Results 31 to 40 of about 767 (193)
Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
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Targeting p21 for diabetes: Another choice of senotherapy
Cell Metabolism, 2022 Senotherapy, the elimination of senescent cells, is a cutting-edge treatment for aging-related and lifestyle diseases. In this issue of Cell Metabolism, Wang et al. report that p21Cip1 highly expressing cells, which represent a senescent cell population, occur in the adipose tissue during obesity.
Kondoh, Hiroshi, Hara, Eiji
openaire +2 more sources
Blunting senescence boosts liver regeneration [PDF]
, 2020 The mammalian liver possesses a unique capacity for regeneration. However, this regenerative potential declines with age due to unknown mechanisms. In this issue of Genes & Development, Ritschka and colleagues (pp. 489–494).
Birch, J, Gil, J
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The right time for senescence [PDF]
, 2021 Funding: We are truly grateful to Pedro Sousa-Vitor, Miguel Godinho-Ferreira, and Mariana AscençãoFerreira for critical reading of the manuscript. This work was supported by a FCT PhD Fellowship (PD/BD/105770/2014) to DPC, and co-funded by the FCT (PTDC ...
De-Carvalho, Diogo Paramos +2 more
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Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells
Cells, 2020 The progressive accumulation of apoptosis-resistant and secretory active senescent cells (SCs) in animal and human aged tissues may limit lifespan and healthspan and lead to age-related diseases such as cancer, neurodegenerative disorders, and metabolic ...
Jagoda Adamczyk-Grochala, Anna Lewinska
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Cellular senescence: a double-edged sword in cancer therapy
Frontiers in Oncology, 2023 Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stresses.
Shuai Xiao +11 more
doaj +1 more source
Dysregulated Cell Signaling in Pulmonary Emphysema [PDF]
, 2022 Pulmonary emphysema is characterized by the destruction of alveolar septa and irreversible airflow limitation. Cigarette smoking is the primary cause of this disease development.
Bahmed, Karim +3 more
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Galacto-conjugation of Navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity. [PDF]
, 2020 Pharmacologically active compounds with preferential cytotoxic activity for senescent cells, known as senolytics, can ameliorate or even revert pathological manifestations of senescence in numerous preclinical mouse disease models, including cancer ...
Bernardos, Andrea +19 more
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Ovarian aging: mechanisms and intervention strategies
Medical Review, 2022 Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced maternal age correlates with the progressive loss of both the quantity and quality of oocytes. The molecular mechanisms and various contributing factors underlying
Zhu Zhengmao, Xu Wanxue, Liu Lin
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Senopathies—Diseases Associated with Cellular Senescence
Biomolecules, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak +2 more
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