Results 61 to 70 of about 1,649 (193)

Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics

Antioxidants, 2023
Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however,
Darya Bulbiankova, Rocío Díaz-Puertas, Francisco Javier Álvarez-Martínez, María Herranz-López, Enrique Barrajón-Catalán, Vicente Micol   +5 more
doaj   +1 more source

Exploring the Intersections of Immunosenescence and Cellular Senescence in Health and Disease [PDF]

This thesis provides a comprehensive investigation into the role of cellular senescence in immune cells, focusing on macrophages and microglia in aging, diseases, and therapeutic responses, as well as the immune landscape during COVID-19.
Melo, Letícya
core   +1 more source

Co‐pathologies and biological processes beyond amyloid‐beta and tau in people with Alzheimer's disease: Evidence from clinical cohort studies

Journal of Internal Medicine, Volume 299, Issue 6, Page 694-710, June 2026.
Abstract Alzheimer's disease (AD) is neuropathologically defined by amyloid‐beta (Aβ) plaques and tau neurofibrillary tangles. However, co‐pathologies and other pathobiological processes are involved in the pathogenesis of AD, contributing to neurodegeneration and clinical symptoms.
Daniel Ferreira, Tomasz Chmiela, Maria Eriksdotter, Clifford R. Jack Jr., Grégoria Kalpouzos, Anna Marseglia, Patrizia Mecocci, Agneta Nordberg, Dorota Religa, Eric Westman   +9 more
wiley   +1 more source

Cellular senescence: Molecular signatures and cellular remodeling

FEBS Open Bio, Volume 16, Issue 5, Page 818-820, May 2026.
Cellular senescence, a state of stable cell‐cycle arrest accompanied by profound metabolic and secretory changes, has emerged as a central hallmark of aging and a key contributor to age‐associated diseases. Despite the great progress in understanding the characteristics, the underlying molecular mechanisms, and the role of senescent cells in several ...
Dimitris Kletsas
wiley   +1 more source

Mitochondrial dysfunction and alveolar type II epithelial cell senescence: The destroyer and rescuer of idiopathic pulmonary fibrosis

Frontiers in Cell and Developmental Biology
Idiopathic pulmonary fibrosis (IPF) is a chronic respiratory disease with an unknown origin and complex pathogenic mechanisms. A deeper understanding of these mechanisms is essential for effective treatment.
Suqi Liu, Qian Xi, Xuannian Li, Huaman Liu   +3 more
doaj   +1 more source

Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Hold Lower Heterogeneity and Great Promise in Biological Research and Clinical Applications

Frontiers in Cell and Developmental Biology, 2021
Mesenchymal stem cells (MSC) isolated from different tissue sources exhibit multiple biological effects and have shown promising therapeutic effects in a broad range of diseases.
Juan Zhang, Juan Zhang, Mingzhuang Chen, Mingzhuang Chen, Mingzhuang Chen, Jinqi Liao, Chongfei Chang, Yuqing Liu, Arshad Ahmed Padhiar, Arshad Ahmed Padhiar, Yan Zhou, Guangqian Zhou, Guangqian Zhou, Guangqian Zhou   +13 more
doaj   +1 more source

Targeting Hyperoxia‐Induced Cellular Senescence in Developing Human Airway Cells: Senomorphics Versus Senolytics Versus Antioxidants

Aging Cell, Volume 25, Issue 5, May 2026.
Supplemental oxygen is critical for premature infants. While initially beneficial, even moderate hyperoxia (< 60% O2) induces detrimental cellular senescence in developing airways with long‐lasting consequences. Senotherapeutics such as Fucoidan, Dasatinib (D) + Quercetin (D + Q), and mitochondrial‐targeted antioxidant MitoQ may be beneficial in ...
Maunick Lefin Koloko Ngassie, Li Y. Drake, Yi Zhu, Yamillie Ortiz, Daniel A. Pfeffer‐Kleemann, Michael A. Thompson, Samantha K. Hamrick, Christina M. Pabelick, Y. S. Prakash   +8 more
wiley   +1 more source

Senotherapeutics to Counteract Senescent Cells Are Prominent Topics in the Context of Anti-Ageing Strategies [PDF]

Cellular senescence is implicated in ageing and associated with a broad spectrum of agerelated diseases. Importantly, a cell can initiate the senescence program irrespective of the organism’s age.
Accardi, Giulia, Aiello, Anna, Calabrò, Anna, Candore, Giuseppina, Caruso, Calogero, Galimberti, Damiano   +5 more
core   +1 more source

Fisetin is a senotherapeutic that extends health and lifespan [PDF]

EBioMedicine, 2018
Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches.
Yousefzadeh, Matthew J., Zhu, Yi, McGowan, Sara J., Angelini, Luise, Fuhrmann-Stroissnigg, Heike, Xu, Ming, Ling, Yuan Yuan, Melos, Kendra I., Pirtskhalava, Tamar, Inman, Christina L., McGuckian, Collin, Wade, Erin A., Kato, Jonathon I., Grassi, Diego, Wentworth, Mark, Burd, Christin E., Arriaga, Edgar A., Ladiges, Warren L., Tchkonia, Tamara, Kirkland, James L., Robbins, Paul D., Niedernhofer, Laura J.   +21 more
openaire   +2 more sources

Systematic Druggable Genome‐Wide Analysis Identifies Therapeutic Targets for Aging: A Mendelian Randomization Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims Currently, there are no effective drug treatments for aging. Mendelian randomization (MR) has been widely applied to repurpose existing drugs and identify new therapeutic targets. Our aim is to identify aging‐related therapeutic targets and evaluate their potential adverse effects, underlying mechanisms, and actionable ...
Yanfang Zhang, Menglong Wang, Hang Li, Ting Jin, Shanshan Peng, Yi Dong, Chaowei Deng, Hang Li, Xinyi Li, Juanjuan Qin, Xujun Ye   +10 more
wiley   +1 more source