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Фармакокинетика и ФармакодинамикаSenescence — cellular aging — is a special form of cell death, characterized by the cell’s irreversible loss of its proliferation potential and the development of resistance to apoptosis.
S. A. Kryzhanovskii, M. B. Vititnova
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BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J Rademacher, Eileen M Foecking
exaly +6 more sources
Impact and potential value of immunosenescence on solid gastrointestinal tumors [PDF]
Frontiers in ImmunologySolid gastrointestinal tumors often respond poorly to immunotherapy for the complex tumor microenvironment (TME), which is exacerbated by immune system alterations. Immunosenescence is the process of increased diversification of immune genes due to aging
Tianshuai Zhang +8 more
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Targeting p21 for diabetes: Another choice of senotherapy [PDF]
Cell Metabolism, 2022 Senotherapy, the elimination of senescent cells, is a cutting-edge treatment for aging-related and lifestyle diseases. In this issue of Cell Metabolism, Wang et al. report that p21Cip1 highly expressing cells, which represent a senescent cell population, occur in the adipose tissue during obesity.
Kondoh, Hiroshi, Hara, Eiji
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A stress-induced cilium-to-PML-NB route drives senescence initiation
Nature Communications, 2023 Exposure to irreparable stresses induces transient ciliogenesis, enabling communication with PML-NBs via a FBF1 pathway to trigger senescence in mammalian cells.
Xiaoyu Ma +14 more
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The potential for senotherapy as a novel approach to extend life quality in veterinary medicine
Frontiers in Veterinary ScienceCellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans.
, Steven Dow, Lyndah Chow
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The use of betaine as a novel senotherapy [PDF]
Background: The global population demographic comprising those aged 65 years and over is increasing. Despite an increase in human life expectancy over the past 150 years, this has not been matched by a similar increase in health span (i.e. years of disease free living).
Tran, Ngoc Uyen
core +4 more sources
An evaluation of the role of miR-361-5p in senescence and systemic ageing [PDF]
Experimental Gerontology, 2023 Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular senescence, with several known to regulate important genes associated with this process.We sought ...
Emad Manni +5 more
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A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy. [PDF]
Int J Mol SciTo identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs). Alterations in transcriptome profiles upon aging between humans and mice were then compared.
Poisa-Beiro L +12 more
europepmc +4 more sources
Cellular Senescence: Mechanisms and Therapeutic Potential
Biomedicines, 2021 Cellular senescence is a complex and multistep biological process which cells can undergo in response to different stresses. Referring to a highly stable cell cycle arrest, cellular senescence can influence a multitude of biological processes—both ...
Zehuan Liao +3 more
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