Targeting senescent cells enhances adipogenesis and metabolic function in old age
eLife, 2015 Senescent cells accumulate in fat with aging. We previously found genetic clearance of senescent cells from progeroid INK-ATTAC mice prevents lipodystrophy.
Ming Xu +13 more
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Single-cell transcriptomics identifies Mcl-1 as a target for senolytic therapy in cancer
Nature Communications, 2022 Cells subjected to treatment with anti-cancer therapies can evade apoptosis through cellular senescence. Persistent senescent tumor cells remain metabolically active, possess a secretory phenotype, and can promote tumor proliferation and metastatic ...
Martina Troiani +14 more
doaj +1 more source
From the divergence of senescent cell fates to mechanisms and selectivity of senolytic drugs
Open Biology, 2022 Senescence is a cellular stress response that involves prolonged cell survival, a quasi-irreversible proliferative arrest and a modification of the transcriptome that sometimes includes inflammatory gene expression.
Valentin L'Hôte +2 more
doaj +1 more source
Scientific Reports, 2022 Characteristics of cell migration in a confluent population depend on the nature of cell-to-cell interactions as well as cell-intrinsic properties such as the directional persistence in crawling.
Thamara Liz Gabuardi +2 more
doaj +1 more source
Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death
, 2023 Pre-clinical studies from the recent past have indicated that senescent cells can negatively affect health and contribute to premature aging. Targeted eradication of these cells has been shown to improve the health of aged experimental animals, leading ...
Shafaat Y. Khan +11 more
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Senescent Cells Impair Erectile Function through Induction of Endothelial Dysfunction and Nerve Injury in Mice. [PDF]
PLoS ONE, 2015 Erectile dysfunction (ED) is a major health problem, particularly in the elderly population, which is rapidly increasing. It is necessary to elucidate the mechanism by which ED occurs in the elderly.
Hiroaki Nishimatsu +7 more
doaj +1 more source
Genetic screens identify novel liabilities of senescent cells [PDF]
, 2021 Drugs that selectively kill senescent cells, senolytics, can improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited.
McHugh, Domhnall Seamus
core +1 more source
COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells
Nature Cell Biology, 2023 Drugs that selectively kill senescent cells (senolytics) improve the outcomes of cancer, fibrosis and age-related diseases. Despite their potential, our knowledge of the molecular pathways that affect the survival of senescent cells is limited.
Domhnall McHugh +19 more
semanticscholar +1 more source
Cell senescence, the senescence-associated secretory phenotype, and cancers
PLOS Biology, 2023 Cellular senescence is a cell fate caused by multiple stresses. A 2008 article in PLOS Biology reported a senescence-associated secretory phenotype that can promote inflammation and cancer, eventually enabling the development of senolytic drugs.
Larissa G. P. Langhi Prata +2 more
openaire +3 more sources
Aging in vitro and D-glucose uptake kinetics of diploid human fibroblasts [PDF]
, 1981 By use of a rapid technique, initial rates of D-glucose transport were obtained during the lifespan in vitro of a commercially available strain of human embryo lung fibroblasts (Flow 2000).
Cremer, Thomas +4 more
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