Results 31 to 40 of about 646 (170)
Hallmarks and Biomarkers of Skin Senescence: An Updated Review of Skin Senotherapeutics
Antioxidants, 2023 Aging is a complex process characterized by an ongoing decline in physiological functions, leading to degenerative diseases and an increased probability of death. Cellular senescence has been typically considered as an anti-proliferative process; however,
Darya Bulbiankova +5 more
doaj +1 more source
Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies [PDF]
Cancers, 2020 Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour suppressive process, both by preventing cancer cell proliferation and suppressing malignant progression from pre ...
Wyld, L. +8 more
openaire +4 more sources
Assessment of Pullulan, a Microbial Polysaccharide, as a Matrix for Senotherapeutics Delivery
Chemistry Proceedings, 2023 This study’s objective was to assess pullulan, in the form of pullulan acetate, as a matrix for senotherapeutics delivery. Polymeric nanoparticles loaded with various senotherapeutics (metformin, quercitin, kaempferol, curcumin, and luteolin) were ...
Ramona-Daniela Pavaloiu +4 more
doaj +1 more source
Senotherapeutics in Cancer and HIV
Cells, 2022 Cellular senescence is a stress-response mechanism that contributes to homeostasis maintenance, playing a beneficial role during embryogenesis and in normal adult organisms.
Laura Sánchez-Díaz +3 more
doaj +1 more source
Nano-Based Theranostic Tools for the Detection and Elimination of Senescent Cells
Cells, 2020 The progressive accumulation of apoptosis-resistant and secretory active senescent cells (SCs) in animal and human aged tissues may limit lifespan and healthspan and lead to age-related diseases such as cancer, neurodegenerative disorders, and metabolic ...
Jagoda Adamczyk-Grochala, Anna Lewinska
doaj +1 more source
Cellular senescence: a double-edged sword in cancer therapy
Frontiers in Oncology, 2023 Over the past few decades, cellular senescence has been identified in cancer patients undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by permanent cell cycle arrest as a response to endogenous and exogenous stresses.
Shuai Xiao +11 more
doaj +1 more source
Senescence and senotherapies in biliary atresia and biliary cirrhosis
Aging, 2023 Premature senescence occurs in adult hepatobiliary diseases and worsens the prognosis through deleterious liver remodeling and hepatic dysfunction. Senescence might also arises in biliary atresia (BA), the first cause of pediatric liver transplantation. Since alternatives to transplantation are needed, our aim was to investigate premature senescence in
Jannone, Giulia +12 more
openaire +3 more sources
Targeting Cellular Senescence with Liposome-Encapsulated Fisetin: Evidence of Senomorphic Effect. [PDF]
Int J Mol SciCellular senescence is closely connected with cancer progression, recurrence, and metastasis. Senotherapy aims to soothe the harmful effects of senescent cells either by inducing their apoptosis (senolytic) or by suppressing the senescence-associated ...
Henschke A +5 more
europepmc +2 more sources
Senopathies—Diseases Associated with Cellular Senescence
Biomolecules, 2023 Cellular senescence describes a stable cell cycle arrest state with a characteristic phenotype. Senescent cells accumulate in the human body during normal aging, limiting the lifespan and promoting aging-related, but also several non-related, pathologies.
Oleh Lushchak +2 more
doaj +1 more source
Ovarian aging: mechanisms and intervention strategies
Medical Review, 2022 Ovarian reserve is essential for fertility and influences healthy aging in women. Advanced maternal age correlates with the progressive loss of both the quantity and quality of oocytes. The molecular mechanisms and various contributing factors underlying
Zhu Zhengmao, Xu Wanxue, Liu Lin
doaj +1 more source