Natural Killer Cell-Based Senotherapy: A Promising Strategy for Healthy Aging [PDF]
Frontiers in ImmunologyOne of the most significant risk factors for diseases is aging. Interestingly, some organisms, such as naked mole-rats and most turtles, do not exhibit typical aging-like symptoms or increased mortality as they become older.
Tsutomu Nakazawa, Takayuki Morimoto
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The Emerging Role of Senotherapy in Cancer: A Comprehensive Review
Clinics and Practice, 2023 Senotherapy, a promising therapeutic strategy, has drawn a lot attention recently due to its potential for combating cancer. Senotherapy refers to the targeting of senescent cells to restore tissue homeostasis and mitigate the deleterious effects ...
Sarubala Malayaperumal +2 more
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Pathological Mechanism‐Inspired Biomimetic Nano‐Senotherapy for Reversing Experimental Atherosclerosis in ApoE−/− Mice [PDF]
Advanced ScienceThe greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and obstructs ...
Yuhan Tian +9 more
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Cellular Senescence in Skeletal Muscle Aging [PDF]
Endocrinology and MetabolismCellular senescence is increasingly recognized as a pivotal mechanism driving skeletal muscle aging and the development of sarcopenia, a condition characterized by the progressive loss of muscle mass, strength, and function.
Yang Li, Huating Wang
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Inducible skeletal muscle-specific p53 deletion alleviates high-fat diet-induced insulin resistance by modulating mitochondria-associated membrane in obese mice [PDF]
Redox Biologyp53 has been implicated in metabolic regulation, but its role in obesity-induced skeletal muscle insulin resistance remains incompletely understood. This study aimed to determine the functional contribution of skeletal muscle p53 to insulin resistance ...
Soyoung Park +12 more
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Lithium as a Potential Senostatic Agent in Central Nervous System Aging and Bipolar Disorder [PDF]
PharmaceuticalsLithium remains the gold-standard maintenance treatment for bipolar disorder (BD) and is distinguished by its unique anti-suicidal and neuroprotective properties.
Janusz K. Rybakowski +3 more
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Bst2-targeted senotherapy restores visual function by eliminating senescent retinal cells [PDF]
Nature CommunicationsSenescent cells contribute to degenerative processes in multiple tissues, including the retina. In the retinal pigment epithelium (RPE), their accumulation is closely associated with retinal aging and disease progression.
Jun Yong Oh +15 more
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Inhibition of miMOMP-induced SASP to combat age-related disease [PDF]
Frontiers in AgingCellular senescence, first described in 1961, was initially observed in normal human fibroblasts that ceased proliferating after a finite number of divisions in culture.
Xiaoli Liao +4 more
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Antioxidant Senotherapy by Natural Compounds: A Beneficial Partner in Cancer Treatment
AntioxidantsAging is a general biological process inherent in all living organisms. It is characterized by progressive cellular dysfunction. For many years, aging has been widely recognized as a highly effective mechanism for suppressing the progression of malignant
Margarita Neganova, Yulia Aleksandrova
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Recycling senescent cell lipids for targeted senotherapy [PDF]
Nature CommunicationsSenescent cells (SnCs) are increasingly recognized as key contributors to osteoarthritis, with conventional strategies centered on their elimination.
Xiaoxiao Ji +18 more
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