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Escape and evasion: when immunosurveillance of senescent cells goes wrong [PDF]

Frontiers in Genetics
Aging involves molecular changes that can give rise to different cell fates, one of those being cellular senescence. Senescent cells stably arrest in the cell cycle and play important roles in physiological processes and can act in a tumor-suppressive ...
Elina Shakur, Elina Shakur, Elina Shakur, Abraham Jacobs, Abraham Jacobs, Abraham Jacobs, Rituparna Ghosh, Rituparna Ghosh, Rituparna Ghosh, Matthew J. Yousefzadeh, Matthew J. Yousefzadeh, Matthew J. Yousefzadeh   +11 more
doaj   +2 more sources

The states of senescent cells. [PDF]

Biochem Soc Trans
Senescent cells (SnCs) have typical changes in multiple features, such as increased cellular and nuclear size, morphofunctional alterations in organelles, and high secretory activity. The literature generally groups cellular changes and the non-proliferative character of SnCs into the autonomous senescent phenotype.
de Mendonça LB, Lenz G, Filippi-Chiela EC.   +2 more
europepmc   +4 more sources

Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer

Advanced Science, 2021
Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of senescent tumor cells in colorectal cancer (CRC).
Yong Won Choi, Young Hwa Kim, Seung Yeop Oh, Kwang Wook Suh, Young‐Sam Kim, Ga‐Yeon Lee, Jung Eun Yoon, Soon Sang Park, Young‐Kyoung Lee, Yoo Jung Park, Hong Seok Kim, So Hyun Park, Jang‐Hee Kim, Tae Jun Park   +13 more
doaj   +2 more sources

The Immunogenicity of Human Senescent Cells Is Dependent on the Senescence Inducer and Cell Type. [PDF]

Aging Cell
ABSTRACT Senescent cells accumulate with age and after exposure to various stresses, contributing to chronic diseases and cancer, effects largely driven by the senescence‐associated secretory phenotype (SASP). Recent evidence indicates that a subset of senescent cells exhibits immunogenic properties.
Goyer ML, Sonn A, Benabdallah B, Le O, Dulong J, Oschwald J, Sirois I, Apavaloaei A, Hesnard L, Guimond JV, Haddad E, Beauséjour C.   +11 more
europepmc   +3 more sources

Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies [PDF]

Nature Communications
Accumulation of senescent cells is associated with aging and age-related diseases. However, current clearance therapies targeting senescent cells are often limited by low efficiency, poor specificity, and insufficient penetration.
Chengkang Jin, Xiaoling Xu, Ning Yao, Hairui Zhang, Changjiang Chen, Lingyao Zeng, Zhiyun Liu, Lanjie Lei, Shumao Cui, Chengping Wen, Liyun Shi   +10 more
doaj   +2 more sources

p15INK4B is an alternative marker of senescent tumor cells in colorectal cancer

Heliyon, 2023
Senescent tumor cells are nonproliferating tumor cells which are closely related to cancer progression by secreting senescence-related molecules, called senescence-associated secreting phenotypes.
Soon Sang Park, Young-Kyoung Lee, So Hyun Park, Su Bin Lim, Yong Won Choi, Jun Sang Shin, Young Hwa Kim, Jang-Hee Kim, Tae Jun Park   +8 more
doaj   +3 more sources

Targeting immunosenesence promotes clearance of senescent cells [PDF]

Immunity & Ageing
Known as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age ...
Anteneh Mehari Tizazu, Eyerusalem Amossa Tessema, Olivier NF. Cexus   +2 more
doaj   +2 more sources

Spatial Distribution of Senescent Cells and Their Proximity to Immune Subsets in the Human Endometrium During the Implantation Window [PDF]

Diagnostics
Background/Objectives: Senescent cells contribute to endometrial remodeling during the implantation window, but their spatial organization within the stroma remains poorly understood.
Dimitar Parvanov, Rumiana Ganeva, Margarita Ruseva, Maria Handzhiyska, Jinahn Safir, Lachezar Jelezarsky, Nina Vidolova, Dimitar Metodiev, Georgi Stamenov, Savina Hadjidekova   +9 more
doaj   +2 more sources

Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis

Cell Reports, 2023
Summary: Senescent cells can spread the senescent phenotype to other cells by secreting senescence-associated secretory phenotype factors. The resulting paracrine senescent cells make a significant contribution to the burden of senescent cell ...
Tesfahun Dessale Admasu, Kristie Kim, Michael Rae, Roberto Avelar, Ryan L. Gonciarz, Abdelhadi Rebbaa, João Pedro de Magalhães, Adam R. Renslo, Alexandra Stolzing, Amit Sharma   +9 more
doaj   +1 more source

A senescent cell bystander effect: senescence‐induced senescence [PDF]

Aging Cell, 2012
SummarySenescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented.
Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T   +6 more
openaire   +3 more sources