The Emerging Role of Senotherapy in Cancer: A Comprehensive Review [PDF]
Clinics and Practice, 2023 Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate the deleterious effects ...
Sarubala Malayaperumal +7 more
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Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment [PDF]
AntioxidantsAging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant
Yulia Aleksandrova, Margarita E Neganova
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Senesens. Heart. Senotherapy [PDF]
Фармакокинетика и ФармакодинамикаSenescence — cellular aging — is a special form of cell death, characterized by the cell’s irreversible loss of its proliferation potential and the development of resistance to apoptosis.
S. A. Kryzhanovskii, M. B. Vititnova
doaj +4 more sources
Inhibition of miMOMP-induced SASP to combat age-related disease [PDF]
Frontiers in AgingCellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture.
Xiaoli Liao +4 more
doaj +5 more sources
Impact and potential value of immunosenescence on solid gastrointestinal tumors [PDF]
Frontiers in ImmunologySolid gastrointestinal tumors often respond poorly to immunotherapy for the complex tumor microenvironment (TME), which is exacerbated by immune system alterations. Immunosenescence is the process of increased diversification of immune genes due to aging
Tianshuai Zhang +8 more
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Natural killer cell-based senotherapy: a promising strategy for healthy aging [PDF]
Frontiers in ImmunologyOne of the most significant risk factors for diseases is aging. Interestingly, some organisms, such as naked mole-rats and most turtles, do not exhibit typical aging-like symptoms or increased mortality as they become older.
Tsutomu Nakazawa +4 more
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Frontiers in Endocrinology, 2023 Recent advances in aging research have provided novel insights for the development of senotherapy, which utilizes cellular senescence as a therapeutic target.
Kazuyoshi Kuwano
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Inducible skeletal muscle-specific p53 deletion alleviates high-fat diet-induced insulin resistance by modulating mitochondria-associated membrane in obese mice [PDF]
Redox Biologyp53 has been implicated in metabolic regulation, but its role in obesity-induced skeletal muscle insulin resistance remains incompletely understood. This study aimed to determine the functional contribution of skeletal muscle p53 to insulin resistance ...
Soyoung Park +12 more
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Cellular Senescence: Mechanisms and Therapeutic Potential
Biomedicines, 2021 Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both ...
Zehuan Liao, Yan Zhao
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Homoharringtonine exhibits senotherapeutic activity that mitigates diet- and age-associated obesity and insulin resistance and extends lifespan in mice [PDF]
Nature CommunicationsThe accumulation of senescent cells in white adipose tissue (WAT) is closely associated with the functional decline of WAT and plays a causal role in the pathogenesis of metabolic diseases.
Eok-Cheon Kim +27 more
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