Results 81 to 90 of about 1,366 (168)

Senotherapeutics: Targeting senescence in idiopathic pulmonary fibrosis

Seminars in Cell & Developmental Biology, 2020
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic lung disease characterized by progressive scarring of the lung tissue, leading to respiratory failure. There is no cure for IPF, and current anti-fibrotic treatments modestly arrest its further progression. IPF prevalence and incidence increase with age, which is a recognized risk factor.
Wolfgang, Merkt, Marta, Bueno, Ana L, Mora, David, Lagares   +3 more
openaire   +3 more sources

Table4_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.XLS

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

Systematic Druggable Genome‐Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Currently, there are no effective drug treatments for aging. Mendelian randomization (MR) has been widely applied to repurpose existing drugs and identify new therapeutic targets. Our aim is to identify aging‐related therapeutic targets and evaluate their potential adverse effects, underlying mechanisms, and actionable ...
Yanfang Zhang, Menglong Wang, Hang Li, Ting Jin, Shanshan Peng, Yi Dong, Chaowei Deng, Hang Li, Xinyi Li, Juanjuan Qin, Xujun Ye   +10 more
wiley   +1 more source

Table5_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.XLSX

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

Cells in Atherosclerosis: Focus on Cellular Senescence from Basic Science to Clinical Practice

, 2023
Aging is a major risk factor of atherosclerosis through different complex pathways including replicative cellular senescence and age-related clonal hematopoiesis. In addition to aging, extracellular stress factors, such as mechanical and oxidative stress,
Dorottya Tímea Pásztor, Zsófia Tarcza, Andrea Ágnes Molnár, Béla Merkely   +3 more
core   +1 more source

Enhancing adipose tissue functionality in obesity: senotherapeutics, autophagy and cellular senescence as a target

Obesity, a global health crisis, disrupts multiple systemic processes, contributing to a cascade of metabolic dysfunctions by promoting the pathological expansion of visceral adipose tissue (VAT).
Arias, Consuelo, Kerr, Bredford, Javiera Álvarez-Indo, Burgos, Patricia V., Bredford Kerr, Mariana Cifuentes, Morselli, Eugenia, Consuelo Arias, Cifuentes, Mariana, Eugenia Morselli, Álvarez-Indo, Javiera, Patricia V. Burgos   +11 more
core   +1 more source

Effects of LDD-2269 on the Senescence of Glioblastoma Cells

, 2020
Background and Objective: Cellular senescence manifests as cell cycle arrest accompanied by phenotypic changes such as deregulated metabolism and specialized secretory activity.
Lee, Hyo Jeong, Bang, Minji, Shin, Chan Young, Kim, Yong-Chul, Han, Sun-Young   +4 more
core   +1 more source

Cellular senescence in cancer: molecular mechanisms and therapeutic targets

MedComm
Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes.
Ping Jin, Xirui Duan, Lei Li, Ping Zhou, Cheng‐Gang Zou, Ke Xie   +5 more
doaj   +1 more source

SGLT2 inhibitors as a novel senotherapeutic approach

npj Aging
Abstract Cellular senescence is the permanent cessation of cell proliferation and growth. Senescent cells accumulating in tissues and organs with aging contribute to many chronic diseases, mainly through the secretion of a pro-inflammatory senescence-associated secretory phenotype (SASP).
Zeynep Elif Yesilyurt-Dirican, Ce Qi, Yi-Chian Wang, Annika Simm, Laura Deelen, Alia Hafiz Abbas Gasim, Fiona Lewis-McDougall, Georgina M. Ellison-Hughes   +7 more
openaire   +2 more sources

Cellular senescence: defining a path forward [PDF]

, 2019
Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Thus, accurate detection of senescent cells, especially in vivo, is essential especially since the field of senotherapeutics is
Niedernhofer, L., Bennett, DC, Bischof O., Collado, M, Vougas, K., Maier, Andrea B., von Zglinicki, Thomas, Robbins, P.D., Adams, Peter D, Campisi, J., Alimonti, Andrea, Maier, Andrea, Jurk, D., Passos, João F., Hara E., Adams, P.D., Passos, João F, Bennett, Dorothy C., Collado Rodríguez, Manuel, Maier, A. B., Niedernhofer, Laura J., Serrano, Manuel, Adams PD, Demaria, M., Campisi, J, Ferbeyre, G, Evangelou K, von Zglinicki, T., Collado M, Niedernhofer, Laura, Robbins, Paul D, Zhou, D., Campisi J., Demaria, Marco, von Zglinicki T, Zglinicki, Thomas von, Krizhanovsky V, Bishop, Cleo, Maier, AB, Serrano M, Adams, Peter D., Bishop, C., Hara E, Sedivy, J, Schmitt, C. A., Jurk, D, Gil, J, Niedernhofer, L, Passos, JF, Gil J, Gil, J., Gorgoulis, V., Robbins, PD, Sedivy J., Serrano M., Krizhanovsky, V, Bennett, D. C., Zhou D, Bishop C., Sedivy, J., Bischof O, Sedivy J, Demaria, M, Campisi, Judith, Ferbeyre, Gerardo, Gorgoulis, V, Niedernhofer L., Adams P. D., Narita M., Serrano, M., Bishop, C, Bishop C, Schmitt CA, Robbins, Paul, Passos, João, Hara, Eiji, Bennett, Dorothy C, Vougas, Konstantinos, Maier A. B., Vougas K, Evangelou, K, Bennett DC, Evangelou, Konstantinos, Ferbeyre, G., Maier, Andrea B, Gil J., Evangelou K., Bischof, O, Vougas K., Hara, E., Ferbeyre G., Robbins P. D., Adams, Peter, Demaria, Marco; id_orcid, Serrano, M, Krizhanovsky V., von Zglinicki T., Gil, Jesús, Jurk D., Maier, A.B., Bennett, D.C., Alimonti A., Bischof, O., Zhou, Daohong, Demaria M., Narita, Masashi, Krizhanovsky, V., Krizhanovsky, Valery, Schmitt, C.A., Passos, J. F., Passos J. F., Niedernhofer L, Ferberyre, G, Passos, J.F., Zhou, D, Robbins, P. D., Narita, M, Alimonti, A, Alimonti A, Sedivy, John, Evangelou, K., Campisi J, Collado, M., Maier AB, Maier, Andrea B.; id_orcid, Vougas, K, Collado M., Gorgoulis V, Collado, Manuel, Passos JF, Gorgoulis V., Schmitt, Clemens A, Narita, M., Robbins, Paul D., Schmitt, Clemens, Jurk, Diana, Schmitt C. A., Jurk D, Zhou, D. H., Ferbeyre G, von Zglinicki, T, Demaria M, Zhou D., Adams, P. D., Schmitt, Clemens A., Hara, E, Alimonti, A., Robbins PD, Gorgoulis, Vassilis, Adams, PD, Schmitt, CA, Bennett D. C., Bischof, Oliver, Narita M, Bennett, Dorothy   +154 more
core   +1 more source