Results 41 to 50 of about 4,484,629 (285)

Inhibition of tyrosine kinase Fgr prevents radiation-induced pulmonary fibrosis (RIPF)

Cell Death Discovery, 2023
Cellular senescence is involved in the development of pulmonary fibrosis as well as in lung tissue repair and regeneration. Therefore, a strategy of removal of senescent cells by senolytic drugs may not produce the desired therapeutic result.
Amitava Mukherjee, Michael W. Epperly, Renee Fisher, Wen Hou, Donna Shields, M. Saiful Huq, Phillip M. Pifer, Ria Mulherkar, Tyler J. Wilhite, Hong Wang, Peter Wipf, Joel S. Greenberger   +11 more
doaj   +1 more source

A versatile drug delivery system targeting senescent cells

EMBO Molecular Medicine, 2018
Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a ...
Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano   +18 more
doaj   +1 more source

The senescent cell epigenome

Aging, 2018
A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory cytokine release in cells, caused by a variety of stresses. Recent work has convincingly linked the accumulation of senescent cells in aged tissues to a decline in health and a limit of lifespan, primarily through "inflammaging".
Yang, Na, Sen, Payel
openaire   +2 more sources

Lipophilic Statins Eliminate Senescent Endothelial Cells by inducing Anoikis-Related Cell Death

, 2023
Pre-clinical studies from the recent past have indicated that senescent cells can negatively affect health and contribute to premature aging. Targeted eradication of these cells has been shown to improve the health of aged experimental animals, leading ...
Shafaat Y. Khan, Markus Lipovac, Johannes M. Breuss, Ezzat M. Awad, Ulrike Resch, Simon Hess, Pavel Uhrin, Nicholas K. Wedige, Marlene Fellner, Barbora Belakova, André Oszwald, Karel Šmejkal   +11 more
core   +1 more source

Vascular Cell Senescence [PDF]

Circulation Research, 2007
Cardiologists and most physicians believe that aging is an independent risk factor for human atherosclerosis, whereas atherosclerosis is thought to be a characteristic feature of aging in humans by many gerontologists. Because atherosclerosis is among the age-associated changes that almost always escape the influence of natural selection in humans, it ...
Tohru, Minamino, Issei, Komuro
openaire   +2 more sources

Aging in vitro and D-glucose uptake kinetics of diploid human fibroblasts [PDF]

, 1981
By use of a rapid technique, initial rates of D-glucose transport were obtained during the lifespan in vitro of a commercially available strain of human embryo lung fibroblasts (Flow 2000).
Cremer, Thomas, Stevenson, A. F. G., Werdan, K., Lehner, K., Messerschmidt, O.   +4 more
core   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

Oral Senescence: From Molecular Biology to Clinical Research

Frontiers in Dental Medicine, 2022
Cellular senescence is an irreversible cell cycle arrest occurring following multiple rounds of cell division (replicative senescence) or in response to cellular stresses such as ionizing radiation, signaling imbalances and oxidative damage (stress ...
Eric Kenneth Parkinson, Stephen Stewart Prime   +1 more
doaj   +1 more source

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Biomaterials targeting senescent cells for bone regeneration: State-of-the-art and future perspectives. [PDF]

Bioact Mater
Bone defect treatment remains a significant clinical challenge, further exacerbated by the demographic transition toward an aging society. In elderly populations, the increased proportion of senescent cells emerges as a fundamental determinant that ...
Wu H, Zhang Q, Zhu J, Wu L, Xiao Y, Yang X.   +5 more
europepmc   +2 more sources