Results 1 to 10 of about 112,157 (308)

Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies [PDF]

Nature Communications
Accumulation of senescent cells is associated with aging and age-related diseases. However, current clearance therapies targeting senescent cells are often limited by low efficiency, poor specificity, and insufficient penetration.
Chengkang Jin, Xiaoling Xu, Ning Yao, Hairui Zhang, Changjiang Chen, Lingyao Zeng, Zhiyun Liu, Lanjie Lei, Shumao Cui, Chengping Wen, Liyun Shi   +10 more
doaj   +2 more sources

Targeting immunosenesence promotes clearance of senescent cells [PDF]

Immunity & Ageing
Known as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age ...
Anteneh Mehari Tizazu, Eyerusalem Amossa Tessema, Olivier NF. Cexus   +2 more
doaj   +2 more sources

Spatial Distribution of Senescent Cells and Their Proximity to Immune Subsets in the Human Endometrium During the Implantation Window [PDF]

Diagnostics
Background/Objectives: Senescent cells contribute to endometrial remodeling during the implantation window, but their spatial organization within the stroma remains poorly understood.
Dimitar Parvanov, Rumiana Ganeva, Margarita Ruseva, Maria Handzhiyska, Jinahn Safir, Lachezar Jelezarsky, Nina Vidolova, Dimitar Metodiev, Georgi Stamenov, Savina Hadjidekova   +9 more
doaj   +2 more sources

Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis

Cell Reports, 2023
Summary: Senescent cells can spread the senescent phenotype to other cells by secreting senescence-associated secretory phenotype factors. The resulting paracrine senescent cells make a significant contribution to the burden of senescent cell ...
Tesfahun Dessale Admasu, Kristie Kim, Michael Rae, Roberto Avelar, Ryan L. Gonciarz, Abdelhadi Rebbaa, João Pedro de Magalhães, Adam R. Renslo, Alexandra Stolzing, Amit Sharma   +9 more
doaj   +1 more source

A senescent cell bystander effect: senescence‐induced senescence [PDF]

Aging Cell, 2012
SummarySenescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented.
Nelson G, Wordsworth J, Wang CF, Jurk D, Lawless C, Martin-Ruiz C, von Zglinicki T   +6 more
openaire   +3 more sources

Targeting cellular senescence in metabolic disease

Molecular Metabolism, 2022
Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis, and the development of a secretome that can be pro-inflammatory.
Allyson K. Palmer, Tamar Tchkonia, James L. Kirkland   +2 more
doaj   +1 more source

Senescent Cell Depletion Through Targeting BCL-Family Proteins and Mitochondria

Frontiers in Physiology, 2020
Senescent cells with replicative arrest can be generated during genotoxic, oxidative, and oncogenic stress. Long-term retention of senescent cells in the body, which is attributed to highly expressed BCL-family proteins, chronically damages tissues ...
Ying Fan, Ying Fan, Ying Fan, Jiaoqi Cheng, Jiaoqi Cheng, Huihong Zeng, Huihong Zeng, Lijian Shao, Lijian Shao, Lijian Shao   +9 more
doaj   +1 more source

RANKL+ senescent cells under mechanical stress: a therapeutic target for orthodontic root resorption using senolytics

International Journal of Oral Science, 2023
In dentistry, orthodontic root resorption is a long-lasting issue with no effective treatment strategy, and its mechanisms, especially those related to senescent cells, remain largely unknown.
Yue Zhou, Aki Nishiura, Hidetoshi Morikuni, Wenqi Deng, Toru Tsujibayashi, Yoshihiro Momota, Yuki Azetsu, Masamichi Takami, Yoshitomo Honda, Naoyuki Matsumoto   +9 more
doaj   +1 more source

Executing Cell Senescence [PDF]

Cell Cycle, 2004
Senescence is a permanent form of cell cycle arrest that limits the proliferation of damaged cells and may contribute to tumor suppression and aging. We recently demonstrated that some senescent cell types undergo dramatic changes in chromatin organization that are dependent on the retinoblastoma protein and are associated with the stable repression of
Masashi, Narita, Scott W, Lowe
openaire   +2 more sources

Immune Clearance of Senescent Cells to Combat Ageing and Chronic Diseases

Cells, 2020
Senescent cells are generally characterized by permanent cell cycle arrest, metabolic alteration and activation, and apoptotic resistance in multiple organs due to various stressors.
Ping Song, Junqing An, Ming-Hui Zou
doaj   +1 more source