Results 61 to 70 of about 1,366 (168)

Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications

Frontiers in Cell and Developmental Biology, 2021
Mesenchymal stem cells (MSC) isolated from different tissue sources exhibit multiple biological effects and have shown promising therapeutic effects in a broad range of diseases.
Juan Zhang, Juan Zhang, Mingzhuang Chen, Mingzhuang Chen, Mingzhuang Chen, Jinqi Liao, Chongfei Chang, Yuqing Liu, Arshad Ahmed Padhiar, Arshad Ahmed Padhiar, Yan Zhou, Guangqian Zhou, Guangqian Zhou, Guangqian Zhou   +13 more
doaj   +1 more source

The Aging Microenvironment Shapes Angiogenic Remodeling in IBD‐Associated Colorectal Carcinogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
In IBD, chronic inflammation promotes cellular senescence across epithelial, stromal, endothelial, and immune compartments. The resulting SASP drives pathological angiogenesis, vascular dysfunction, hypoxia, and immune suppression, thereby facilitating progression from inflammation to dysplasia and colitis‐associated colorectal cancer.
Ruoshu Duan, Qingyu Chen, Yuan Xu, Ye Yan, Sujing Jiang   +4 more
wiley   +1 more source

Table3_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.XLS

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

Therapy-induced senescence in breast cancer: an overview

Exploration of Targeted Anti-tumor Therapy
Outcomes for women with breast cancer have improved dramatically in recent decades. However, many patients present with intrinsic drug resistance and others are initially sensitive to anti-cancer drugs but acquire resistance during the course of their ...
Suraj Narayanan Chembukavu, Andrew J Lindsay   +1 more
doaj   +1 more source

Nanocarriers for natural polyphenol senotherapeutics

Aging Cell
AbstractSenescence is a heterogenous and dynamic process in which various cell types undergo cell‐cycle arrest due to cellular stressors. While senescence has been implicated in aging and many human pathologies, therapeutic interventions remain inadequate due to the absence of a comprehensive set of biomarkers in a context‐dependent manner. Polyphenols
Natali Joma, Patrick‐Brian Bielawski, Anjali Saini, Ashok Kakkar, Dusica Maysinger   +4 more
openaire   +2 more sources

Senescent Myoblasts Exhibit ROS‐Dependent Akt‐mTORC1 Dysregulation and Are Susceptible to Reductive Stress‐Induced Cell Death

Aging Cell, Volume 25, Issue 6, June 2026.
Senescent myoblasts exhibit dysregulated Akt/mTORC1 signalling. Antioxidants can alleviate this dysregulation, as well as other downstream senescent phenotypes. Moreover, prolonged antioxidant treatment can selectively induce cell death in senescent myoblasts, suggesting that these cells are more susceptible to reductive stress.
Vladimir Belhac, Alex Dillingham, Emilia Coward, Bradley Teal, Mark C. Turner, Stephanie D. Gagnon, Jiani Qian, Harry Wilford, Ella Warren, Natalie Moger, Bernadette Carroll, Owen G. Davies, Hannah F. Dugdale, Neil R. W. Martin   +13 more
wiley   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Engineering nanoformulations for senotherapeutics delivery

Mauro Rodrigo Dias Henriques
openaire   +3 more sources

Table2_Proteomic and Biological Analysis of the Effects of Metformin Senomorphics on the Mesenchymal Stromal Cells.XLSX

, 2021
Senotherapeutics are new drugs that can modulate senescence phenomena within tissues and reduce the onset of age-related pathologies. Senotherapeutics are divided into senolytics and senomorphics.
Mustafa Burak Acar (11523127), Gianfranco Peluso (284822), Giovanni Di Bernardo (696468), Zeynep Gunaydin (11523133), Umberto Galderisi (376215), Şerife Ayaz-Güner (11523130), Servet Özcan (2891885), Musa Karakukcu (11523136)   +7 more
core   +1 more source

From Mesenchymal Stromal Cells to Extracellular Vesicles: Scalable Strategies for Ovarian Stroma Regeneration

Molecular Reproduction and Development, Volume 93, Issue 5, May 2026.
ABSTRACT Ovarian aging is characterized by the reduction of the follicular pool and a progressive loss in oocyte quality. Although these changes have initially been attributed to oocyte alterations, increasing evidence indicates that stromal deterioration plays a central role in this process.
Stefhani Martins Barcelos, Amandda Évelin Silva‐Carvalho, Felipe Perecin, Juliana Lott Carvalho   +3 more
wiley   +1 more source