Results 11 to 20 of about 767 (193)
A biomimetic senotherapy replenishing MAT2A promotes wound regeneration in preclinical models [PDF]
Nature CommunicationsTimely infiltration and effective turnover of macrophages after trauma are essential for wound regeneration. In pathological conditions, such as diabetic wounds, how disturbances in cellular collaboration leads to persistent inflammatory infiltration ...
Dongming LV +15 more
doaj +3 more sources
BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher +2 more
exaly +4 more sources
The potential for senotherapy as a novel approach to extend life quality in veterinary medicine
Frontiers in Veterinary ScienceCellular senescence, a condition where cells undergo arrest and can assume an inflammatory phenotype, has been associated with initiation and perpetuation of inflammation driving multiple disease processes in rodent models and humans.
Lynn M Pezzanite
exaly +5 more sources
The use of betaine as a novel senotherapy [PDF]
Background: The global population demographic comprising those aged 65 years and over is increasing. Despite an increase in human life expectancy over the past 150 years, this has not been matched by a similar increase in health span (i.e.
Tran, Ngoc Uyen
core +5 more sources
A novel senotherapeutic strategy with azithromycin for preventing endometriosis progression [PDF]
Reproductive Biology and EndocrinologyBackground Endometriosis is an estrogen-dependent chronic inflammatory disease, however the mechanisms underlying inflammation remain unclear. Non-hormonal drugs that can prevent endometriosis progression and resolve endometriotic infertility are ...
Reina Sonehara +11 more
doaj +2 more sources
Translational Medicine of Aging, 2023 Chronic aging represents the leading risk factor for the vast majority of age-related diseases, which together contribute to increased morbidities and elevated mortalities in late life.
Yu Sun
doaj +2 more sources
Advances in Nanotherapy for Targeting Senescent Cells. [PDF]
Int J NanomedicineYurou Shi,1,2,* Yingjie Zhang,1,* Yaxuan Zhang,2 Jiali Yao,2 Junping Guo,3 Xiaoling Xu,2 Lijun Wang1 1Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital), Hangzhou Medical ...
Shi Y +6 more
europepmc +3 more sources
Integrative Approaches to Treating Cellular Senescence in Kidney Disease
Advanced ScienceCellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in ...
Tomoka Misawa +3 more
doaj +2 more sources
SUN-648 Monogenic Syndromic Obesity of Alström Syndrome as a Model of Premature Aging [PDF]
J Endocr SocDisclosure: S. Ali: None. P. Thomas: None. N. Duggal: None. G. da Silva: None. T. Geberhiwot: None. In recent years, cellular senescence has emerged as a key contributor to the pathogenesis of metabolic syndrome (MetS) and its associated complications ...
Ali, Sadaf +4 more
europepmc +3 more sources