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Escape and evasion: when immunosurveillance of senescent cells goes wrong [PDF]
Frontiers in GeneticsAging involves molecular changes that can give rise to different cell fates, one of those being cellular senescence. Senescent cells stably arrest in the cell cycle and play important roles in physiological processes and can act in a tumor-suppressive ...
Elina Shakur +11 more
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Selective ablation of primary and paracrine senescent cells by targeting iron dyshomeostasis
Cell Reports, 2023 Summary: Senescent cells can spread the senescent phenotype to other cells by secreting senescence-associated secretory phenotype factors. The resulting paracrine senescent cells make a significant contribution to the burden of senescent cell ...
Tesfahun Dessale Admasu +9 more
doaj +4 more sources
Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer
Advanced Science, 2021 Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of senescent tumor cells in colorectal cancer (CRC).
Yong Won Choi +13 more
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Prodrug nanoplatform for triggering ferroptosis to eliminate senescent cells in age-associated pathologies [PDF]
Nature CommunicationsAccumulation of senescent cells is associated with aging and age-related diseases. However, current clearance therapies targeting senescent cells are often limited by low efficiency, poor specificity, and insufficient penetration.
Chengkang Jin +10 more
doaj +2 more sources
A versatile drug delivery system targeting senescent cells [PDF]
EMBO Molecular Medicine, 2018 Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a ...
Daniel Muñoz‐Espín +18 more
doaj +3 more sources
Advanced ScienceSenescent cancer cells are endowed with high immunogenic potential that has been leveraged to elicit antitumor immunity and potentially complement anticancer therapies.
Chao Yang +11 more
doaj +2 more sources
Targeting immunosenesence promotes clearance of senescent cells [PDF]
Immunity & AgeingKnown as immunosenescence, the major dysregulation of the immune system with age is associated with poor vaccination efficacy, and increased susceptibility to infections, age-related pathologies, and neoplasms, with incidences exacerbated with age ...
Anteneh Mehari Tizazu +2 more
doaj +2 more sources
Senescent human diploid fibroblasts are able to support DNA synthesis and to express markers associated with proliferation [PDF]
, 1990 The characteristic limited reproductive life-span of normal human fibroblasts in culture is due to a steadily decreasing fraction of cells able to proliferate in the standard rich growth media.
Shall, S, Kill, IR
core +7 more sources
The states of senescent cells. [PDF]
Biochem Soc TransSenescent cells (SnCs) have typical changes in multiple features, such as increased cellular and nuclear size, morphofunctional alterations in organelles, and high secretory activity. The literature generally groups cellular changes and the non-proliferative character of SnCs into the autonomous senescent phenotype.
de Mendonça LB +2 more
europepmc +4 more sources
A senescent cell bystander effect: senescence‐induced senescence [PDF]
Aging Cell, 2012 SummarySenescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented.
Nelson G +6 more
openaire +3 more sources