Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis
Cell Reports, 2023 Summary: Senescent cells can spread the senescent phenotype to other cells by secreting senescence-associated secretory phenotype factors. The resulting paracrine senescent cells make a significant contribution to the burden of senescent cell ...
Tesfahun Dessale Admasu +9 more
doaj +2 more sources
Cytotoxic CD4+ T cells eliminate senescent cells by targeting cytomegalovirus antigen
Cell, 2023 Senescent cell accumulation has been implicated in the pathogenesis of aging-associated diseases including cancer. The mechanism that prevents the accumulation of senescent cells in aging human organs is unclear.
Tatsuya Hasegawa +2 more
exaly +2 more sources
The states of senescent cells. [PDF]
Biochem Soc TransSenescent cells (SnCs) have typical changes in multiple features, such as increased cellular and nuclear size, morphofunctional alterations in organelles, and high secretory activity. The literature generally groups cellular changes and the non-proliferative character of SnCs into the autonomous senescent phenotype.
de Mendonça LB +2 more
europepmc +4 more sources
The role of senescent cells in ageing [PDF]
Nature, 2014 Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair ...
Jan M. van Deursen
semanticscholar +3 more sources
Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies [PDF]
Nature CommunicationsAccumulation of senescent cells is associated with aging and age-related diseases. However, current clearance therapies targeting senescent cells are often limited by low efficiency, poor specificity, and insufficient penetration.
Chengkang Jin +10 more
doaj +2 more sources
The lysosomal proteome of senescent cells contributes to the senescence secretome
Aging Cell, 2022 Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age‐related diseases. Senescent cells present a remarkable increase in lysosomal mass and elevated autophagic activity.
Miguel Rovira +11 more
semanticscholar +6 more sources
Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer
Advanced Science, 2021 Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of senescent tumor cells in colorectal cancer (CRC).
Yong Won Choi +13 more
doaj +2 more sources
p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer
Heliyon, 2023 Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer progression by secreting senescence-related molecules, called senescence-associated secreting phenotypes.
Soon Sang Park +8 more
doaj +3 more sources
Targeting immunosenesence promotes clearance of senescent cells [PDF]
Immunity & AgeingKnown as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age ...
Anteneh Mehari Tizazu +2 more
doaj +2 more sources
Spatial Distribution of Senescent Cells and Their Proximity to Immune Subsets in the Human Endometrium During the Implantation Window [PDF]
DiagnosticsBackground/Objectives: Senescent cells contribute to endometrial remodeling during the implantation window, but their spatial organization within the stroma remains poorly understood.
Dimitar Parvanov +9 more
doaj +2 more sources