GRSF1 suppresses cell senescence
Aging, 2018 A prominent phenotype triggered by the loss of mitochondrial homeostasis is cellular senescence, characterized by cessation of growth and a senescence-associated secretory phenotype (SASP). We identified the G-rich RNA sequence-binding factor 1 (GRSF1) as a major mitochondrial protein implicated in this response.
Noh, Ji Heon +6 more
openaire +2 more sources
Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF)
Cell Death Discovery, 2023 Cellular senescence is involved in the development of pulmonary fibrosis as well as in lung tissue repair and regeneration. Therefore, a strategy of removal of senescent cells by senolytic drugs may not produce the desired therapeutic result.
Amitava Mukherjee +11 more
doaj +1 more source
Targeting senescent cell clearance: An approach to delay aging and age-associated disorders
Translational Medicine of Aging, 2021 Cellular senescence is the occurrence of irreversible cell cycle arrest resulting from accumulated DNA damage and the loss of proteostasis over time. Senescent cells contribute to age-related diseases and aging itself. Therefore, the targeted elimination
Zhengqi Qiu +5 more
doaj +1 more source
Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence [PDF]
, 2019 The activation of cellular senescence throughout the lifespan promotes tumor suppression, whereas the persistence of senescent cells contributes to aspects of aging.
Diekman, Brian O. +9 more
core +3 more sources
Ring-like distribution of constitutive heterochromatin in bovine senescent cells. [PDF]
PLoS ONE, 2011 BACKGROUND: Cells that reach "Hayflick limit" of proliferation, known as senescent cells, possess a particular type of nuclear architecture. Human senescent cells are characterized by the presence of highly condensed senescent associated heterochromatin ...
Andrey Pichugin +3 more
doaj +1 more source
Chemotherapy accelerates immune-senescence and functional impairments of Vδ2pos T cells in elderly patients affected by liver metastatic colorectal cancer. [PDF]
, 2019 Human (gamma delta) γδ T cells are unconventional innate-like lymphocytes displaying a broad array of anti-tumor activities with promising perspectives in cancer immunotherapy.
Bruni E +9 more
core +1 more source
Accelerated aging in perinatally HIV-infected children: clinical manifestations and pathogenetic mechanisms [PDF]
, 2018 BACKGROUND: Premature aging and related diseases have been documented in HIV-infected adults. Data are now emerging also regarding accelerated aging process in HIV-infected children. METHODS: A narrative review was performed searching studies on PubMed
Bianconi, Martina +6 more
core +1 more source
Cell fusion induced senescence
Aging, 2014 Cellular senescence has long been established as a stable and irreversible growth arrest, which plays an important role in tumor suppression and tissue repair. It can be induced by various stimuli, including telomere shortening, oncogene activation and oxidative stress. We recently demonstrated that cell-cell fusion is a previously unidentified trigger
Hilah, Gal, Valery, Krizhanovsky
openaire +2 more sources
A versatile drug delivery system targeting senescent cells
EMBO Molecular Medicine, 2018 Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a ...
Daniel Muñoz‐Espín +18 more
doaj +1 more source
Senescent Tumor Cells Build a Cytokine Shield in Colorectal Cancer
Advanced Science, 2021 Cellular senescence can either support or inhibit cancer progression. Here, it is shown that intratumoral infiltration of CD8+ T cells is negatively associated with the proportion of senescent tumor cells in colorectal cancer (CRC).
Yong Won Choi +13 more
doaj +1 more source