Guillermo Díaz-Araya   +12 more
doaj   +1 more source

Integrating senotherapeutics into transplantation: liver reconditioning in an aging donor pool

Transplant International
Our aging population is reshaping transplantation medicine. As demand for liver transplantation continues to rise, an aging donor pool presents unique challenges, with marginal organs becoming increasingly prevalent and representing a critical yet ...
Madita L. Buch, Hannah Esser, Himath Perera, Runshi Zheng, Sofia Ferreira-Gonzalez, Stuart J. Forbes   +5 more
doaj   +1 more source

The promise of organ rejuvenation to overcome the shortage in organ transplantation

Nature Communications
Organ shortage remains a major barrier in treating end-stage organ failure, with many patients dying while waiting or becoming medically unfit by the time an organ is offered.
Mukhammad Kayumov, Zhuolun Song, Friederike Martin, Sarah Tsou, Yao Xiao, Hao Zhou, Stefan G. Tullius   +6 more
doaj   +1 more source

The Emerging Field of Senotherapeutic Drugs [PDF]

Future Medicinal Chemistry, 2018
openaire   +3 more sources

Plant-Derived Senotherapeutics in Cellular Senescence: A Scoping Review of Preclinical Evidence, Mechanistic Pathways, and Metabolomic-Guided Discovery

Senotherapeutic agents targeting senescent cell (SnC) accumulation represent a promising frontier in aging research. These agents encompass senolytics that selectively eliminate accumulated SnCs and senomorphics that suppress the pathological persistence
Nor Muhammad Hilmi Hussin, Rahma Micho Widyanto, Ahmed Mediani, Razinah Sharif, Michael Fenech, Normala Abd Latip   +5 more
core   +1 more source