Results 31 to 40 of about 276 (129)
Reshaping of the tumor microenvironment by cellular senescence: An opportunity for senotherapies
Developmental Cell, 2023 Cellular senescence is a stress response associated with aging and disease, including cancer. Senescent cells undergo a stable cell cycle arrest, undergo a change in morphology and metabolic reprogramming, and produce a bioactive secretome termed the senescence-associated secretory phenotype (SASP).
Gil, J, D’Ambrosio, M
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Senopathies—Diseases Associated with Cellular Senescence
Biomolecules, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak +2 more
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Ovarian aging: mechanisms and intervention strategies
Medical Review, 2022 Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced maternal age correlates with the progressive loss of both the quantity and quality of oocytes. The molecular mechanisms and various contributing factors underlying
Zhu Zhengmao, Xu Wanxue, Liu Lin
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Targeting Senescent Cells for a Healthier Aging: Challenges and Opportunities
Advanced Science, 2020 Aging is a physiological decline in both structural homeostasis and functional integrity, progressively affecting organismal health. A major hallmark of aging is the accumulation of senescent cells, which have entered a state of irreversible cell cycle ...
Shuling Song +4 more
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Biomolecules, 2023 Closely associated with aging and age-related disorders, cellular senescence (CS) is the inability of cells to proliferate due to accumulated unrepaired cellular damage and irreversible cell cycle arrest.
Prashanta Silwal +6 more
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Cellular Senescence and Senotherapies in the Kidney: Current Evidence and Future Directions [PDF]
Frontiers in Pharmacology, 2020 Cellular senescence refers to a cellular phenotype characterized by an altered transcriptome, pro-inflammatory secretome, and generally irreversible growth arrest. Acutely senescent cells are widely recognized as performing key physiological functions in vivo promoting normal organogenesis, successful wound repair, and cancer defense.
Marie Helena Docherty +7 more
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Senescence and Senolytics in Cardiovascular disease: Promise and Potential Pitfalls [PDF]
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular disease being the cause of death in 40% of individuals over 65 years old.
Spyridopoulos I +4 more
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Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies
Frontiers in Pharmacology, 2020 Age-related disorders such as chronic kidney disease (CKD) are increasingly prevalent globally and pose unprecedented challenges. In many aspects, CKD can be viewed as a state of accelerated and premature aging.
Jie Xu +3 more
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Cellular senescence in the aging retina and developments of senotherapies for age-related macular degeneration [PDF]
Journal of Neuroinflammation, 2021 AbstractAge-related macular degeneration (AMD), a degenerative disease in the central macula area of the neuroretina and the supporting retinal pigment epithelium, is the most common cause of vision loss in the elderly. Although advances have been made, treatment to prevent the progressive degeneration is lacking.
Keng Siang Lee +4 more
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Cellular Senescence in Skeletal Muscle Aging [PDF]
Endocrinology and MetabolismCellular senescence is increasingly recognized as a pivotal mechanism driving skeletal muscle aging and the development of sarcopenia, a condition characterized by the progressive loss of muscle mass, strength, and function.
Yang Li, Huating Wang
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