Results 1 to 10 of about 276 (129)
The Emerging Role of Senotherapy in Cancer: A Comprehensive Review
Clinics and Practice, 2023 Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate the deleterious effects ...
Antonio Ayala +2 more
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Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment
AntioxidantsAging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant
Margarita Neganova, Yulia Aleksandrova
exaly +6 more sources
Recycling senescent cell lipids for targeted senotherapy
Nature CommunicationsSenescent cells (SnCs) are increasingly recognized as key contributors to osteoarthritis, with conventional strategies centered on their elimination.
Xu Kaicheng +2 more
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A stress-induced cilium-to-PML-NB route drives senescence initiation
Nature Communications, 2023 Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells.
Xiaoyu Ma +14 more
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Senotherapeutic Effect of Retinaldehyde and Hyaluronate Fragments in Dermatoporosis
Dermatopathology, 2023 Cellular senescence is one of the important mechanisms of skin aging. In a recent study, we have shown that in patients with dermatoporosis, an extreme senescence condition of the skin, cells positive for p16Ink4a, a biomarker of senescence, were ...
Aysin Kaya +2 more
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The interaction between cellular senescence and chronic kidney disease as a therapeutic opportunity
Frontiers in Pharmacology, 2022 Chronic kidney disease (CKD) is an increasingly serious public health problem in the world, but the effective therapeutic approach is quite limited at present.
Jing-Li Zhao +4 more
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Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Sachi Matsubayashi +3 more
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Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
Antioxidants, 2023 Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however,
Darya Bulbiankova +5 more
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Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells
Cells, 2020 The progressive accumulation of apoptosis-resistant and secretory active senescent cells (SCs) in animal and human aged tissues may limit lifespan and healthspan and lead to age-related diseases such as cancer, neurodegenerative disorders, and metabolic ...
Jagoda Adamczyk-Grochala, Anna Lewinska
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Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Ramona-Daniela Pavaloiu +4 more
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