Results 11 to 20 of about 276 (129)
Senesens. Heart. Senotherapy [PDF]
Фармакокинетика и ФармакодинамикаSenescence — cellular aging — is a special form of cell death, characterized by the cell’s irreversible loss of its proliferation potential and the development of resistance to apoptosis.
S. A. Kryzhanovskii, M. B. Vititnova
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Senotherapy: scientific advances and clinical potential of senolytic therapies
O Mundo da SaúdeSenotherapy represents an emerging therapeutic approach to combat deleterious senescent cells, whose pro-inflammatory accumulation contributes to various aging-associated pathologies. This study aimed to analyze and systematize recent scientific advances
Adriele Afonso Miranda +5 more
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An evaluation of the role of miR-361-5p in senescence and systemic ageing [PDF]
Experimental Gerontology, 2023 Senescent cells are key regulators of ageing and age-associated disease. MicroRNAs (miRs) are a key component of the molecular machinery governing cellular senescence, with several known to regulate important genes associated with this process.We sought ...
Emad Manni +5 more
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Targeting p21 for diabetes: Another choice of senotherapy [PDF]
Cell Metabolism, 2022 Senotherapy, the elimination of senescent cells, is a cutting-edge treatment for aging-related and lifestyle diseases. In this issue of Cell Metabolism, Wang et al. report that p21Cip1 highly expressing cells, which represent a senescent cell population, occur in the adipose tissue during obesity.
Kondoh, Hiroshi, Hara, Eiji
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BiomedicinesParkinson’s disease (PD) is an aging-related neurodegenerative disease characterized by a progressive loss of dopamine (DA)-secreting neurons in the substantia nigra. Most of the currently available treatments attempt to alleviate the disease symptoms by
David J. Rademacher +2 more
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The use of betaine as a novel senotherapy [PDF]
Background: The global population demographic comprising those aged 65 years and over is increasing. Despite an increase in human life expectancy over the past 150 years, this has not been matched by a similar increase in health span (i.e. years of disease free living).
Tran, Ngoc Uyen
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Aging Cell, Volume 25, Issue 9, September 2026.The aging of the human body is a complex process driven by multiple contributing factors. Based on their underlying mechanisms, current anti‐aging interventions can be classified into six primary categories. This paper summarizes the most promising anti‐aging strategies within each class. ABSTRACT The global prevalence of aging and age‐related diseases
Feifei Li +4 more
wiley +2 more sources
Advanced ScienceThe greatest challenge in atherosclerosis (AS) management lies in achieving lesion reversal, not merely slowing progression. Senescent cell accumulation—driven by continuous generation and apoptotic resistance—perpetuates plaque pathology and obstructs ...
Yuhan Tian +9 more
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Natural killer cell-based senotherapy: a promising strategy for healthy aging
Frontiers in ImmunologyOne of the most significant risk factors for diseases is aging. Interestingly, some organisms, such as naked mole-rats and most turtles, do not exhibit typical aging-like symptoms or increased mortality as they become older.
Tsutomu Nakazawa +4 more
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A Senescent Cluster in Aged Human Hematopoietic Stem Cell Compartment as Target for Senotherapy
International Journal of Molecular SciencesTo identify the differences between aged and young human hematopoiesis, we performed a direct comparison of aged and young human hematopoietic stem and progenitor cells (HSPCs). Alterations in transcriptome profiles upon aging between humans and mice were then compared.
Poisa-Beiro, Laura +12 more
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